Exopolysaccharide from Trichoderma pseudokoningii promotes maturation of murine dendritic cells

Isolation of Polysaccharides from Trichoderma harzianum with Antioxidant, Anticancer, and Enzyme Inhibition Properties

“…The materials used in the present study are summarized and shown in the Supplementary Materials . The IPSs and EPSs were isolated from T. harzianum according to the methods described previously, with minor modifications [ 25 , 29 ]. For the preparation of seed culture, T. harzianum was inoculated in potato dextrose agar and incubated at 28 ± 2 °C for 4 days.…”

“…This fungus is also known to produce various molecules, including enzymes and secondary metabolites with promising anticancer, antitumor, antioxidant, antibacterial, and antiviral activities [ 19 , 20 , 21 , 22 , 23 , 24 ]. However, only a few works have reported on the polysaccharides from Trichoderma species with anticancer, microphage activation, and antioxidant activities [ 3 , 25 , 26 , 27 , 28 , 29 ]. In addition, the burgeoning of novel chronic disorders, including cancer and oxidative-stress-related diseases, prompts the search for novel health-beneficial compounds from plants, fungi, and bacteria.…”

Fucose-containing bacterial exopolysaccharides: Sources, biological activities, and food applications

“…According to previous studies, FcEPS of T. pseudokoningii demonstrated not only anti-tumor activity but also immunomodulatory activity, which was attributed to the activation of toll-like receptor-4 and dectin-1 specific antibodies by FcEPS through the NF-κB and MAPK signaling pathways, thereby inhibiting the secretion of cytokines ( Wang et al, 2016 ). Moreover, FcEPS of T. pseudokoningii exhibited the ability to induce morphological changes in dendritic cells and enhance the expression of the dendritic cell surface characteristic molecules CD11c, CD86, CD80, and major histocompatibility complex II, which is also associated with NF-κB and MAPK signaling pathways ( Xu et al, 2016 ). These characteristics indicate that FcEPS is a promising anti-inflammatory agent.…”

Structure and Anti-Tumor Activities of Exopolysaccharides from Alternaria mali Roberts

“…In long-term studies, several polysaccharides extracted from fungi, such as polysaccharides from Grifolafrondosa [18], Ganodermalucidum [19], Gastrodiaelata Blume [20], Trichodermapseudokoningii [6,21], and Flammulinavelutipes [22], have exhibited strong biological activity, especially anti-tumor and immunoregulatory activity [10,23,24,25,26]. We have been devoted to exploring polysaccharides with antitumor activity from various fungi for a long time [6,7,27,28,29].…”