Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Guo, Xu; Gao, Congying; Yang, Dong‐Hua; Li, Shenglong

doi:10.1016/j.drup.2023.100937

Cited by 76 publications

(31 citation statements)

References 178 publications

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“…In addition to the use of bioactive molecules to regulate ncRNAs, ncRNA inhibitors or mimics can also be supplied to target cells via liposomes or nanoparticle delivery systems, with the goal of restoring or enhancing the tumor suppressor function of ncRNAs. Extracellular vesicles, which can exist steadily and perform a variety of functions in the TME and immunological infiltration, are one of the main delivery substances in liposomes (Gao et al, 2022; Guo et al, 2023; Li, 2021; Yue et al, 2022). Specifically, extracellular nanovesicles circ‐0000190 in OS cells show the ability to boost miR‐767‐5p to control TET 1 and limit the growth of OS as well as weaken OS cell motility, proliferation, and invasion (Li, Pei, et al, 2020).…”

Section: The Promising Roles Of Targeting Ncrnas In Os Therapymentioning

confidence: 99%

Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA

Chen,

Gong,

Zhou

et al. 2024

Drug Development Research

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Osteosarcoma (OS) is a primary malignant bone tumor and is prevalent in children, adolescents, and elderly individuals. It has the characteristics of high invasion and metastasis. Neoadjuvant chemotherapy combined with surgical resection is the most commonly used treatment for OS. However, the efficacy of OS is considerably diminished by chemotherapy resistance. In recent years, noncoding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are hot topics in the field of chemotherapy resistance research. Several studies have demonstrated that ncRNAs are substantially associated with chemoresistance in OS. Thus, the present study overviews the abnormally expressed ncRNAs in OS and the molecular mechanisms involved in chemoresistance, with an emphasis on their function in promoting or inhibiting chemoresistance. ncRNAs are expected to become potential therapeutic targets for overcoming drug resistance and predictive biomarkers in OS, which are of great significance for enhancing the therapeutic effect and improving the prognosis.

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Section: The Promising Roles Of Targeting Ncrnas In Os Therapymentioning

confidence: 99%

Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA

Chen,

Gong,

Zhou

et al. 2024

Drug Development Research

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“…As a kind of innate or acquired resistance, chemoresistance is the main cause of the clinical failure of chemotherapy. 88 One of the chemoresistance mechanisms is the overexpression of multidrug resistance (MDR) genes. 89 Among their expressed productions, a large superfamily of transporters named ATP-binding cassette (ABC) transporters, such as breast cancer resistance protein (BCRP), P-glycoprotein (P-gp), and multidrug-resistance protein (MRP), can pump out chemotherapy drugs, and reduce the accumulation of drugs in cells.…”

Section: Rna-cleaving Dnazymes For Gene Therapymentioning

confidence: 99%

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

Gao¹,

Liu²,

Huo³

et al. 2023

Nanoscale

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“…Chemotherapy resistance is a common challenge in tumor therapy because tumor cells acquire resistance to chemotherapeutic drugs and are unable to effectively kill tumor cells 16,17 . This phenomenon is usually caused by biochemical mechanisms within the tumor cells, such as drug efflux, drug catabolism, DNA repair 18–23 . In the field of oncology, NPs have been extensively studied as drug carriers to overcome the problem of drug resistance faced by conventional chemotherapeutic agents 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance

Cited by 76 publications

References 178 publications

Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA

Deciphering chemoresistance in osteosarcoma: Unveiling regulatory mechanisms and function through the lens of noncoding RNA

RNA-cleaving DNAzymes for accurate biosensing and gene therapy

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

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