Exosomal non coding RNAs as a novel target for diabetes mellitus and its complications

Sufianov, Albert; Kostin, Andrey; Begliarzade, Sema; Kudriashov, Valentin; Ilyasova, Tatiana; Liang, Yanchao; Mukhamedzyanov, Albert; Beylerli, Ozal

doi:10.1016/j.ncrna.2023.02.001

Cited by 23 publications

(18 citation statements)

References 179 publications

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“…Recent studies have identified a variety of long non-coding RNAs (lncRNAs) in exosomes. 123 , 124 Li et al have indicated that mesenchymal stem cells-derived lncRNA H19 accelerates wound healing by enhancing PTEN via microRNA-152-3p in DFUs. 125 Yang et al also showed that HF-MSC-Exo markedly suppressed the production of IL-1β and IL-18 and activation of Caspase-1 and decreased the presence of the NLRP3 inflammasome in HaCaT cells.…”

Section: Suppressing Pyroptosis-dependent Signaling In Therapeutic Re...mentioning

confidence: 99%

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

Al Mamun,

Shao,

Geng

et al. 2024

JIR

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Pyroptosis defines a form of pro-inflammatory-dependent programmed cell death triggered by gasdermin proteins, which creates cytoplasmic pores and promotes the activation and accumulation of immune cells by releasing several pro-inflammatory mediators and immunogenic substances upon cell rupture. Pyroptosis comprises canonical (mediated by Caspase-1) and non-canonical (mediated by Caspase-4/5/11) molecular signaling pathways. Numerous studies have explored the contributory roles of inflammasome and pyroptosis in the progression of multiple pathological conditions such as tumors, nerve injury, inflammatory diseases and metabolic disorders. Accumulating evidence indicates that the activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome results in the activation of pyroptosis and inflammation. Current evidence suggests that pyroptosis-dependent cell death plays a progressive role in the development of diabetic complications including diabetic wound healing (DWH) and diabetic foot ulcers (DFUs). This review presents a brief overview of the molecular mechanisms underlying pyroptosis and addresses the current research on pyroptosis-dependent signaling pathways in the context of DWH. In this review, we also present some prospective therapeutic compounds/agents that can target pyroptotic signaling pathways, which may serve as new strategies for the effective treatment and management of diabetic wounds.

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Section: Suppressing Pyroptosis-dependent Signaling In Therapeutic Re...mentioning

confidence: 99%

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

Al Mamun,

Shao,

Geng

et al. 2024

JIR

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“…LncRNAs structures are heterogeneous, with or without poly A tails [ [1] , [2] , [3] , [4] ]. Compared with mRNA, the expression level of lncRNA is lower, and the conservation between species is poor, and its expression has obvious tissue or cell specificity, mainly localized in the nucleus, and a few localized in the cytoplasm [ 1 , 3 , 5 ].…”

Section: Lncrnas Overviewmentioning

confidence: 99%

“…Long non-coding RNAs (lncRNAs) was originally considered as a by-product of RNA polymerase II (Pol II) transcription, and was regarded as the "noise" of genome transcription because it cannot encode protein [ [1] , [2] , [3] , [4] , [5] ]. In recent years, with the help of high-throughput omics technology, more and more lncRNAs have been annotated.…”

Section: Introductionmentioning

confidence: 99%

“…A large number of studies have shown that lncRNAs are widely involved in the regulation of gene expression, in cell proliferation, differentiation, apoptosis and tumor progression. important role in development [ [1] , [2] , [3] , [4] , [5] ]. The results of the latest research show that lncRNAs can still be translated into small molecular polypeptides, which extends the function of polypeptide-encoding genes in the human genome to a certain extent [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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The role of long non-coding RNAs in the development of adipose cells

Sufianov

Beilerli

Kudriashov

et al. 2023

Non-coding RNA Research

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“…Ще один механізм, який може пояснювати корисність МСК у лікуванні ЦД, полягає в їхній здатності до інгібування апоптозу (програмованої клітинної смерті) інсулінових клітин в підшлунковій залозі, що може допомогти під-тримувати їх кількість та забезпечити стійкий функціональний ефект [16].…”

Section: результати та їх обговоренняunclassified

The Use of Stem Cells in the Treatment of Diabetes

Cui,

Shemet,

Ziablitsev

2023

Med. Sci. of Ukr.

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Background. The article is devoted to an analytical review of the methods of using stem cells in the treatment of diabetes mellitus (DM). Aim: to analyze, based on the data of the literature, the prospects of using stem cells for the treatment of DM. Materials and methods. Review of scientific literature in the international electronic scientometric databases PubMed, Scopus, Web of Science by keywords for the period 20017-2023. The search was carried out by three independent authors. 98 sources were selected for analysis, of which 33 were used that met the search criteria. Results. DM is a serious problem for the health care system worldwide, which requires the development of new innovative and effective therapeutic approaches. The use of stem cells is one such promising strategy for solving this problem. The ability of stem cells to differentiate into various body cells, including beta cells of the pancreas, was analyzed. Animal studies have demonstrated the ability to improve insulin synthesis and lower blood glucose levels. The use of stem cells in the treatment of DM is not a widespread approach and requires additional clinical studies. General information on the use of stem cells in the treatment of diabetes is presented and the prospects of this method of therapy are outlined. Conclusions. The use of stem cells in the treatment of diabetes is a promising technology that may open new opportunities for the treatment of this disease. However, more research needs to be done, a number of technical, ethical, and legal issues need to be addressed, as well as regulatory standards for the production and use of stem cells.

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Exosomal non coding RNAs as a novel target for diabetes mellitus and its complications

Cited by 23 publications

References 179 publications

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

The Mechanism of Pyroptosis and Its Application Prospect in Diabetic Wound Healing

The role of long non-coding RNAs in the development of adipose cells

The Use of Stem Cells in the Treatment of Diabetes

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