Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets

Hussen, Bashdar Mahmud; Abdullah, Sara Tharwat; Abdullah, Snur Rasool; Younis, Yousif Mohammed; Hidayat, Hazha Jamal; Rasul, Mohammed Fatih; Mohamadtahr, Sayran

doi:10.1016/j.ncrna.2023.09.001

Cited by 5 publications

(1 citation statement)

References 260 publications

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“…Exosomal MALAT1 promotes the malignant metastasis of CRC cells by adsorbing miRNA‐26a/26b 52 et al. And, Recent reports have shown that mirNA‐335‐5p, miRNA‐135b‐5p, miRNA‐934, miRNA‐106b, miRNA‐27b‐3p, mirNA‐106b‐3p, miRNA‐221/222 and miRNA‐203 are all upregulated in CRC tissue cells Promotes the transfer of a cell and the attack, but the miRNA‐3940‐5 p, micrornas‐16‐5 p, the miRNA‐424, the miRNA‐140‐3‐p in CRC expression by means of tissue cells are inhibits cell metastasis and invasion, promoted the apoptosis 53 . Among them, there is a lack of studies on miR‐1270, which is supplemented in this paper.…”

Section: Discussionmentioning

confidence: 99%

The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells

Jin,

Sun,

Chen

et al. 2024

Cancer Medicine

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BackgroundColorectal cancer (CRC), known as prevalent cancer, has risen to be the leading cause of cancer‐related death. Engineered exosomes had attracted much attention since they acted as carriers to deliver small molecule drugs, therapeutic nucleic acids, and polypeptides to treat a series of cancers.Methods and ResultsHere, we found that the PKH‐26 labeled exosomes, which were derived from the CRC cells, could be efficiently absorbed by SW1116 cells and had an abundant fluorescence distribution in tumors, compared with the exosomes derived from mesenchymal stem cells (MSC) and HepG2 cells. This Research demonstrated that engineered CRC‐exosomes loaded with functional miR‐1270 (Exo‐miR‐1270) enriched in miR‐1270 strongly inhibited the proliferation by CCK‐8 and EdU assays, migration by wound‐healing and transwell assays, and promoted the apoptosis for CRC cells through flow cytometry. MiR‐1270 overexpression delivered by CRC exosomes contributed to inhibiting the tumor growth potential of CRC in vivo and increasing the overall survival of the mice. Moreover, the safety evaluation results showed that CRC‐exosomes loaded with functional miR‐1270‐mimics had no toxicity for other organs by histopathological analysis and no influence on the vital chemistry and hematology parameters for mice in vivo safety evaluation.ConclusionThese results indicate that Exo‐miR‐1270 can effectively treat CRC tumors by intravenous administration. Our work provided a foundation that the homologous tumor‐derived exosomes mediated miRNA delivery for the treatment of CRC.

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Section: Discussionmentioning

confidence: 99%

The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells

Jin,

Sun,

Chen

et al. 2024

Cancer Medicine

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Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Udaipuria,

Bhattacharya

2024

Biopolymers

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Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH‐responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon‐specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli‐responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.

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Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities

Li,

Zhou,

Wang

et al. 2024

MedComm

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Exosomes can regulate the malignant progression of tumors by carrying a variety of genetic information and transmitting it to target cells. Recent studies indicate that exosomal circular RNAs (circRNAs) regulate multiple biological processes in carcinogenesis, such as tumor growth, metastasis, epithelial–mesenchymal transition, drug resistance, autophagy, metabolism, angiogenesis, and immune escape. In the tumor microenvironment (TME), exosomal circRNAs can be transferred among tumor cells, endothelial cells, cancer‐associated fibroblasts, immune cells, and microbiota, affecting tumor initiation and progression. Due to the high stability and widespread presence of exosomal circRNAs, they hold promise as biomarkers for tumor diagnosis and prognosis prediction in blood and urine. In addition, designing nanoparticles targeting exosomal circRNAs and utilizing exosomal circRNAs derived from immune cells or stem cells provide new strategies for cancer therapy. In this review, we examined the crucial role of exosomal circRNAs in regulating tumor‐related signaling pathways and summarized the transmission of exosomal circRNAs between various types of cells and their impact on the TME. Finally, our review highlights the potential of exosomal circRNAs as diagnostic and prognostic prediction biomarkers, as well as suggesting new strategies for clinical therapy.

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Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets

Cited by 5 publications

References 260 publications

The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells

The homologous tumor‐derived‐exosomes loaded with miR‐1270 selectively enhanced the suppression effect for colorectal cancer cells

Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities

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