Exosomal non-coding RNAs’ role in immune regulation and potential therapeutic applications

Saadh, Mohamed J.; Kiasari, Bahman Abedi; Shahrtash, S.A.; Arias-Gonzáles, José Luis; Chaitanya, M.V.N.L.; Cotrina-Aliaga, Juan Carlos; Kadham, Mustafa Jawad; Sârbu, Ionela; Akhavan‐Sigari, Reza

doi:10.1016/j.prp.2023.154522

Cited by 3 publications

(2 citation statements)

References 82 publications

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“…CRNDE-h interacts with the PPXY motif of RORγt, a transcription factor, thereby inhibiting the Itch-mediated ubiquitination and degradation of RORγt. By mediating the tumor–stroma immune interplay via exosomes, CRNDE may represent a potential target for CRC immunotherapy [ 61 , 103 , 104 ].…”

Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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“…These EVs serve as an efficient delivery system, transferring bioactive signals to target cells (Ofir-Birin & Regev-Rudzki, 2019;Szempruch et al, 2016). Exosomal RNAs have been shown to exert regulatory control over gene expression and function in recipient cells, influencing various physiological and metabolic processes (Saadh et al, 2023). However, the specific biological functions of long noncoding RNAs (lncRNAs), which constitute prominent cargo within EVs, have remained unclear.…”

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confidence: 99%

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

et al. 2023

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Overcoming challenges associated with malaria eradication proves to be a formidable task due to the complicated life cycle exhibited by the malaria parasite and the lack of safe and enduring vaccines against malaria. Investigating the interplay between Plasmodium parasites and their mammalian hosts is crucial for the development of novel vaccines. Long noncoding RNAs (lncRNAs) derived from Plasmodium parasites or host cells have emerged as potential signaling molecules involved in the trafficking of proteins, RNA (mRNAs, miRNAs, and ncRNAs), and DNA. These lncRNAs facilitate the interaction between hosts and parasites, impacting normal physiology or pathology in malaria‐infected individuals. Moreover, they possess the capacity to regulate immune responses and associated signaling pathways, thus potentially influencing chromatin organization, epigenetic modifications, mRNA processing, splicing, and translation. However, the functional role of exosomal lncRNAs in malaria remains poorly understood. This review offers a comprehensive analysis of lncRNA and exosomal lncRNA profiles during malaria infection. It presents an overview of recent progress in elucidating the involvement of exosomal lncRNAs in host–parasite interactions. Additionally, potential exosomal lncRNAs linked to the domains of innate and adaptive immunity in the context of malaria are proposed. These findings may contribute to the discovery of new diagnostic and therapeutic strategies for malaria. Furthermore, the need for additional research was highlighted that aimed to elucidate the mechanisms underlying lncRNA transportation into host cells and their targeting of specific genes to regulate the host's immune response. This knowledge gap presents an opportunity for future investigations, offering innovative approaches to enhance malarial control.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule‐RNA Interactions RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications RNA in Disease and Development > RNA in Disease

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The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

Zhang,

Liu,

Wang

et al. 2024

Experimental Neurology

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Exosomal non-coding RNAs’ role in immune regulation and potential therapeutic applications

Cited by 3 publications

References 82 publications

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Exosome‐derived long noncoding RNAs: Mediators of host–Plasmodium parasite communication

The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair

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