Exosome-based strategy for degenerative disease in orthopedics: Recent progress and perspectives

Wu, Rongjie; Li, Haotao; Sun, Chuanwei; Liu, Jialin; Chen, Duanyong; Yu, Haiyang; Huang, Zhemin; Lin, Sien; Chen, Yong; Zheng, Qiujian

doi:10.1016/j.jot.2022.05.009

Cited by 18 publications

(12 citation statements)

References 105 publications

(133 reference statements)

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“…Bone homeostasis is dynamically maintained by the balance of bone formation and bone absorption, and alterations in intestinal microbiota composition and metabolites are implicated in impaired bone metabolism by affecting mineral absorption and stimulating inflammation [198,199]. Abnormal bone loss can be caused by aging, hormonal imbalance, and dietary factors, all of which have been documented to be accompanied by microbiome changes [41,[200][201][202][203]. In addition, a recent study by Liu et al reported that gut microbiota from healthy children alleviated bone loss and altered bone metabolism in ovariectomy-mice by reversing the ovariectomy-induced reduction of A. muciniphila.…”

Section: Bevs In Pathogenesismentioning

confidence: 99%

Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities

Luo

Chang

Liang

et al. 2023

iMeta

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In recent decades, accumulating research on the interactions between microbiome homeostasis and host health has broadened new frontiers in delineating the molecular mechanisms of disease pathogenesis and developing novel therapeutic strategies. By transporting proteins, nucleic acids, lipids, and metabolites in their versatile bioactive molecules, extracellular vesicles (EVs), natural bioactive cell‐secreted nanoparticles, may be key mediators of microbiota–host communications. In addition to their positive and negative roles in diverse physiological and pathological processes, there is considerable evidence to implicate EVs secreted by bacteria (bacterial EVs [BEVs]) in the onset and progression of various diseases, including gastrointestinal, respiratory, dermatological, neurological, and musculoskeletal diseases, as well as in cancer. Moreover, an increasing number of studies have explored BEV‐based platforms to design novel biomedical diagnostic and therapeutic strategies. Hence, in this review, we highlight the recent advances in BEV biogenesis, composition, biofunctions, and their potential involvement in disease pathologies. Furthermore, we introduce the current and emerging clinical applications of BEVs in diagnostic analytics, vaccine design, and novel therapeutic development.

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Section: Bevs In Pathogenesismentioning

confidence: 99%

Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities

Luo

Chang

Liang

et al. 2023

iMeta

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“…Therefore, it is necessary to develop a series of advanced and reasonable EVs isolation, extraction and identification systems to standardize the study of EVs, which will help to form and maintain GMP standards 167,168 Additionally, naturally derived EVs presented with the characteristics of weak targeting and quick clearance, leading to poor therapeutic effects. 169 To overcome the challenges that block the clinical applications of EVs, they are often modified into engineered EVs. 170 At present, the main way of engineering EVs is EVs drug loading.…”

Section: Challenges and Prospectsmentioning

confidence: 99%

“…The following limitations need to be addressed: (i) lack of satisfactory parental cells; (ii) lack of cost‐effective EVs extraction process, especially lack of standardized operating specifications to ensure EVs production, purity, and function with good reproducibility; (iii) lack efficient EVs drug loading methods; (iv) lack of mature EVs storage and transport system; and (v) the safety of EVs in vivo is still controversial. Therefore, it is necessary to develop a series of advanced and reasonable EVs isolation, extraction and identification systems to standardize the study of EVs, which will help to form and maintain GMP standards 167,168 Additionally, naturally derived EVs presented with the characteristics of weak targeting and quick clearance, leading to poor therapeutic effects 169 . To overcome the challenges that block the clinical applications of EVs, they are often modified into engineered EVs 170 .…”

Section: Challenges and Prospectsmentioning

confidence: 99%

Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Huang,

Liu,

Wang

et al. 2023

Orthopaedic Surgery

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Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells‐derived extracellular vesicles (MSCs‐EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs‐EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs‐EVs in cartilage repair.

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“…In spite of the enduring utilization of traditional medical approaches, such as physical therapy, pharmacological intervention, and surgical procedures, aimed at impeding or reversing the degenerative process, their effectiveness remains constrained in altering the progression of degenerative diseases. ( Wu et al, 2022 ). The bone, osteochondral, and cartilage regions, extensively utilized in the human body, exhibit constrained regenerative capacity due to compromised vasculature in severe defects and the avascular nature of cartilage.…”

Section: Introductionmentioning

confidence: 99%

Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseases

Yue,

Dai,

Wei

et al. 2024

Front. Bioeng. Biotechnol.

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Degenerative orthopaedic diseases pose a notable worldwide public health issue attributable to the global aging population. Conventional medical approaches, encompassing physical therapy, pharmaceutical interventions, and surgical methods, face obstacles in halting or reversing the degenerative process. In recent times, exosome-based therapy has gained widespread acceptance and popularity as an effective treatment for degenerative orthopaedic diseases. This therapeutic approach holds the potential for “cell-free” tissue regeneration. Exosomes, membranous vesicles resulting from the fusion of intracellular multivesicles with the cell membrane, are released into the extracellular matrix. Addressing challenges such as the rapid elimination of natural exosomes in vivo and the limitation of drug concentration can be effectively achieved through various strategies, including engineering modification, gene overexpression modification, and biomaterial binding. This review provides a concise overview of the source, classification, and preparation methods of exosomes, followed by an in-depth analysis of their functions and potential applications. Furthermore, the review explores various strategies for utilizing exosomes in the treatment of degenerative orthopaedic diseases, encompassing engineering modification, gene overexpression, and biomaterial binding. The primary objective is to provide a fresh viewpoint on the utilization of exosomes in addressing bone degenerative conditions and to support the practical application of exosomes in the theranosis of degenerative orthopaedic diseases.

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Exosome-based strategy for degenerative disease in orthopedics: Recent progress and perspectives

Cited by 18 publications

References 105 publications

Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities

Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities

Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Unlocking the potential of exosomes: a breakthrough in the theranosis of degenerative orthopaedic diseases

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