Exosome bound microRNAs transcriptionally regulate embryo-endometrial dialogue impacting implantation potential for AMA patients

Patton, A.L.; McCallie, Blair R.; Parks, Jason C.; Schoolcraft, William B.; Katz‐Jaffe, Mandy G.

doi:10.1016/j.fertnstert.2015.07.964

Cited by 9 publications

(9 citation statements)

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“…Placenta-derived EVs are reported to induce vasculogenesis and angiogenesis through an oxygen-sensing mechanism, especially under the hypoxic conditions during the early stages of pregnancy. Furthermore, vascular endothelial growth factor A (VEGFA), an angiogenesis stimulator and vessel growth factor, along with exosomal miRNAs, is released by the implanted embryo to regulate blood supply [63]. Both, maternal and umbilical serum exosomes enhance endothelial cell proliferation, migration, and tube formation.…”

Section: The Angiogenic Potential Of Exosomes In Pregnancymentioning

confidence: 99%

Exosomes as Messengers between Mother and Fetus in Pregnancy

Czernek

Duechler

2020

IJMS

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The ability of exosomes to transport different molecular cargoes and their ability to influence various physiological factors is already well known. An exciting area of research explores the functions of exosomes in healthy and pathological pregnancies. Placenta-derived exosomes were identified in the maternal circulation during pregnancy and their contribution in the crosstalk between mother and fetus are now starting to become defined. In this review, we will try to summarize actual knowledge about this topic and to answer the question of how important exosomes are for a healthy pregnancy.

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Section: The Angiogenic Potential Of Exosomes In Pregnancymentioning

confidence: 99%

Exosomes as Messengers between Mother and Fetus in Pregnancy

Czernek

Duechler

2020

IJMS

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“…In the recent years, several studies have revealed that exosomes could be released from various parts of the female reproductive tract, including uterine, oviducts epithelium, endometrium, as well as preimplantation embryos, the placenta trophoblastic cells . It is mentioned that exosomes play a substantial role in transmitting specific cargo molecules in the reproductive tract to modulate transcription and translational activity, granulosa cells proliferation and differentiation, cumulus expansion, gametogenesis, normal follicular growth, oocyte maturation, fertilization rate, embryo development, blastocyst formation and implantation, in pregnancy outcome and fertility .…”

Section: The Role Of Extracellular Vesicles In Female Physiological Pmentioning

confidence: 99%

“…Studies have shown that endometrial epithelium release vesicles that contribute to the transfer of miRNA and connective molecules both to blastocysts and endometrium around the uterus could substantially affect the implantation and fertility outcomes . For instance, vascular endothelial growth factor A (VEGFA), the angiogenesis stimulator and the growth factor discharged by the implanting embryo and the receiving endometrium along with exosomal miRNAs are substantial regulators of successful implantation . Exosomes derived from ovine uterine flushing have been shown to stimulate trophectoderm cells to proliferate and secrete interferon tau (the pregnancy recognition signal) harmoniously with the regulation of TLR‐mediated cell signaling .…”

Section: Use Of Extracellular Vesicles For Diagnostic Purposes In Femmentioning

confidence: 99%

Physiological impact of extracellular vesicles on female reproductive system; highlights to possible restorative effects on female age‐related fertility

et al. 2019

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An alternative mechanism of cell-to-cell communication via extracellular vesicles (EVs) has recently raised increasing attention. EVs are spherical structures comprising exosomes and microvesicles, capable of transferring regulatory molecules and genetic information from one cell to another. EVs act as modulators which can alter a wide spectrum of functions at the cellular level in the recipient cells, taking part in a variety of biological processes in both physiological and pathological conditions. Alteration in EVs content, notably exosomes, was reported during cellular senescence and in patients with age-related diseases. Most studies reported regulating the impacts of exosomes on fertility and pregnancy outcomes via their capability in carrying developmental signaling molecules like proteins, RNA cargos, influencing gene expressions, affecting growth, and development of embryos during aging. Alterations in the exosomal content and functions can influence the reproductive performance in human and animals as conveyors of senescence signals from outside of the cells. This review aimed to summarize evidence on the role of EVs on modulating fertility, early embryonic development, maternal-embryo crosstalk for the recognition, and maintenance of pregnancy during maternal aging. Advanced clinical studies are required to strengthen the findings that the benefit of exosomes can be extended to subjects undergoing reproductive aging.

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“…In this context, exosomes transport different cargos and, thus, play an important role in the regulation of gene and protein expression, proliferation and differentiation of granulosa cells and follicles, oocyte growth, fertilization, implantation, embryo development, and successful pregnancy [ 38 , 39 ]. Due to exosomes’ diagnostic and therapeutic potential in reproductive disorders, great attention has shifted toward the role of exosomes over the last two decades [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

Esfandyari

Elkafas

Chugh

et al. 2021

IJMS

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Cell–cell communication is an essential mechanism for the maintenance and development of various organs, including the female reproductive system. Today, it is well-known that the function of the female reproductive system and successful pregnancy are related to appropriate follicular growth, oogenesis, implantation, embryo development, and proper fertilization, dependent on the main regulators of cellular crosstalk, exosomes. During exosome synthesis, selective packaging of different factors into these vesicles happens within the originating cells. Therefore, exosomes contain both genetic and proteomic data that could be applied as biomarkers or therapeutic targets in pregnancy-associated disorders or placental functions. In this context, the present review aims to compile information about the potential exosomes with key molecular cargos that are dysregulated in female reproductive diseases which lead to infertility, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), Asherman syndrome, endometriosis, endometrial cancer, cervical cancer, ovarian cancer, and preeclampsia, as well as signaling pathways related to the regulation of the reproductive system and pregnancy outcome during these pathological conditions. This review might help us realize the etiology of reproductive dysfunction and improve the early diagnosis and treatment of the related complications.

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Exosome bound microRNAs transcriptionally regulate embryo-endometrial dialogue impacting implantation potential for AMA patients

Cited by 9 publications

References 0 publications

Exosomes as Messengers between Mother and Fetus in Pregnancy

Exosomes as Messengers between Mother and Fetus in Pregnancy

Physiological impact of extracellular vesicles on female reproductive system; highlights to possible restorative effects on female age‐related fertility

Exosomes as Biomarkers for Female Reproductive Diseases Diagnosis and Therapy

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