Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Guo, Weihua; Li, Yashan; Pang, Wei; Shen, Hong

doi:10.1016/j.ymthe.2020.06.003

Cited by 50 publications

(34 citation statements)

References 121 publications

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“…In tumor microenvironments, the interaction between macrophages and other cells in osteosarcoma TME participates in the disease progress of osteosarcoma. As a part of their survival strategies, tumor cells often resort to cunning mechanisms to manipulate the macrophages and create an immunosuppressive, tumor-promoting microenvironment ( 85 ). Some studies demonstrated that osteosarcoma cells enhanced the recruitment of macrophages by secretion of cytokine.…”

Section: Macrophages and Osteosarcomamentioning

confidence: 99%

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Luo

Wang

et al. 2020

Front. Oncol.

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Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies.

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Section: Macrophages and Osteosarcomamentioning

confidence: 99%

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Luo

Wang

et al. 2020

Front. Oncol.

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“…In light of the crucial crosstalk between immune cells and tumor cells, mounting studies have proposed a promising therapeutic strategy involving alteration of the tumor state via exosomes engineering to achieve therapeutic goals [ 277 ]. Previous studies reported that exosomes avoid clearance by the human immune system because they carry CD47 in their membranes.…”

Section: Clinical Applications Of Exosomes In Cancermentioning

confidence: 99%

Isolation and characterization of exosomes for cancer research

et al. 2020

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Exosomes are a subset of extracellular vesicles that carry specific combinations of proteins, nucleic acids, metabolites, and lipids. Mounting evidence suggests that exosomes participate in intercellular communication and act as important molecular vehicles in the regulation of numerous physiological and pathological processes, including cancer development. Exosomes are released by various cell types under both normal and pathological conditions, and they can be found in multiple bodily fluids. Moreover, exosomes carrying a wide variety of important macromolecules provide a window into altered cellular or tissue states. Their presence in biological fluids renders them an attractive, minimally invasive approach for liquid biopsies with potential biomarkers for cancer diagnosis, prediction, and surveillance. Due to their biocompatibility and low immunogenicity and cytotoxicity, exosomes have potential clinical applications in the development of innovative therapeutic approaches. Here, we summarize recent advances in various technologies for exosome isolation for cancer research. We outline the functions of exosomes in regulating tumor metastasis, drug resistance, and immune modulation in the context of cancer development. Finally, we discuss prospects and challenges for the clinical development of exosome-based liquid biopsies and therapeutics.

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“…Many studies have shown that exosomes, i.e., 40- to 100-nm vesicles containing nucleic acids, proteins, and lipids, could be used as tumor biomarkers. 90 , 91 , 92 Various biomarkers for different types of cancer have been identified with exosome proteomics ( Figure 5 ). Thrombospondin-1 (THBS1), fibulin-1 (FBLN1), and fibrinogen gamma chain (FGG) were identified as clinical biomarkers for liver cancer.…”

Section: The Application Of Quantitative Proteomics In Clinical Diagnosis and Treatmentmentioning

confidence: 99%

Quantitative proteomics characterization of cancer biomarkers and treatment

Yang

Shi

Zhang

et al. 2021

Molecular Therapy - Oncolytics

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Cancer accounted for 16% of all death worldwide in 2018. Significant progress has been made in understanding tumor occurrence, progression, diagnosis, treatment, and prognosis at the molecular level. However, genomics changes cannot truly reflect the state of protein activity in the body due to the poor correlation between genes and proteins. Quantitative proteomics, capable of quantifying the relatively different protein abundance in cancer patients, has been increasingly adopted in cancer research. Quantitative proteomics has great application potentials, including cancer diagnosis, personalized therapeutic drug selection, real-time therapeutic effects and toxicity evaluation, prognosis and drug resistance evaluation, and new therapeutic target discovery. In this review, the development, testing samples, and detection methods of quantitative proteomics are introduced. The biomarkers identified by quantitative proteomics for clinical diagnosis, prognosis, and drug resistance are reviewed. The challenges and prospects of quantitative proteomics for personalized medicine are also discussed.

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Exosomes: A Potential Therapeutic Tool Targeting Communications between Tumor Cells and Macrophages

Cited by 50 publications

References 121 publications

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy

Isolation and characterization of exosomes for cancer research

Quantitative proteomics characterization of cancer biomarkers and treatment

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