Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Prevent Acidic pH-Induced Damage in Human Nucleus Pulposus Cells

Li, Ming; Li, Ruoyu; Yang, Sidong; Yang, Dalong; Gao, Xianda; Sun, Jia-yuan; Ding, Wenyuan; Ma, Lei

doi:10.12659/msm.922928

Cited by 24 publications

(24 citation statements)

References 34 publications

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“…The application of MSCs avoids the problems associated with intact cell transplantation, such as immune rejection, infection, and non-directed cell differentiation (Lou et al, 2017). Exosomes secreted by MSCs from bone marrow, adipose, umbilical cord can all promote tissue regeneration and repair (Zhou et al, 2019;Li et al, 2020a;Zhang et al, 2021c). MSCs of different ages can regulate each other through exosomes, while younger MSC-Exos can enhance the proliferation and osteogenic differentiation of older MSCs (Jia et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Liang

Han

Hai

et al. 2022

Front. Cell Dev. Biol.

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Exosomes are extracellular vesicles formed by various donor cells that regulate gene expression and cellular function in recipient cells. Exosomes derived from mesenchymal stem cells (MSC-Exos) perform the regulatory function of stem cells by transporting proteins, nucleic acids, and lipids. Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, and it is characterized by a decreased number of nucleus pulposus cells, extracellular matrix decomposition, aging of the annulus fibrosus, and cartilage endplate calcification. Besides, nutrient transport and structural repair of intervertebral discs depend on bone and cartilage and are closely related to the state of the bone. Trauma, disease and aging can all cause bone injury. However, there is a lack of effective drugs against IDD and bone injury. Recent MSC-Exos fine tuning has led to significant progress in the IDD treatment and bone repair and regeneration. In this review, we looked at the uniqueness of MSC-Exos, and the potential treatment mechanisms of MSC-Exos with respect to IDD, bone defects and injuries.

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Section: Introductionmentioning

confidence: 99%

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Liang

Han

Hai

et al. 2022

Front. Cell Dev. Biol.

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“…Liao et al [110] In vitro/In vivo Reduction in the apoptotic NPCs after treatment with healthy exosomes compared to degenerated exosomes and attenuated IDD via activation of the AKT and autophagy pathways Luo et al [118] In The beneficial effect of MSC-derived exosomes on NPCs in acidic conditions has been recently demonstrated. BM-MSC-exosomes increased proliferation and attenuated the apoptosis of NPCs and enhanced the expression of ECM components [115]. Moreover, exosomes are able to inhibit IL-1β-induced inflammation and apoptosis in AF cells and they promote cell proliferation [116].…”

Section: Authors Type Of Study Potential Role Of Evs Resultsmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

et al. 2021

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Low back pain (LBP) is one of the most frequent symptoms associated with intervertebral disc degeneration (IDD) and affects more than 80% of the population, with strong psychosocial and economic impacts. The main cause of IDD is a reduction in the proteoglycan content within the nucleus pulposus (NP), eventually leading to the loss of disc hydration, microarchitecture, biochemical and mechanical properties. The use of mesenchymal stem cells (MSCs) has recently arisen as a promising therapy for IDD. According to numerous reports, MSCs mediate their regenerative and immunomodulatory effects mainly through paracrine mechanisms. Recent studies have suggested that extracellular vesicles (EVs) extracted from MSCs may be a promising alternative to cell therapy in regenerative medicine. EVs, including exosomes and microvesicles, are secreted by almost all cell types and have a fundamental role in intercellular communication. Early results have demonstrated the therapeutic potential of MSCs-derived EVs for the treatment of IDD through the promotion of tissue regeneration, cell proliferation, reduction in apoptosis and modulation of the inflammatory response. The aim of this review is to focus on the biological properties, function, and regulatory properties of different signaling pathways of MSCs-derived exosomes, highlighting their potential applicability as an alternative cell-free therapy for IDD.

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“…In previous studies, researchers used different in vitro cellular challenges (including IL-1β) ( Zhu L. et al, 2020 ; Li Z.-q. et al, 2020 ), high glucose ( Qi et al, 2019 ), LPS ( Zhang J. et al, 2020 ), advanced glycation end products (AGEs) ( Liao et al, 2019a ), hydrogen peroxide (H 2 O 2 ) ( Bari et al, 2018 ; Xia et al, 2019 ), TNF-ɑ ( Cheng et al, 2018 ; Zhu G. et al, 2020 ; Yuan et al, 2020 ), tert-butyl hydroperoxide (TBHP) ( Xie et al, 2020 ), and acidic pH ( Li et al, 2020a )) to simulate the degenerative microenvironment. For these biochemical challenges, exosomes produced from MSCs have been shown to have a protective impact on NPCs via the mechanism of increasing the expression of chondrocytes, aggrecan, and collagen II in the extracellular matrix and decreasing matrix disintegration via the mechanism of the down-modulation of matrix-degrading enzymes.…”

Section: Impacts Of Msc-derived Exosomes On Ivddmentioning

confidence: 99%

“…Exosomal miR-21 restrains PTEN activity and thus regulates PI3K/Akt pathway in NPC apoptosis. Another study ( Li et al, 2020a ) demonstrated that MSC-derived exosomes were capable of preventing and attenuating NPC apoptosis by suppressing caspase-3 expression and alleviating caspase-3 cleavage triggered by acidic pH. In addition, Zhu G. et al (2020) discovered that exosomes originating from BMSCs inhibit fibrotic accumulation, ECM disintegration, NPC apoptosis, and alleviate the progress of IDD through miR-532–5p.…”

Section: Impacts Of Msc-derived Exosomes On Ivddmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration

Gao

et al. 2022

Front. Cell Dev. Biol.

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Intervertebral disc degeneration (IVDD) has been reported to be the most prevalent contributor to low back pain, posing a significant strain on the healthcare systems on a global scale. Currently, there are no approved therapies available for the prevention of the progressive degeneration of intervertebral disc (IVD); however, emerging regenerative strategies that aim to restore the normal structure of the disc have been fundamentally promising. In the last decade, mesenchymal stem cells (MSCs) have received a significant deal of interest for the treatment of IVDD due to their differentiation potential, immunoregulatory capabilities, and capability to be cultured and regulated in a favorable environment. Recent investigations show that the pleiotropic impacts of MSCs are regulated by the production of soluble paracrine factors. Exosomes play an important role in regulating such effects. In this review, we have summarized the current treatments for disc degenerative diseases and their limitations and highlighted the therapeutic role and its underlying mechanism of MSC-derived exosomes in IVDD, as well as the possible future developments for exosomes.

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Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Prevent Acidic pH-Induced Damage in Human Nucleus Pulposus Cells

Cited by 24 publications

References 34 publications

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Mesenchymal Stem Cell-Derived Exosomes as a Novel Strategy for the Treatment of Intervertebral Disc Degeneration

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