Exosomes derived from hypoxia-preconditioned mesenchymal stem cells (hypoMSCs-Exo): advantages in disease treatment

Dong, Jia; Wu, Bin; Tian, Weidong

doi:10.1007/s00441-023-03758-6

Cited by 5 publications

(2 citation statements)

References 54 publications

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“…One is a proinflammatory M1 phenotype that can secrete inflammatory factors and promote inflammation and the other one is an anti-inflammatory M2 phenotype that can secrete cytokines such as IL-10, IL-r𝛼, and TGF-𝛽 for potential anti-inflammation therapy. [69] Most importantly, under certain stimulation, the two types can be converted into each other. Encouragingly, HMNVs carrying a variety of bioactive substances originating from the sources cells can regulate the secretion of inflammatory factors and correspondingly reprogram macrophage types from M1 to M2, which play an invaluable role in alleviating inflammation in various diseases.…”

Section: Inflammatory Diseases Treatmentmentioning

confidence: 99%

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Sun,

Yang,

Fan

et al. 2023

Advanced Science

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Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics and artificially acquired advantages. However, the limited targeting ability, insufficient production yield, and low drug‐loading capability of natural simplex EVs have greatly hindered their development in clinical translation. Therefore, the establishment of multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability and flexibility has become the key to expanding the practical application of EVs. This timely review summarizes the current progress of HMNVs for biomedical applications. Different HMNVs preparation strategies including physical, chemical, and chimera approaches are first discussed. This review then individually describes the diverse types of HMNVs based on homologous or heterologous cell membrane substances, a fusion of cell membrane and liposome, as well as a fusion of cell membrane and bacterial membrane. Subsequently, a specific emphasis is placed on the highlight of biological applications of the HMNVs toward various diseases with representative examples. Finally, ongoing challenges and prospects of the currently developed HMNVs in clinical translational applications are briefly presented. This review will not only stimulate broad interest among researchers from diverse disciplines but also provide valuable insights for the development of promising nanoplatforms in precision medicine.

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Section: Inflammatory Diseases Treatmentmentioning

confidence: 99%

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Sun,

Yang,

Fan

et al. 2023

Advanced Science

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show abstract

“…The first phase, the early inflammatory phase, is mediated by M1 macrophages that secrete cytokines and chemokines to remove dead or injured cells through an inflammatory response [4,[16][17][18][19]. The second regenerative phase is mediated by M2 macrophages that secrete pro-fibrotic and anti-inflammatory cytokines, including IL-10 and TGF-β [20]. Also, the M2 macrophages promote angiogenesis and extracellular matrix (ECM) deposition through the secretion of VEGF.…”

Section: Immune Cell-derived Evsmentioning

confidence: 99%

Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration

Ghassemi,

Inouye,

Takhmazyan

et al. 2023

Gels

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Increased prevalence of cardiovascular disease and potentially life-threatening complications of myocardial infarction (MI) has led to emerging therapeutic approaches focusing on myocardial regeneration and restoration of physiologic function following infarction. Extracellular vesicle (EV) technology has gained attention owing to the biological potential to modulate cellular immune responses and promote the repair of damaged tissue. Also, EVs are involved in local and distant cellular communication following damage and play an important role in initiating the repair process. Vesicles derived from stem cells and cardiomyocytes (CM) are of particular interest due to their ability to promote cell growth, proliferation, and angiogenesis following MI. Although a promising candidate for myocardial repair, EV technology is limited by the short retention time of vesicles and rapid elimination by the body. There have been several successful attempts to address this shortcoming, which includes hydrogel technology for the sustained bioavailability of EVs. This review discusses and summarizes current understanding regarding EV technology in the context of myocardial repair.

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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

Sun,

Li,

Liu

et al. 2024

Front. Med.

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Exosomes derived from hypoxia-preconditioned mesenchymal stem cells (hypoMSCs-Exo): advantages in disease treatment

Cited by 5 publications

References 54 publications

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Beyond Extracellular Vesicles: Hybrid Membrane Nanovesicles as Emerging Advanced Tools for Biomedical Applications

Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

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