Exosomes derived from mesenchymal stem cells improved function and survival of neutrophils from severe congenital neutropenia patients in vitro

Mahmoudi, Mohammad; Taghavi-Farahabadi, Mahsa; Namaki, Saeed; Baghaei, Kaveh; Rayzan, Elham; Rezaei, Nima; Hashemi, Seyed Mahmoud

doi:10.1016/j.humimm.2019.10.006

Cited by 23 publications

(14 citation statements)

References 22 publications

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“…Indeed, MSCs increase recruitment and direct migration, increase life span and enhanced phagocytosis and respiratory burst activity of neutrophils. Effects of MSCs are dependent on soluble factors such as GM-CSF or INF-g (34), IL-8 and MIF (33) as well as exosomes secretion (35,36). MSCs can also display an indirect effect on neutrophil by modulating other immune cells as demonstrated by Hu et al showing that MSCs induced IL-17 production by activated T cells stimulate neutrophil phagocytic activity (37).…”

Section: Mscs and Inflammatory Response: A Question Of Cell Dialoguementioning

confidence: 99%

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

2021

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Mesenchymal stromal cells (MSCs) are currently widely used in cell based therapy regarding to their remarkable efficacy in controlling the inflammatory status in patients. Despite recent progress and encouraging results, inconstant therapeutic benefits are reported suggesting that significant breakthroughs in the understanding of MSCs immunomodulatory mechanisms of action remains to be investigated and certainly apprehended from original point of view. This review will focus on the recent findings regarding MSCs close relationship with the innate immune compartment, i.e. granulocytes and myeloid cells. The review will also consider the intercellular mechanism of communication involved, such as factor secretion, cell-cell contact, extracellular vesicles, mitochondria transfer and efferocytosis. Immune-like-properties of MSCs supporting part of their therapeutic effect in the clinical setting will be discussed, as well as their potentials (immunomodulatory, anti-bacterial, anti-inflammatory, anti-oxidant defenses and metabolic adaptation…) and effects mediated, such as cell polarization, differentiation, death and survival on various immune and tissue cell targets determinant in triggering tissue regeneration. Their metabolic properties in term of sensing, reacting and producing metabolites influencing tissue inflammation will be highlighted. The review will finally open to discussion how ongoing scientific advances on MSCs could be efficiently translated to clinic in chronic and age-related inflammatory diseases and the current limits and gaps that remain to be overcome to achieving tissue regeneration and rejuvenation.

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Section: Mscs and Inflammatory Response: A Question Of Cell Dialoguementioning

confidence: 99%

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

2021

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“…Evidence for functional reprogramming of neutrophils by TEX was reported in a recent paper showing that gastric-cancer-cell-derived sEVs enhanced PD-L1 expression of neutrophils, thereby suppressing the activity of T cells [47]. The concept that TEX interact with neutrophils and promote their activation is also supported by co-incubation studies leading to both pro-inflammatory [79] and anti-inflammatory profiles [80,81] depending on the source and cargo components of TEX. One effector for the promotion of pro-or anti-inflammatory responses by neutrophils is the release of granules [72].…”

Section: Effects Of Tex On Neutrophilsmentioning

confidence: 85%

Potential Roles of Tumor Cell- and Stroma Cell-Derived Small Extracellular Vesicles in Promoting a Pro-Angiogenic Tumor Microenvironment

Ludwig

Rubenich

Zaręba

et al. 2020

Cancers

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Extracellular vesicles (EVs) are produced and released by all cells and are present in all body fluids. They exist in a variety of sizes, however, small extracellular vesicles (sEVs), the EV subset with a size range from 30 to 150 nm, are of current interest. They are characterized by a distinct biogenesis and complex cargo composition, which reflects the cytosolic contents and cell-surface molecules of the parent cells. This cargo consists of proteins, nucleic acids, and lipids and is competent in inducing signaling cascades in recipient cells after surface interactions or in initiating the generation of a functional protein by delivering nucleic acids. Based on these characteristics, sEVs are now considered as important mediators of intercellular communication. One hallmark of sEVs is the promotion of angiogenesis. It was shown that sEVs interact with endothelial cells (ECs) and promote an angiogenic phenotype, ultimately leading to increased vascularization of solid tumors and disease progression. It was also shown that sEVs reprogram cells in the tumor microenvironment (TME) and act in a functionally cooperative fashion to promote angiogenesis by a paracrine mechanism involving the differential expression and secretion of angiogenic factors from other cell types. In this review, we will focus on the distinct functions of tumor-cell-derived sEVs (TEX) in promotion of angiogenesis and describe their potential as a therapeutic target for anti-angiogenic therapies. Also, we will focus on non-cancer stroma-cell-derived small extracellular vesicles and their potential role in stimulating a pro-angiogenic TME.

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“…Exosomes are thought to be superior over MSCs with regard to treatment-related safety [41]. A previous work suggested that MSC-exosomes improved the in vitro survival and function of neutrophils from patients with severe congenital neutropenia, thus increasing the potential efficacy of MSC-exosomes against acute infection [42]. Moreover, studies have suggested that MSC-exosomes exhibit effects in managing autoimmune or inflammatory diseases [37,43] (Table 1).…”

Section: Immunomodulationmentioning

confidence: 99%

Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

Gao

et al. 2020

Cells

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Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.

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Exosomes derived from mesenchymal stem cells improved function and survival of neutrophils from severe congenital neutropenia patients in vitro

Cited by 23 publications

References 22 publications

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

Potential Roles of Tumor Cell- and Stroma Cell-Derived Small Extracellular Vesicles in Promoting a Pro-Angiogenic Tumor Microenvironment

Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

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