Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p/TGFβR1 pathway

Wu, Junwei; Wang, Xinxin; Fu, Guoping; Feng, Yuandong; Wang, Yan; Zhang, Guoxian; Wu, Yingliang; Zhang, Lirong; Meng, Hongyu; Wen, Jianguo; Zhang, Bing; Wang, Qingwei

doi:10.1007/s11010-022-04484-3

Cited by 5 publications

(6 citation statements)

References 48 publications

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“…Additionally, Wu et al elucidated that exosomes derived from human USCs containing NRF1 could mitigate bladder fibrosis by modulating the miR-301b-3p/TGFβR1 pathway. Thoes discovery represents a novel therapeutic direction for the treatment of bladder outlet obstruction (BOO) [ 63 ].…”

Section: Protection Of Kidney Injurymentioning

confidence: 99%

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Sun,

Zhao,

Yang

et al. 2024

Heliyon

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Section: Protection Of Kidney Injurymentioning

confidence: 99%

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Sun,

Zhao,

Yang

et al. 2024

Heliyon

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“…USCs suppress Th1 and Th17 immune responses in rodent models of inflammatory bowel disease, which further demonstrates their capacity to reduce inflammation and prevent fibrosis [ 49 ]. Studies in recent years [ 48 , 69 , 70 ] have also shown the involvement of USCs and their paracrine compounds in reducing bladder, cardiac, penile and glomerular fibrosis, but these studies have not examined the roles of USCs in other types of tissue fibrosis. The immunomodulatory and antifibrotic properties of USCs may contribute to PF, but additional research is needed to confirm this hypothesis.…”

Section: Sources Of Stem Cells and New Treatmentsmentioning

confidence: 99%

Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics

Huang,

Xia,

et al. 2023

Stem Cell Res Ther

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Peritoneal fibrosis (PF) is a pathophysiological condition caused by a variety of pathogenic factors. The most important features of PF are mesothelial–mesenchymal transition and accumulation of activated (myo-)fibroblasts, which hinder effective treatment; thus, it is critical to identify other practical approaches. Recently, stem cell (SC) therapy has been indicated to be a potential strategy for this disease. Increasing evidence suggests that many kinds of SCs alleviate PF mainly by differentiating into mesothelial cells; secreting cytokines and extracellular vesicles; or modulating immune cells, particularly macrophages. However, there are relatively few articles summarizing research in this direction. In this review, we summarize the risk factors for PF and discuss the therapeutic roles of SCs from different sources. In addition, we outline effective approaches and potential mechanisms of SC therapy for PF. We hope that our review of articles in this area will provide further inspiration for research on the use of SCs in PF treatment.

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“…The therapeutic potential of UDSCs for neurological diseases remains relatively unexplored, yet the limited findings obtained thus far hold promise. UDSCs engraftment or their secretomes have shown to be effective mostly in preclinical reports of renal and bladder diseases, such as acute kidney injury ( Li X. et al, 2020 ), renal acute tubular injury ( Grange et al, 2020 ) or bladder fibrosis ( Wu et al, 2023 ), evidencing a consistent tissue ( Li F. et al, 2020 ; Li X. et al, 2020 ) regeneration effect, mainly through their pro-angiogenic, anti-apoptotic and anti-inflammatory effects ( Grange et al, 2020 ; Li F. et al, 2020 ; Li X. et al, 2020 Wu et al, 2023 ), over the living afflicted tissues. Within the field of neurological disorders, very few studies of UDSCs in vivo preclinical engraftment have been performed.…”

Section: Udscs-based Approaches To Brain Disease Therapymentioning

confidence: 99%

“…Similarly, to the therapeutic effects in the scope of direct UDSCs transplantation, preclinical studies employing UDSCs-derived secretome also show promising results for the treatment of brain disorders. UDSCs-related secretomes’ regenerative and immunomodulatory properties arose in several diseases, from urological ( Grange et al, 2020 ; Li X. et al, 2020 ; Wu et al, 2023 ) to diabetic wound healing ( Zhao et al, 2018 ). Several authors hypothesized that UDSCs therapeutic may depend on these cells’ ability to secrete various bioactive cargoes.…”

Section: Udscs-based Approaches To Brain Disease Therapymentioning

confidence: 99%

“…UDSCs-related secretomes' regenerative and immunomodulatory properties arose in several diseases, from urological (Grange et al, 2020;Wu et al, 2023) to diabetic wound healing (Zhao et al, 2018). Several authors hypothesized that UDSCs therapeutic may depend on these cells' ability to secrete various bioactive cargoes.…”

Section: Udscs Secretome-based Approaches To Brain Diseases Therapymentioning

confidence: 99%

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Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

Cavaleiro,

Afonso,

Oliveira

et al. 2023

Front. Mol. Neurosci.

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Stem cells have potential applications in the field of neurological diseases, as they allow for the development of new biological models. These models can improve our understanding of the underlying pathologies and facilitate the screening of new therapeutics in the context of precision medicine. Stem cells have also been applied in clinical tests to repair tissues and improve functional recovery. Nevertheless, although promising, commonly used stem cells display some limitations that curb the scope of their applications, such as the difficulty of obtention. In that regard, urine-derived cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, their obtaining can be challenging due to the low yield and complexity of the multi-phased and typically expensive differentiation protocols. As an alternative, urine-derived stem cells (UDSCs), included within the population of urine-derived cells, present a mesenchymal-like phenotype and have shown promising properties for similar purposes. Importantly, UDSCs have been differentiated into neuronal-like cells, auspicious for disease modeling, while overcoming some of the shortcomings presented by other stem cells for these purposes. Thus, this review assesses the current state and future perspectives regarding the potential of UDSCs in the ambit of neurological diseases, both for disease modeling and therapeutic applications.

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Exosomes from human urine-derived stem cells carry NRF1 to alleviate bladder fibrosis via regulating miR-301b-3p/TGFβR1 pathway

Cited by 5 publications

References 48 publications

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond

Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions

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