Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

Wang, Chen; Li, Zhelong; Liu, Yunnan; Yuan, Lijun

doi:10.7150/thno.56035

Cited by 110 publications

(65 citation statements)

References 219 publications

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“…Zheng et al found that vascular smooth muscle cellderived exosomes mediate the transfer of Krüppel-like factor 5induced miR-155 from smooth muscle cells to endothelial cells, damaging the tight junction of endothelial cells and the integrity of barriers leading to increased endothelial cell permeability and accelerating atherosclerosis (76). Macrophage-derived exosome miR-21-3p, which has been treated with nicotine, the principal component of cigarette smoke, may accelerate the development of atherosclerosis by increasing the migration and proliferation of vascular smooth muscle cells through its target protein (77). Exosomes mediate the occurrence and development of CVDs via upstream or downstream signaling pathways in vivo, and the relevant mechanisms are being elucidated (78)(79)(80).…”

Section: Function and Mechanism Of Exosomes In Cvdsmentioning

confidence: 99%

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Guan

Song

et al. 2021

Front. Cardiovasc. Med.

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Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research.Methods: The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software.Results: A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. Circulation Research was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study.Conclusion: We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.

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Section: Function and Mechanism Of Exosomes In Cvdsmentioning

confidence: 99%

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Guan

Song

et al. 2021

Front. Cardiovasc. Med.

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“…miRNA-133a, miRNA-143/145, miRNA-150, miRNA-155, miRNA-214, miRNA-223, and miRNA320b in exosomes are considered as markers of arthrosclerosis (AS) [ 131 , 132 ]. Several proteins are suggested as biomarkers of AS, including integrins derived from exosomes secreted via macrophage foam cell [ 133 ], PSMA6 (prostate-specific membrane antigen), PSMA7, and annexin A2 in blood exosomes originated from innate immune system cells [ 21 , 134 ] and VCAM-1 (vascular cell adhesion molecule 1) and eNOS (endothelial constitutive nitric oxide synthase) identified in plasma endothelial cell-derived exosome [ 131 , 135 ].…”

Section: Clinical Application Of Evsmentioning

confidence: 99%

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar

Malekian

Baghban

et al. 2022

Cells

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The use of extracellular vesicles (EV) in nano drug delivery has been demonstrated in many previous studies. In this study, we discuss the sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue. Extensive research in the past decade has established that the breadth of EV applications is wide. However, the efforts on standardizing the isolation and purification methods have not brought us to a point that can match the potential of extracellular vesicles for clinical use. The standardization can open doors for many researchers and clinicians alike to experiment with the proposed clinical uses with lesser concerns regarding untraceable side effects. It can make it easier to identify the mechanism of therapeutic benefits and to track the mechanism of any unforeseen effects observed.

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“…Ox-LDL induces monocytes/macrophages inflammatory response emerge as a key event in atherosclerosis. EVs released from macrophages stimulate pro-inflammatory responses by transporting miRNAs and lncRNAs into recipient cells (88). For example, M1-like-type macrophages secrete numerous pro-inflammatory EVs, with anti-angiogenic properties (45).…”

Section: Monocytes/macrophagesmentioning

confidence: 99%

“…As for diagnosis, miRNAs and lncRNAs in EVs have important advantages of serving as non-invasive biomarkers due to EVs are easily accessible and highly stabile in body fluids, such as blood, saliva, and urine (88). In addition, miRNAs and lncRNAs encapsulated in EVs exhibit better application compared with circulating miRNAs and lncRNAs, due to the high sensitivity and specificity of EVs (128).…”

Section: Mirnas and Lncrnas In Evs As Diagnostic Biomarkers In Atherosclerosismentioning

confidence: 99%

Mechanisms of Action of MiRNAs and LncRNAs in Extracellular Vesicle in Atherosclerosis

Liu

2021

Front. Cardiovasc. Med.

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Atherosclerosis, a complex chronic inflammatory disease, involves multiple alterations of diverse cells, including endothelial cells (ECs), vascular smooth muscle cells (VSMCs), monocytes, macrophages, dendritic cells (DCs), platelets, and even mesenchymal stem cells (MSCs). Globally, it is a common cause of morbidity as well as mortality. It leads to myocardial infarctions, stroke and disabling peripheral artery disease. Extracellular vesicles (EVs) are a heterogeneous group of cell-derived membranous structures that secreted by multiple cell types and play a central role in cell-to-cell communication by delivering various bioactive cargos, especially microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Emerging evidence demonstrated that miRNAs and lncRNAs in EVs are tightly associated with the initiation and development of atherosclerosis. In this review, we will outline and compile the cumulative roles of miRNAs and lncRNAs encapsulated in EVs derived from diverse cells in the progression of atherosclerosis. We also discuss intercellular communications via EVs. In addition, we focused on clinical applications and evaluation of miRNAs and lncRNAs in EVs as potential diagnostic biomarkers and therapeutic targets for atherosclerosis.

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Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets

Cited by 110 publications

References 219 publications

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Mechanisms of Action of MiRNAs and LncRNAs in Extracellular Vesicle in Atherosclerosis

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