Exosomes in subarachnoid hemorrhage: A scoping review

Bhimani, Abhiraj D.; Kalagara, Roshini; Chennareddy, Susmita; Kellner, Christopher P.

doi:10.1016/j.jocn.2022.08.025

Cited by 5 publications

(6 citation statements)

References 59 publications

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“…Neuroinflammation drives damage progression in IA and SAH. Because of its role in immune cell response regulation and inflammatory gene expression, miRNA could be a promising target for minimally invasive diagnostic and prophylactic purposes [ 22 ]. Tissue cells secrete miRNAs into the circulation and other biological fluids inside vesicles.…”

Section: Micrornamentioning

confidence: 99%

“…MiRNA changes can also affect the brain-derived neurotrophic factor (BDNF)/tyrosine kinase B (TrkB)/cAMP-response element-binding protein (CREB) (BDNF/TrkB/CREB) pathway [ 22 ]. In a rat SAH model, Zhao et al targeted BDNF with miR-206 delivered through exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) [ 50 ].…”

Section: Microrna-based Therapies For Sahmentioning

confidence: 99%

“…Bhimani et al discovered that miRNAs had both anti-inflammatory and anti-apoptotic effects, and that these effects were mediated through the CREB and PI3K/Akt/NF-κB pathways. They also suggested that delivering miRNAs through exosomes could be a potential treatment for vasospasm [ 22 ].…”

Section: Exosomesmentioning

confidence: 99%

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MicroRNAs’ Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

et al. 2023

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Subarachnoid hemorrhage (SAH) is most commonly seen in patients over 55 years of age and often results in a loss of many productive years. SAH has a high mortality rate, and survivors often suffer from early and secondary brain injuries. Understanding the pathophysiology of the SAH is crucial in identifying potential therapeutic agents. One promising target for the diagnosis and prognosis of SAH is circulating microRNAs, which regulate gene expression and are involved in various physiological and pathological processes. In this review, we discuss the potential of microRNAs as a target for diagnosis, treatment, and prognosis in SAH.

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Section: Micrornamentioning

confidence: 99%

Section: Microrna-based Therapies For Sahmentioning

confidence: 99%

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MicroRNAs’ Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

et al. 2023

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“… 16 They are involved in the immune response, 15 , 17 , 18 , 19 antigen presentation, cell migration, differentiation and angiogenesis, 20 , 21 inflammatory induction, 22 oxidative stress and apoptosis, 23 atherosclerosis, 24 , 25 tumor initiation, progression, invasion and metastasis, and drug resistance. 26 , 27 Given the ability of exosomes to carry and transfer bioactive substances, 28 the potential of exosomes to reveal the pathogenesis of diseases such as cancer, 29 , 30 , 31 , 32 , 33 brain diseases, 34 , 35 , 36 , 37 cardiovascular diseases, 38 , 39 , 40 , 41 , 42 , 43 , 44 and metabolic diseases, 45 , 46 , 47 as well as to diagnose and treat diseases as biomarkers are being studied and explored. 48 , 49 , 50 , 51 , 52 …”

Section: Introductionmentioning

confidence: 99%

“…16 They are involved in the immune response, 15,[17][18][19] antigen presentation, cell migration, differentiation and angiogenesis, 20,21 inflammatory induction, 22 oxidative stress and apoptosis, 23 atherosclerosis, 24,25 tumor initiation, progression, invasion and metastasis, and drug resistance. 26,27 Given the ability of exosomes to carry and transfer bioactive substances, 28 the potential of exosomes to reveal the pathogenesis of diseases such as cancer, [29][30][31][32][33] brain diseases, [34][35][36][37] cardiovascular diseases, [38][39][40][41][42][43][44] and metabolic diseases, [45][46][47] as well as to diagnose and treat diseases as biomarkers are being studied and explored. [48][49][50][51][52] The prevalence of neuropsychiatric disorders, the leading cause of disability in humans, has increased in the last few decades 53 and continues to grow due to the coronavirus disease (COVID-19) outbreak in 2019.…”

mentioning

confidence: 99%

Exosomes in brain diseases: Pathogenesis and therapeutic targets

Pang

et al. 2023

MedComm

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Exosomes are extracellular vesicles with diameters of about 100 nm that are naturally secreted by cells into body fluids. They are derived from endosomes and are wrapped in lipid membranes. Exosomes are involved in intracellular metabolism and intercellular communication. They contain nucleic acids, proteins, lipids, and metabolites from the cell microenvironment and cytoplasm. The contents of exosomes can reflect their cells’ origin and allow the observation of tissue changes and cell states under disease conditions. Naturally derived exosomes have specific biomolecules that act as the “fingerprint” of the parent cells, and the contents changed under pathological conditions can be used as biomarkers for disease diagnosis. Exosomes have low immunogenicity, are small in size, and can cross the blood–brain barrier. These characteristics make exosomes unique as engineering carriers. They can incorporate therapeutic drugs and achieve targeted drug delivery. Exosomes as carriers for targeted disease therapy are still in their infancy, but exosome engineering provides a new perspective for cell‐free disease therapy. This review discussed exosomes and their relationship with the occurrence and treatment of some neuropsychiatric diseases. In addition, future applications of exosomes in the diagnosis and treatment of neuropsychiatric disorders were evaluated in this review.

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MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

Segherlou¹,

Saldarriga²,

Azizi³

et al. 2023

Preprint

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Subarachnoid hemorrhage (SAH) is most commonly seen in patients over 55 years of age and often results in a loss of many productive years. SAH has a high mortality rate, and sur-vivors often suffer from early and secondary brain injuries. Understanding the pathophysiology of the SAH is crucial to identifying potential therapeutic agents. One promising target for diagno-sis and prognosis of SAH is circulating microRNAs, which regulate gene expression and are in-volved in various physiological and pathological processes. In this review, we discuss the poten-tial of microRNAs as a target for diagnosis, treatment, and prognosis in SAH.

show abstract

Exosomes in subarachnoid hemorrhage: A scoping review

Cited by 5 publications

References 59 publications

MicroRNAs’ Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

MicroRNAs’ Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

Exosomes in brain diseases: Pathogenesis and therapeutic targets

MicroRNAs Role in Diagnosis and Treatment of Subarachnoid Hemorrhage

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