Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor si<scp>RNA</scp>

Zhang, Haiyang; Wang, Yi; Bai, Ming; Wang, Junyi; Zhu, Kegan; Li, Rui; Ge, Shaohua; Li, Jia Lu; Ning, Tao; Deng, Ting; Fan, Qian; Liu, Hongli; Sun, Wei; Ying, Guoguang; Ba, Yi

doi:10.1111/cas.13488

Cited by 125 publications

(87 citation statements)

References 41 publications

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“…The secreted EVs display a potent gene knockdown, when internalized in cancer cell, due to the presence of the anti-miR-21 [155]. EVs overexpressing hepatocyte growth factor (HGF) siRNA drastically reduced HGF and vascular endothelial growth factor (VEGF) expression in gastric cancer [172]. EVs delivery of siRNA against RAD51 and RAD52 causes an inhibition of proliferation and a massive reproductive cell death in human breast cancer cells [173].…”

Section: Indirect Loadingmentioning

confidence: 99%

“…Inhibit schwannoma tumor growth [171] Exosomes from HEK 293T HGF siRNA Inhibition of tumor growth and angiogenesis in gastric cancer [172] Exosomes from breast cancer cells RAD51 and RAD52 siRNA Gene therapy against breast cancer [173] Extracellular vesicles from mesenchymal stem cells TNF-related apoptosis-inducing ligand (TRAIL)…”

Section: Evs Type Nanotechnological Modification Application Referencementioning

confidence: 99%

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Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Susa

Limongi

Dumontel

et al. 2019

Cancers

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Fast diagnosis and more efficient therapies for cancer surely represent one of the huge tasks for the worldwide researchers’ and clinicians’ community. In the last two decades, our understanding of the biology and molecular pathology of cancer mechanisms, coupled with the continuous development of the material science and technological compounds, have successfully improved nanomedicine applications in oncology. This review argues on nanomedicine application of engineered extracellular vesicles (EVs) in oncology. All the most innovative processes of EVs engineering are discussed together with the related degree of applicability for each one of them in cancer nanomedicines.

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Section: Indirect Loadingmentioning

confidence: 99%

Section: Evs Type Nanotechnological Modification Application Referencementioning

confidence: 99%

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Susa

Limongi

Dumontel

et al. 2019

Cancers

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“…Because of the low stability of siRNA, exosome‐based delivery is favorable. The pathologic function and therapeutic potential of several exosomal miRNA and siRNA in cancer have been evaluated in vitro and in vivo . These therapeutic agents can influence on cellular functions by silencing target genes, such as the cyclin‐dependent kinase 2 (CDK2) implicated in the regulation of cell cycle, the transcription factor E2F2, and the Sp1 transcription factor (SP1) involved in the regulation of cell proliferation, apoptosis, migration and invasion in cancer, and the antiapoptotic protein .…”

Section: Therapeutic Role Of Exosomes In Cancermentioning

confidence: 99%

“…The pathologic function and therapeutic potential of several exosomal miRNA and siRNA in cancer have been evaluated in vitro and in vivo. 24,190,191 These therapeutic agents can influence on cellular functions by silencing target genes, such as the cyclin-dependent kinase 2 (CDK2) implicated in the regulation of cell cycle, the transcription factor E2F2, and the Sp1 transcription factor (SP1) involved in the regulation of cell proliferation, apoptosis, migration and invasion in cancer, and the antiapoptotic protein. 36 For example, apoptosis of the HepG2 hepatocellular carcinoma cell lines by plasma-derived exosomes loaded with antitumor miRNAs (miR-31 and miR-451a) has been successfully promoted.…”

Section: Exosomal Mirnas Circrnas and Lncrnas In Cancer Therapymentioning

confidence: 99%

Exosomes and cancer: From oncogenic roles to therapeutic applications

et al. 2019

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Exosomes belong to extracellular vehicles that were produced and secreted from most eukaryotic cells and are involved in cell‐to‐cell communications. They are an effective delivery system for biological compounds such as mRNAs, microRNAs (miRNAs), proteins, lipids, saccharides, and other physiological compounds to target cells. In this way, they could influence on cellular pathways and mediate their physiological behaviors including cell proliferation, tumorigenesis, differentiation, and so on. Many research studies focused on their role in cancers and also on potentially therapeutic and biomarker applications. In the current study, we reviewed the exosomes' effects on cancer progression based on their cargoes including miRNAs, long noncoding RNAs, circular RNAs, DNAs, mRNAs, proteins, and lipids. Moreover, their therapeutic roles in cancer were considered. In this regard, we have given a brief overview of challenges and obstacles in using exosomes as therapeutic agents.

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“…For example, engineered exosomes loaded with doxorubicin can be safely delivered to the tumor microenvironment, demonstrating similar tumor growth inhibition with less adverse effects compared with equipotent free drug (56)(57)(58) (60) demonstrated that exosomes loaded with HGF siRNA could inhibit tumor growth and angiogenesis in gastric cancer. It is hoped that an exosome-based approach for the treatment of gastric cancer with or without peritoneal dissemination will be developed in the near future.…”

Section: Chemoresistance and Exosome-based Treatment Of Peritoneal DImentioning

confidence: 99%

Exosome‑mediated peritoneal dissemination in gastric cancer and its clinical applications (Review)

Chen

Jin

et al. 2018

biom rep

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Abstract. The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance. The present review focuses on previous studies addressing the exosome-dependent molecular transfer in peritoneal dissemination in gastric cancer and the potential clinical applications. Contents1. Introduction 2. Exosomes in peritoneal dissemination of gastric cancer 3. Early detection by exosomal miRNAs 4. Chemoresistance and exosome-based treatment of peritoneal dissemination cases of gastric cancer IntroductionPeritoneal dissemination is detected in 14% of patients with gastric cancer at the time of initial diagnosis, for whom the median survival time is 4 months (1). Gastric cancer patients with peritoneal dissemination cannot undergo radical surgery, and the chemotherapeutic effect is limited due to inadequate distribution of intravenous chemotherapy drugs, blocked by the peritoneal barrier, and tumor chemoresistance (2). The 5-year survival rate of gastric cancer patients with peritoneal dissemination is only 2% (3). Peritoneal dissemination is among the most common patterns of recurrence in gastric cancer patients (4). However, it remains unclear how peritoneal dissemination exactly occurs, and there is a need to reveal the underlying molecular mechanism, as well as to develop more effective treatment strategies. Exosomes are macromolecular, phospholipid bilayer vesicles comprised of proteins, nucleic acids and lipids (5). At 40-120 nm in diameter, exosomes are smaller than other vesicles including microvesicles (100 nm-1 µm) and apoptotic bodies (50 nm-2 µm) (6). Exosomes exist in all body fluids and are generated by secretion and budding from various types of cells, including tumor cells (7). They contain key biological molecules including proteins, RNAs and lipids, which are considered to mediate intercellular communication (6). In particular, exosomes deliver proteins and RNAs associated with different pathologies, including neurodegenerative diseases, HIV infection, heart disease and tumor progression, from host cells to recipient cells (8). Tumor-derived exosomes (TEX) may have the capacity to remodel the tumor microenvironment to make it favorable for metastatic niches (7) and, furthermore, may alter the extracellular matrix and attract more cancer cells to the niches (9). Notably, increasing studies indicate that exosomes are involved in the peritoneal dissemination of gastric cancer. The present review focuses on how exos...

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Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA

Cited by 125 publications

References 41 publications

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

Exosomes and cancer: From oncogenic roles to therapeutic applications

Exosome‑mediated peritoneal dissemination in gastric cancer and its clinical applications (Review)

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