Expanded polytetrafluoroethylene arterial prostheses in humans: chemical analysis of 79 explanted specimens

Guidoin, Robert; Maurel, Sophie; Chakfé, Nabil; How, T.V.; Zhang, Ze; Themen, Marie; Formichi, Maxime; Gosselin, C.

doi:10.1016/0142-9612(93)90068-d

Cited by 36 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They were mainly standard wall, with four being thin wall, three tapered and three externally supported. The microstructure of all the prostheses was a microporous one, composed of several fibrils linking nodules [28]. The internal diameter was 6 mm for 66 prostheses, 8 mm for 28, 12 mm for one, and for the remaining nine prostheses it was not indicated and could not be determined.…”

Section: The Prosthesesmentioning

confidence: 99%

Lipid uptake in ePTFE arterial prostheses implanted in humans

Bédard

Marois

Guidoin

et al. 1996

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Lipid uptake in 104 ePTFE microporous vascular prostheses implanted in humans was investigated using Fourier transform infrared (FTIR) spectroscopy. The assignment of the infrared features observed in the spectra of explanted ePTFE microporous vascular prostheses shows unambiguously the presence of fatty acids in the structure of the arterial prosthesis wall. In addition, higher lipid concentration is found on the external side of the prostheses before 500 days of implantation, after which this behaviour is reversed. Finally, it seems that a greater amount of lipids are present on the surfaces of prostheses implanted in extra-anatomical sites as compared to those implanted in anatomical sites.

show abstract

Section: The Prosthesesmentioning

confidence: 99%

Lipid uptake in ePTFE arterial prostheses implanted in humans

Bédard

Marois

Guidoin

et al. 1996

J Mater Sci: Mater Med

View full text Add to dashboard Cite

show abstract

“…4 Small-diameter vascular vessel systems are particularly important in bypass surgery and vascular-reconstruction procedures. 8,9 The use of ePTFE for clinical coronary bypass applications is currently avoided owing to low patency. 7 However, FTIR analysis has revealed significant protein interactions and, in particular, lipid uptake that correlates with implantation time and patient-related risk factors.…”

Section: Introductionmentioning

confidence: 99%

Mass spectrometric imaging of in vivo protein and lipid adsorption on biodegradable vascular replacement systems

Fröhlich

Eilenberg

Svirkova

et al. 2015

Analyst

View full text Add to dashboard Cite

Cardiovascular diseases present amongst the highest mortality risks in Western civilization and are frequently caused by arteriosclerotic vessel failure. Coronary artery and peripheral vessel reconstruction necessitates the use of small diameter systems that are mechanically stress-resistant and biocompatible. Expanded polytetrafluorethylene (ePTFE) is amongst the materials used most frequently for non-degradable and bio-degradable vessel reconstruction procedures, with thermoplastic polyurethanes (TPU) representing a promising substitute. The present study describes and compares the biological adsorption and diffusion occurring with both materials following implantation in rat models. Gel electrophoresis and thin-layer chromatography, combined with mass spectrometry and mass spectrometry imaging, were utilized to identify the adsorbed lipids and proteins. The results were compared with the analytes present in native aorta tissue. It was revealed that both polymers were severely affected by biological adsorption after 10 min in vivo. Proteins associated with cell growth and migration were identified, especially on the luminal graft surface, while lipids were found to be located on both the luminal and abluminal surfaces. Lipid adsorption and cholesterol diffusion were found to be correlated with the polymer modifications identified on degradable thermoplastic urethane graft samples, with the latter revealing extensive cholesterol adsorption. The present study demonstrates an interaction between biological matter and both graft materials, and provides insights into polymer changes, in particular, those observed with thermoplastic urethanes already after 10 min in vivo exposure. ePTFE demonstrated minor polymer modifications, whereas several different polymer signals were observed for TPU, all were co-localized with biological signals.

show abstract

“…The ePTFE has been believed to be an inert material for vascular prosthesis, it cannot be degraded in vivo [16]. The nonsticky characteristic of the ePTFE provide a relatively nonthrombogenic surface for the graft [17].…”

Section: Carotid Resection and Reconstructionmentioning

confidence: 99%

Treatment of recurrent head and neck carcinoma involving the carotid artery: carotid reconstruction with ePTFE graft

Chen

Shu

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The aim of our study is to investigate the feasibility of reconstructing the carotid artery using expanded polytetraflouroethylene (ePTFE) in patients with recurrent head and neck carcinoma involving the carotid artery. Ten patients, who had recurrent head and neck carcinoma involving the carotid artery, received carotid artery resection and reconstruction with ePTFE, tissue defects were repaired by pectoralis major myocutaneous flap. Results show that eight patients did not present any vascular and neurologic complications. One patient presented slight hemiparesis, another patient developed wound infection and pharyngocutaneous fistula. The mean follow-up period was 33.1 ± 16.0 months. The 2-year survival rate was 50% (5/10), and there was one patient who survived for 60 months without locoreginal recurrence or distant metastasis. En bloc resection of tumor and involved carotid-associated ePTFE reconstruction provide effective improvement in the locoregional control of the recurrent head and neck carcinoma. The pedicle pectoralis major myocutaneous flap can provide not only wound bed with affluent blood supply for the vascular grafts, but also reparation of skin or the tissue defects of oropharynx and hypopharynx.

show abstract

Expanded polytetrafluoroethylene arterial prostheses in humans: chemical analysis of 79 explanted specimens

Cited by 36 publications

References 23 publications

Lipid uptake in ePTFE arterial prostheses implanted in humans

Lipid uptake in ePTFE arterial prostheses implanted in humans

Mass spectrometric imaging of in vivo protein and lipid adsorption on biodegradable vascular replacement systems

Treatment of recurrent head and neck carcinoma involving the carotid artery: carotid reconstruction with ePTFE graft

Contact Info

Product

Resources

About