2024
DOI: 10.1101/2024.12.02.626298
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Expanding the CarD interaction network: CrsL is a novel transcription factor inMycobacterium smegmatis

Mahmoud Shoman,
Jitka Jirát Matějčková,
Marek Schwarz
et al.

Abstract: Bacterial transcription regulation is critical for adaptation and survival. CarD is an essential transcription factor in mycobacteria involved in regulation of gene expression. We searched for CarD interaction partners in the model organism Mycobacterium smegmatis and identified two proteins: ApeB (MSMEG_5828) and an uncharacterized protein, which we named CrsL (MSMEG_5890). While ApeB interacted with CarD only when CarD was overexpressed, CrsL associated with CarD at its physiological levels. CrsL is a 5.7 kD… Show more

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