Expanding the Foundation for Personalized Medicine

García, Isabel; Kuska, Robert; Somerman, Martha J.

doi:10.1177/0022034513487209

Cited by 48 publications

(4 citation statements)

References 52 publications

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“…To provide effective oral healthcare, certain improvements are needed in validating its routine. Moreover, certain scientific and technological gaps are to be considered, including linkages between clinical outcomes, genotypes, and individual biomarkers, cost-effectiveness, and improved drug design and delivery using artificial intelligence [ 151 ]. There is a need for further research in this particular field to develop tools for patient-specific precision healthcare.…”

Section: Ethical Considerations and Future Research Directionsmentioning

confidence: 99%

A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health

et al. 2023

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Artificial intelligence has made substantial progress in medicine. Automated dental imaging interpretation is one of the most prolific areas of research using AI. X-ray and infrared imaging systems have enabled dental clinicians to identify dental diseases since the 1950s. However, the manual process of dental disease assessment is tedious and error-prone when diagnosed by inexperienced dentists. Thus, researchers have employed different advanced computer vision techniques, and machine- and deep-learning models for dental disease diagnoses using X-ray and near-infrared imagery. Despite the notable development of AI in dentistry, certain factors affect the performance of the proposed approaches, including limited data availability, imbalanced classes, and lack of transparency and interpretability. Hence, it is of utmost importance for the research community to formulate suitable approaches, considering the existing challenges and leveraging findings from the existing studies. Based on an extensive literature review, this survey provides a brief overview of X-ray and near-infrared imaging systems. Additionally, a comprehensive insight into challenges faced by researchers in the dental domain has been brought forth in this survey. The article further offers an amalgamative assessment of both performances and methods evaluated on public benchmarks and concludes with ethical considerations and future research avenues.

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Section: Ethical Considerations and Future Research Directionsmentioning

confidence: 99%

A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health

et al. 2023

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“…[87][88][89][90] The future of integrated oral and primary care healthcare will continue to evolve, increasing the focus on prevention, deploying tools to enhance precision and personalized care, incorporating new technologies such as telemedicine and smartphone communications, and facilitating easier access to care. 72,[112][113][114][115][116][117][118][119][120][121][122][123][124] Oral healthcare integrated into primary care with teams consisting of health professionals with expertise in pediatrics, geriatrics, internal medicine, oral health and disease, family medicine, primary care, nursing, behavioral sciences, and social service will increasingly provide healthy and brighter smiles. 1,2,28,[69][70][71][72][73][74][75][76][77]…”

Section: Reducing Oral Disease Risks and Enhancing Healthmentioning

confidence: 99%

Science-Informed Health Policies for Oral and Systemic Health

Slavkin¹,

DuBois²,

Kleinman³

et al. 2023

JHL

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Oral, dental and craniofacial (ODC) health has a profound impact on general health and welfare throughout life, yet US dentists and physicians operate across misaligned silos. This protracted division limits access to optimal health, supports fee for services, and exacerbates health disparities. Early in the 20th century, the most frequent dental therapy was tooth extraction: removed infected teeth were substituted by prosthetic appliances – commonly, dentures or nothing. Most adults assumed becoming edentulous was a normal corollary of aging. With the discovery of penicillin and other antibiotics, healthcare professionals and policy makers predicted infectious diseases would become irrelevant. However, given numerous health threats, including SARS-CoV-2, HIV, multidrug-resistant bacteria, Zika virus, Ebola virus, and now monkeypox, public and professional awareness of transmissible infectious diseases has never been more evident. Ironically, little attention has been paid to unmet transmissible, infectious, common oral diseases – dental caries and periodontal diseases. Therefore, these persist within “the silent and invisible epidemic”. The preventable death of a young boy in 2007 from an infected untreated tooth that produced bacterial meningitis is a profound reminder that our nation has vast inequities in education, health, and welfare. The impact of oral infections on hospital-acquired pneumonia, post-operative infection in cardiac valve surgery, and even academic performances of disadvantaged children displayed through sociodemographic characteristics and access to care determinants also are profound! This paper asserts that current and emerging ODC health knowledge and science will inform health policies and advance equity in access to care, affordable costs, and optimal healthcare outcomes. We recommend that legal and regulatory systems and public health programs be required to ensure health equity. A fair healthcare system that addresses holistic healthcare must be transparent, accessible, integrated and provide a standard of oral healthcare based upon scientific evidence for all people across the lifespan.

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“…Overall, personalized medicine holds the key to unlocking a new frontier in dental research. Genomic sequencing, combined with the developments in medical imaging and regenerative technology, has redefined personalized medicine using novel molecular tools to perform patient-specific precision healthcare [36,37]. It has the potential to revolutionize healthcare using genomics information for individual biomarker identification [38].…”

Section: Personalized (Dental) Medicinementioning

confidence: 99%

Recent Trends and Future Direction of Dental Research in the Digital Era

Joda

Bornstein

Jung

et al. 2020

IJERPH

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The digital transformation in dental medicine, based on electronic health data information, is recognized as one of the major game-changers of the 21st century to tackle present and upcoming challenges in dental and oral healthcare. This opinion letter focuses on the estimated top five trends and innovations of this new digital era, with potential to decisively influence the direction of dental research: (1) rapid prototyping (RP), (2) augmented and virtual reality (AR/VR), (3) artificial intelligence (AI) and machine learning (ML), (4) personalized (dental) medicine, and (5) tele-healthcare. Digital dentistry requires managing expectations pragmatically and ensuring transparency for all stakeholders: patients, healthcare providers, university and research institutions, the medtech industry, insurance, public media, and state policy. It should not be claimed or implied that digital smart data technologies will replace humans providing dental expertise and the capacity for patient empathy. The dental team that controls digital applications remains the key and will continue to play the central role in treating patients. In this context, the latest trend word is created: augmented intelligence, e.g., the meaningful combination of digital applications paired with human qualities and abilities in order to achieve improved dental and oral healthcare, ensuring quality of life.

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Expanding the Foundation for Personalized Medicine

Cited by 48 publications

References 52 publications

A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health

A Comprehensive Review of Recent Advances in Artificial Intelligence for Dentistry E-Health

Science-Informed Health Policies for Oral and Systemic Health

Recent Trends and Future Direction of Dental Research in the Digital Era

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