Expanding the Pancreas Donor Pool

Fridell, Jonathan A.; Stratta, Robert J.

doi:10.1007/s40472-014-0015-8

Cited by 12 publications

(9 citation statements)

References 76 publications

(104 reference statements)

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“…Surprisingly, many human pancreata are discarded after recovery from cadaveric donors, which represents a lost precious resource. Presently in the US, only ~17% of donor pancreata are recovered for transplantation 30 – 32 and ~25% of those recovered with intent to transplant are discarded 32 . While there are multiple reasons for not recovering pancreata or not transplanting after recovery, numerous organs are available for research through organ procurement organisations.…”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Sackett

Tremmel

et al. 2018

Sci Rep

224

164

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Extracellular matrix (ECM) plays an important developmental role by regulating cell behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained through decellularization, has been proposed in several strategies for tissue and organ replacement. Decellularization of animal pancreata has been reported, but the same methods applied to human pancreas are less effective due to higher lipid content. Moreover, ECM-derived hydrogels can be obtained from many decellularized tissues, but methods have not been reported to obtain human pancreas-derived hydrogel. Using novel decellularization methods with human pancreas we produced an acellular, 3D biological scaffold (hP-ECM) and hydrogel (hP-HG) amenable to tissue culture, transplantation and proteomic applications. The inclusion of a homogenization step in the decellularization protocol significantly improved lipid removal and gelation capability of the resulting ECM, which was capable of gelation at 37 °C in vitro and in vivo, and is cytocompatible with a variety of cell types and islet-like tissues in vitro. Overall, this study demonstrates the characterisation of a novel protocol for the decellularization and delipidization of human pancreatic tissue for the production of acellular ECM and ECM hydrogel suitable for cell culture and transplantation applications. We also report a list of 120 proteins present within the human pancreatic matrisome.

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Section: Introductionmentioning

confidence: 99%

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Sackett

Tremmel

et al. 2018

Sci Rep

224

164

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“…The pancreas discard rate remains the highest amongst all abdominal solid organs [5, 18,19]. Despite significant improvement in the outcomes of all types of pancreas transplantation (SPK, PTA, Pancreas After Kidney) [20], the number of pancreas transplants have decreased dramatically in recent years.…”

Section: Discussionmentioning

confidence: 99%

Pancreas utilization rates in the UK – an 11‐year analysis

Cornateanu

O’Neill

Dholakia³

et al. 2021

Transpl Int

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Utilization of pancreases for transplantation remains inferior to that of other organs. Herein, we analysed UK pancreas discards to identify the reasons for the low utilization rates. Data on all pancreases offered first for solid organ transplantation between 1st January 2005 and 31st December 2015 were extracted from the UK Transplant Registry. The number of organs discarded, reasons and the time point of discard were analysed. A centre specific comparison was also undertaken. 7367 pancreases were offered first for solid organ transplantation. 35% were donors after circulatory death (DCD). 3668 (49.7%) organs were not retrieved. Of the 3699 pancreases retrieved, 38% were initially accepted but subsequently discarded. 2145 (29%) grafts offered were transplanted as simultaneous pancreas-kidney or solitary pancreas. 1177 (55%) were transplanted on the first offer whilst the remaining 968 were transplanted after a median of three offers. 52% DBD pancreases were accepted and transplanted on the first offer compared with 68% DCD grafts. There were significant differences in discard rates between centres (30-80% for DBD and 3-78% for DCD, P < 0.001). A significant number of solid pancreases are discarded. Better graft assessment at retrieval could minimize unnecessary organ travel and discards. Closer links with islet programmes may allow for better utilization of discarded grafts.

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“…Apart from the overall shortage of cadaveric donor pancreata, the quality of a donor pancreas also plays an important role in determining transplant outcomes, with factors such as donor age and BMI, cause of death, duration of hospital stay, organ procurement team and cold ischemia time acting as major contributors [97][98][99][100][101][102]. Currently, the islet transplantation procedure is hindered by the quality of pancreas allocated.…”

Section: Shortage Of Donor Pancreatamentioning

confidence: 99%

Untitled

2020

OBM Transplantation

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Pulmonary transplantation (LuTx) is established as a treatment option for patients with endstage lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, and pulmonary arterial hypertension. Acute rejection and infection are implicated as potential risk factors in developing complications such as bronchiolitis obliterans syndrome (BOS) and chronic rejection, leading to high morbidity and mortality rates after the LuTx. Thus, surveillance procedures after transplantation are crucial to prevent further complications. Clinical monitoring is done through pulmonary function tests and procedural methods such as surveillance bronchoscopy and transbronchial biopsy of lung allografts, which are the most commonly used diagnostic tests. In this review, we aim to analyze the role of bronchoscopy as a surveillance procedure in determining the presence of infection or rejection as well as the management of airway complications after LuTx. We have also discussed the risk and benefit ratio of standard transbronchial biopsy (TBB) and transbronchial cryobiopsy (TCB) as routine performance after LuTx.

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Expanding the Pancreas Donor Pool

Cited by 12 publications

References 76 publications

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas

Pancreas utilization rates in the UK – an 11‐year analysis

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