2015
DOI: 10.1016/j.chroma.2015.01.042
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Expanding the potential of chiral chromatography for high-throughput screening of large compound libraries by means of sub–2μm Whelk-O 1 stationary phase in supercritical fluid conditions

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Cited by 49 publications
(32 citation statements)
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“…The renewed interest in the SFC analytical field concurs with the introduction of third‐generation SFC instruments (around 2010) able to be used with commercial UHPLC packed columns (sub‐2 μm FPP or sub‐3 μm SPP) . While a pioneering sub‐minute chiral SFC separation was reported as early as in 1993 , only in the last years several groups have developed widely accessible SFC methods based on UHPLC CSPs leading to highly efficient separations of enantiomers in the second time scale . Hamman et al.…”
Section: Enantioselective Ultra‐high‐performance Sfcmentioning
confidence: 99%
“…The renewed interest in the SFC analytical field concurs with the introduction of third‐generation SFC instruments (around 2010) able to be used with commercial UHPLC packed columns (sub‐2 μm FPP or sub‐3 μm SPP) . While a pioneering sub‐minute chiral SFC separation was reported as early as in 1993 , only in the last years several groups have developed widely accessible SFC methods based on UHPLC CSPs leading to highly efficient separations of enantiomers in the second time scale . Hamman et al.…”
Section: Enantioselective Ultra‐high‐performance Sfcmentioning
confidence: 99%
“…The trend toward smaller particles of silica support is also appearing now for chiral stationary phases, but it is not yet as prominent as in the achiral field. Unlike bonded‐silica stationary phases, the difficulty to produce polysaccharide phases with small particles is a key point, explaining why the first sub‐2 μm particle CSP described was not a polymer but a brush‐type phase . Commercially available polysaccharide CSP currently remain limited to 2.5 μm (Waters Trefoil stationary phases) or 3 μm (Daicel, Phenomenex, Regis Technologies, Dr. Maisch, YMC, and Kromasil).…”
Section: Chromatographic Conditions For Sfc Analysis Of Drug Moleculesmentioning
confidence: 99%
“…Commercially available polysaccharide CSP currently remain limited to 2.5 μm (Waters Trefoil stationary phases) or 3 μm (Daicel, Phenomenex, Regis Technologies, Dr. Maisch, YMC, and Kromasil). However, here again the benefits of improved efficiency to achieve improved enantioresolution will certainly prompt further developments in this field in the near future.…”
Section: Chromatographic Conditions For Sfc Analysis Of Drug Moleculesmentioning
confidence: 99%
“…More recently the revival of SFC has spilled over to the analytical area driven by strong advances in instrumentation [3,4]. The relatively low viscosity of the mobile phase in SFC as compared to LC makes SFC a prime candidate to boost the high throughput trend [5] and leading instrument manufacturers have apparently already embarked on this road.…”
Section: Introductionmentioning
confidence: 99%