Expectations of assisted conception for infertility

Hull, Mgr; Eddowes, H. A.; Fahy, Una; Abuzeid, M.; Mills, Sean R.; Cahill, DJ; Fleming, CF; Pg, Wardle; Ford, W. C. L.; McDermott, Alan

doi:10.1016/0020-7292(93)90786-v

Cited by 23 publications

(32 citation statements)

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“…Earlier results were previously reported [23]. The results in 1990-1992 using uFSH have also been reported in detail [1] and will therefore be only summar ised and updated here, along with our results in 1994 using only uFSH-HP.…”

Section: Clinical Studiessupporting

confidence: 51%

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Experience Using Preparations of Follicle-Stimulating Hormone Alone to Stimulate the Ovaries for Assisted Conception after Pituitary Desensitisation and Simplified Management of Treatment

Hull¹,

Joels²,

Prosser³

et al. 1995

Horm Res

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The results are reported of 2,204 cycles of treatment started for in vitro fertilisation and embryo transfer or gamete intrafallopian transfer, during 5 years, 1990-1994, using only follicle-stimulating hormone (FSH) preparations to stimulate the ovaries following pituitary desensitisation, combined with greatly simplified scheduling and monitoring of treatment. The physiological principles underlying these choices are discussed. In all women under 40 years of age and men with normal sperm, the use of unpurified urinary FSH in 1990-1993 resulted in oocyte collection in 94% of cycles started, pregnancy in 29% and live births in 23%. Using highly purified urinary FSH (uFSH-HP; Metrodin HP®) during 1994, the rate for oocyte collection was 97% and pregnancy 25% (birth rates not yet available). The difference compared with previous years was not significant. A study of 93 first cycles using uFSH-HP showed that the dosage required was usually (expressed as medians) 24 ampoules over 12 days (2 ampoules/day) resulting in 9 oocytes (range 2-36) of which 93% were mature and 64% resulted in cleaving embryos. The results are comparable with the best using human menopausal gonadotropin or unpurified FSH and classical detailed monitoring.

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Section: Clinical Studiessupporting

confidence: 51%

“…The IVF-ET and GIFT techniques have been described previous ly [1,23]. In brief, Ham's F10 medium was used forfollicle flushing, supplemented with patient's serum for embryo culture (15%) and embryo transfer (75%) which was done after 2 days.…”

Section: Ivf-et and Gift Methodsmentioning

confidence: 99%

Experience Using Preparations of Follicle-Stimulating Hormone Alone to Stimulate the Ovaries for Assisted Conception after Pituitary Desensitisation and Simplified Management of Treatment

Hull¹,

Joels²,

Prosser³

et al. 1995

Horm Res

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“…With the aim of being able to advise couples seeking IVF treatment, many studies have addressed cumulative pregnancy or live-birth rates per cycle (4)(5)(6)(7)(8)(9)(10)(11)(12), but to date only one has reported cumulative rates, including multiple pregnancies, in a sufficiently large cohort of couples from which to draw valid conclusions (12). According to that recent study, it is estimated that couples undergoing IVF have a 72% probability of live birth after six cycles of controlled ovarian stimulation (COS) and ovum pick-up (12).…”

mentioning

confidence: 99%

Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success

Garrido

Bellver

Remohı́

et al. 2011

Fertility and Sterility

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“…Therefore, 15 studies were finally selected to contribute to the analysis. Table 1 summarizes the key information extracted from these studies [49,[53][54][55][56][57][58][59][60][61][62][63][64][65][66]. The vast majority of the intrauterine insemination cycles were combined with mild to moderate ovarian stimulation by the use of exogenous gonadotropins and/or oral clomiphene citrate and/or sequential clomiphene citrate/gonadotropins.…”

Section: Pregnancy Rates For Women Over 40 Years In Iui/stim Treatmentmentioning

confidence: 99%

Female Age in ART: When to Stop?

Broekmans¹,

Klinkert²

2004

Gynecol Obstet Invest

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With increasing age the probability of ongoing pregnancy established by the use of assisted reproduction technology (ART) decreases. As a result the question arises whether age limits for the application of ART should be established. From a literature review and ongoing research data it appears that the costs per child born greatly increase after the age of 40 for both intrauterine insemination with mild ovarian stimulation and in vitro fertilisation treatment, while in cases of 44 and over, prognosis is flat zero. The willingness to pay for extra costs will greatly determine whether and at what age strict limits should be applied. Fortunately, predictive factors for success, like the antral follicle count, may enable the identification of women over 40 and under 44 that still have favourable prospects, thereby decreasing the necessary costs per childbirth and allowing couples into ART programs that are often denied based solely on female age.

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Expectations of assisted conception for infertility

Cited by 23 publications

References 0 publications

Experience Using Preparations of Follicle-Stimulating Hormone Alone to Stimulate the Ovaries for Assisted Conception after Pituitary Desensitisation and Simplified Management of Treatment

Experience Using Preparations of Follicle-Stimulating Hormone Alone to Stimulate the Ovaries for Assisted Conception after Pituitary Desensitisation and Simplified Management of Treatment

Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to measuring the likelihood of IVF success

Female Age in ART: When to Stop?

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