Expected developments in hepatology

The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell origin

“…Hepatocellular carcinoma (HCC) is a neoplasm that is increasing in incidence world‐wide 1 . HCC is the fifth most prevalent human tumour, the third cause of cancer‐related death globally and a major indication for liver transplantation 2 .…”

“…HCC is the fifth most prevalent human tumour, the third cause of cancer‐related death globally and a major indication for liver transplantation 2 . HCC thus constitutes a major health problem and its relevance is expected to increase in the near future 1 …”

Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours

“…HCC is a neoplasm of increasing incidence worldwide and is the fifth leading cause of death on a worldwide basis in man [3,4]. Although remarkable advances in surgical and imaging modalities have improved the prognosis of HCC patients [5], the high incidence of intrahepatic recurrence remains a major challenge in HCC therapy [6,7].…”

Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients

“…Elevated incidences of cytomegalovirus and posttransplant lymphoproliferative disease after use of biologic agents for the treatment of acute cellular rejection dampened enthusiasm for using these agents in induction protocols. The success with RATG in liver transplantation is tempered by the fact that increases in immunosuppression are associated with clinically significant hepatitis C (HCV) recurrence posttransplant, which occurs in 50% of patients by 1 year 8, 9…”