Experience in using minoxidil product line for the treatment of stress-induced non scarring alopecia

Abstract

Introduction. Sustained stress can promote the secretion of proinflammatory cytokines, such as INF-ɣ, which leads to inflammation and results in apoptosis, cell senescence, and disruption of hair growth cycles. It is important to know that a somatic disease itself can become a stress factor. In our case it is a hair loss, which provokes a reactive anxiety-depressive state (nosogenic reaction), often affected by predominant anxious fears for one's health.Aim. To study the efficacy and tolerability of the updated composition of ALERANA® 5% topical spray combined with ALERANA® Serum BIO active complex for hair growth containing minoxidil for the treatment of stress-induced nonscarring alopecia.Materials and methods. A study of ALERANA minoxidil products was conducted. All patients (50 people) underwent comprehensive clinical and laboratory examination and trichoscopic diagnosis. Signs of psycho-emotional distress were diagnosed in 56%, symptoms of autonomic disorders (palpitations, hot flushes, red dermographism, hyperhidrosis) in 21%, sleep disorders in 48%, change in appetite in 18%, muscle tension, spasms in 12%.Results. The amount of hair significantly increased during complex therapy. In the first 3 months of therapy, the average gain was 17%. The appearance of new hair in the parietal and temporal areas, as well as a decline in the number of single follicular units were also observed. ALERANA® spray is highly effective, well tolerated by patients and can be prescribed both as a monotherapy as well as in combination with systemic and local drugs.Conclusion. Identification of mental disorders in patients with chronic types of hair loss, such as alopecia areata and androgenetic alopecia, appears to be an important stage during examination of this group of dermatological patients. The condition for the choice of optimal therapy for a patient is rooted in understanding the pathogenetic factors and correction of possible causes of hair loss. The key to successful treatment of diffuse alopecia is a comprehensive, multifactorial and personalized approach.