Experience With Amphotericin B

Seabury, John H.; Dascomb, Harry E.

doi:10.1111/j.1749-6632.1960.tb20143.x

Cited by 70 publications

(10 citation statements)

References 4 publications

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“…One report utilised amounts as high as 5 mg/dose [129]. Lumbar injections have been used in the treatment of cryptococcus, coccidioidal meningitis, histoplasma and blastomycotic meningitis [111,[121][122][123][124][125][126][127][128][129]. Amphotericin B is often dissolved with either the patient's own CSF fluid or sterile water for injection [122] although D5W has also been used [111].…”

Section: Lumbar Injectionsmentioning

confidence: 99%

“…The standard method of lumbar injections is to perform a lumbar puncture at either the third to fourth or fourth to [111,121,126,128,129]. Hydrocortisone 20 -25 mg is commonly injected at the same time as the amphotericin B or can be added to the solution containing amphotericin B [111,121,126,128,129].…”

Section: Lumbar Injectionsmentioning

confidence: 99%

“…The dose was usually initiated at 0.25 -0.5 mg (maximum 1 mg) given 2 -4 times weekly [111,[121][122][123][124][125][126][127][128]. One report utilised amounts as high as 5 mg/dose [129].…”

Section: Lumbar Injectionsmentioning

confidence: 99%

“…The first method of intrathecal amphotericin B administration described was lumbar or spinal injections [121,122]. The dose was usually initiated at 0.25 -0.5 mg (maximum 1 mg) given 2 -4 times weekly [111,[121][122][123][124][125][126][127][128].…”

Section: Lumbar Injectionsmentioning

confidence: 99%

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Novel modes of antifungal drug administration

Arthur¹,

Drew²,

Perfect³

2004

Expert Opinion on Investigational Drugs

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Administration of antifungals by routes other than that for which the agent was designed or approved have been utilised in attempts to provide directed therapy, reduce adverse effects and improve drug penetration into selected infection sites, such as the central nervous system, lungs and peritoneum. The most widely investigated agent utilising a novel method of drug delivery is amphotericin B. Dose forms for this agent include topicals (aerosol, nasal spray, irrigations, pastes, absorbable sponges, impregnated bone cement and gelatin), oral dosage forms (solutions, suspensions, tablets and so on) and ophthalmic preparations (drops, ointments and injections). Amphotericin B has been administered by routes such as oral, endobronchial, intrathecal, intracisternal, intra-articular, intraperitoneal, ophthalmic and as an antibiotic 'line lock'. Nystatin has been administered as an aerosol, percutaneous paste and bladder washes. Azoles, such as miconazole, fluconazole, ketoconazole and posaconazole, have been administered by novel methods but to a lesser degree. Most of these reports involve miconazole. The dose forms and routes of administration for azoles have included irrigants (bladder, joint), ophthalmic preparations (eye drops, intraocular injections, ointments), impregnated bone cement, endobronchial and intrathecal administration. Finally, both methylene blue (bladder washes) and flucytosine (peritoneal lavage, ophthalmic eye drops) have also been employed. Adequate evaluations of both the safety and efficacy of these therapies are most often hindered by prior or concomitant antifungal therapies, comorbidities and the lack of controlled clinical trials. In addition, the availability of newer treatment options, which demonstrate significant improvement in drug distribution and treatment-related adverse effects make many such novel modes of administration less practical or necessary. In contrast, the inhalation of antifungal aerosols, such as amphotericin B, is rapidly becoming a viable prophylactic option.

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Section: Lumbar Injectionsmentioning

confidence: 99%

Section: Lumbar Injectionsmentioning

confidence: 99%

Section: Lumbar Injectionsmentioning

confidence: 99%

Section: Lumbar Injectionsmentioning

confidence: 99%

See 2 more Smart Citations

Novel modes of antifungal drug administration

Arthur¹,

Drew²,

Perfect³

2004

Expert Opinion on Investigational Drugs

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show abstract

“…Infusion related reactions such as rigors, fever and chills are common (Hiemenz & Walsh, 1998). Moreover, it has been reported that nephrotoxicity is the most common serious adverse effect of Amphotericin B (Gallis et al;Walsh & Dixon;Denning & Stevens;Tollemar & Ringdén;Doubek et al, 2005;Mayer et al, 2002;Seabury & Dascomb, 1960). Even in the setting of maximally tolerated doses of Amphotericin B is frequently fails to control invasive fungal infections, especially in the immunocompromised host.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Amphotericin B Lipid Complex (Abelcet) and Liposomal Amphotericin B (Ambisome) on Rat Kidney: a Morphological Evaluation

et al. 2012

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SUMMARY:The aim of our study was to compare the nephrotoxic effects of liposomal Amphotericin B (Ambisome) and Amphotericin B lipid complex (Abelcet) on rat kidneys at short (14 days) and long term (28 days) treatment applications. Thirty-six male Wistar rats were included and divided into six groups (n=6). Groups 1 and 4 are composed as control groups by administrating intraperitoneal (ip) 0, 9 molar Serum physiologic for a period of 14 and 28 days respectively. Group 2 and 3 are treated with 5 mg/kg Ambisome and 5 mg/kg Abelcet for 14 days respectively, Group 5 and 6 are treated with same agents for 28 days respectively. Then, the rats were transcardially perfused, samples were taken from cortex and medulla regions of kidneys. The micrographs of group 1 and 4 were seen as normal. For short term treatment, some morphological changes were seen in proximal tubule cells in group 3 whereas in group 2 the graphs were observed as normal. However, after long term drug using in group 5 and 6 there were vacuolization, increased lysosomal structures and deep basal folding's into tubular cells lumen. These experiments establish that renal damage were seen in short and long term use of Abelcet and long term use of Ambisome.

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Therapy of Systemic Fungous Infections in 1961

Wilson¹

1961

Arch Intern Med

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Experience With Amphotericin B

Cited by 70 publications

References 4 publications

Novel modes of antifungal drug administration

Novel modes of antifungal drug administration

Comparison of Amphotericin B Lipid Complex (Abelcet) and Liposomal Amphotericin B (Ambisome) on Rat Kidney: a Morphological Evaluation

Therapy of Systemic Fungous Infections in 1961

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