British Journal of Anaesthesia

1972

DOI: 10.1093/bja/44.11.1191

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Experience With Bezitramide and Droperidol en the Treatment of Severe Chronic Pain

P.V. Admiraal¹,

²

,

³

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Cited by 6 publications

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Treatment of Pain Due to Gynecologic Tumors Localized in the Pelvis

1981

Chronic Pelvic Pain in Women

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No abstract

Treatment of Pain Due to Gynecologic Tumors Localized in the Pelvis

1981

Chronic Pelvic Pain in Women

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No abstract

Pharmacokinetics of the oral narcotic analgesic bezitramide and preliminary observations on its effect on experimentally induced pain

³

et al. 1984

Eur J Clin Pharmacol

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The oral absorption of bezitramide 5 mg was studied in 7 human volunteers, using a specific radioimmuno-assay which measured both bezitramide and its active metabolite R-4618. A lag time of 0.5-1.0 h and a Cmax of 5.4 ng/ml plasma were found, the latter occurring 2.5-3.5 h after administration. The apparent elimination half-life varied from 11 to 24 h. Less than 0.3% of the dose was excreted unchanged in the urine. High concentrations in the faeces of some individuals indicate incomplete absorption and/or biliary secretion. The analgesic effect, using a standardized superficial electrical stimulation method, reached its maximum between 2.5 and 3.5 h after dosing, in accordance with the absorption phase. The duration of the effect was highly variable. Experiments in rats (n = 6, 3H-bezitramide 2.5 micrograms), demonstrated extensive biliary excretion (up to 70% of total radioactivity) and less than 3% of the label was removed by urinary excretion.

Treatment of pain in patients with advanced cancer

¹

,

²

,

³

1976

European Journal of Cancer (1965)

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No abstract

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