Experience with pindolol, a betareceptor blocker, in the treatment of hypertension

Atterhög, Jan-Henrik; Dunér, H; Pernow, Bengt

doi:10.1016/0002-9343(76)90907-4

Cited by 59 publications

(17 citation statements)

References 22 publications

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“…In a large literature survey by Man in't Veld and Sehalekamp [2], hemodynamic effects of these beta-blocker gToups have been shown to differ in some respects, both acutely and in the long term [2,4,14]. In our study atenolol decreased heart rate and the rate-pressure product both at rest and dm'ing isometric exercise, while the effect of pindolol was only minirnal.…”

Section: Discussionsupporting

confidence: 43%

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Hemodynamic effects of pindolol and atenolol at rest and during isometric exercise: A noninvasive study with healthy volunteers

Rapola

Pellinen

Koskinen

et al. 1990

Cardiovasc Drug Ther

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Hemodynamic effects of intravenous and oral pindolol and atenolol were assessed in ten healthy volunteers by left ventricular echocardiography and systolic time intervals. Measurements were made at rest and during hand-grip-induced isometric exercise. Drug doses were pindolol 0.015 mg/kg intravenously and 10 mg/day orally, atenolol 0.1 mg/kg intravenously, and 50 mg/day orally. Heart rate at rest was reduced by both drugs. The reduction caused by atenolol during oral treatment was significantly greater (p less than 0.01). Intravenously only pindolol reduced mean arterial pressure. During oral treatment atenolol reduced the mean arterial pressure nonsignificantly. Both drugs lowered heart rate during isometric exercise, atenolol being significantly more effective. During oral treatment atenolol blunted the heart-rate reaction to exercise. Mean arterial pressure during isometric exercise rose slightly with both drugs after intravenous administration. During oral treatment only atenolol reduced the mean arterial pressure significantly. Intravenous atenolol reduced cardiac contractility at rest, indicated by significant decreases in fractional shortening, ejection fraction, and the mean velocity of circumferential fiber shortening. In contrast, intravenous pindolol and oral therapy with either drug did not change contractility. Intravenous atenolol raised total peripheral resistance. The preejection period/left ventricular ejection time ratio decreased with intravenous pindolol, while atenolol increased it. In conclusion, atenolol had more negative inotropic and chronotropic effects, especially after acute intravenous administration. Only atenolol reduced cardiac output and increased peripheral resistance. After repeated oral administration, these effects were less apparent.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 43%

“…In states of minimal adrenergic tone, e.g., during the night, pindolol may even cause an elevation in the resting heart rate [16]. Despite its strong ISA, pindolol has been documented to be an effective antianginal [7] and antihypertensive [3,4,8,14] drug.…”

mentioning

confidence: 99%

Hemodynamic effects of pindolol and atenolol at rest and during isometric exercise: A noninvasive study with healthy volunteers

Rapola

Pellinen

Koskinen

et al. 1990

Cardiovasc Drug Ther

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“…This compound, belonging to a series of drugs commonly known as beta-blockers, is widely used in medical practice in blood pressure control and in the treatment of heart diseases [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Conformational study of isolated pindolol by HF, DFT and MP2 calculations

Nunes

Jesus

Rosado

et al. 2007

Journal of Molecular Structure: THEOCHEM

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In the present work a conformational analysis of pindolol, a beta-blocker, is performed using several computational methods, including HF, DFT (B3LYP) and MP2. The relative electronic energies as well as the relevant dihedral angles of the significant conformer geometries are reported.At the HF and DFT levels the most stable conformers of pindolol are characterized by an extended backbone structure, minimizing the steric repulsions between the indole ring and the side chain. The two backbone dihedrals, defining the position of the ring relatively to the side chain, are found to be particularly important. The lower energy structures obtained by HF and DFT also contribute significantly to the MP2 conformational population. This last method increases the stability of some conformers presenting a more folded backbone.Most conformers exhibit hydrogen bonding. This feature, although not being the dominant factor in energetic terms, appears to be of foremost importance to define the geometry of the molecule. Four intramolecular hydrogen bonds established between the polar groups were identified by the structural geometric parameters. These involved the hydroxyl and amine functional groups and were identified and characterized by the frequency shift in their stretching vibration modes.

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“…In this study we report the results of a double-blind crossover trial comparing four agents which contrast in several of these characteristics. Pindolol is a nonspecific fl-adrenoceptor-blocking drug posessing a relatively high level of intrinsic sympathomimetic activity (Morgan et al, 1972;Atterhog et al, 1976). Metoprolol and atenolol are cardioselective agents which do not possess intrinsic sympathomimetic activity, and labetalol is a non-selective ,Badrenoceptor-blocking drug without intrinsic sympathomimetic activity which in addition has ablocking properties.…”

Section: Introductionmentioning

confidence: 99%

A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

McNeil

Wj²

1979

Brit J Clinical Pharma

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Experience with pindolol, a betareceptor blocker, in the treatment of hypertension

Cited by 59 publications

References 22 publications

Hemodynamic effects of pindolol and atenolol at rest and during isometric exercise: A noninvasive study with healthy volunteers

Hemodynamic effects of pindolol and atenolol at rest and during isometric exercise: A noninvasive study with healthy volunteers

Conformational study of isolated pindolol by HF, DFT and MP2 calculations

A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

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