Experience with the CyberKnife for intracranial stereotactic radiosurgery: Analysis of dosimetry indices

Floriano, Alejandro; Santa-Olalla, I.; Sánchez-Reyes, A.

doi:10.1016/j.meddos.2013.08.005

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Studies examining outcomes in this technology are a minority in comparison with those investigating SRS delivered by non-CK linear accelerators and Gamma Knife (GK; Elekta, Stockholm, Sweden). 24 – 27 Tamari et al analyzed a sample of 109 lesions treated with CK and demonstrated both lesion control at 1 and 2 years (83.3% and 78.5%, respectively) and rates of radionecrosis (7%) comparable to studies using GK and non-CK linear accelerator–based SRS. 27 Tumor volume ( P = .020) and prescription dose ( P = .023) were associated with LC.…”

Section: Discussionmentioning

confidence: 92%

A Dose–Volume Response Model for Brain Metastases Treated With Frameless Single-Fraction Robotic Radiosurgery: Seeking to Better Predict Response to Treatment

Amsbaugh

Gaskins

Dragun

et al. 2016

Technol Cancer Res Treat

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Purpose/Objective(s):To establish a dose–volume response relationship for brain metastases treated with single-fraction robotic stereotactic radiosurgery and identify predictors of local control.Materials/Methods:We reviewed a prospective institutional database of all patients treated for intact brain metastases with stereotactic radiosurgery alone using the CyberKnife robotic radiosurgery system from 2012 to 2015. Tumor response was determined based on Response Evaluation Criteria In Solid Tumors version 1.1. Survival was estimated using the Kaplan-Meier method. Logistic regression modeling was used to identify predictors of outcome and establish a dose–volume response relationship. Receiver operating characteristic curves were constructed to evaluate the predictive capability of the relationship.Results:There were 357 metastases evaluated in 111 patients with a median diameter of 8.14 mm (2.00-40.77 mm). At 6 and 12 months, local control was 86.9% and 82.2%, respectively. For lesions of similar volumes, higher maximum dose, mean dose, and minimum dose (all P values <.05) predicted for better local control. Tumor volume and diameter were strongly correlated, and a dose–volume response relationship was constructed using mean dose per lesion diameter (Gy/mm) that was predictive of local control (odds ratio: 1.34, 95% confidence interval: 1.06-1.70). Area under the receiver operating characteristic curve for local control and mean dose by volume was 0.6199 with a threshold of 2.05 Gy/mm (local failure 7.6% above and 17.3% below 2.05 Gy/mm).Conclusion:A dose–volume response relationship exists for brain metastases treated with robotic stereotactic radiosurgery. Mean dose per volume is strongly predictive of local control and can be potentially useful during stereotactic radiosurgery plan evaluation while respecting previously established dose constraints.

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Section: Discussionmentioning

confidence: 92%

A Dose–Volume Response Model for Brain Metastases Treated With Frameless Single-Fraction Robotic Radiosurgery: Seeking to Better Predict Response to Treatment

Amsbaugh

Gaskins

Dragun

et al. 2016

Technol Cancer Res Treat

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“…For GammaKnife and CyberKnife, CI were similar to our VMAT techniques (CI = 0.77). Floriano et al (29) reported a mean result slightly better (

CI = 0.80 \pm 0.06 Gy

) with 40 patients treated with CyberKnife. Massager et al (30) also investigated this parameter with 203 patients treated for a vestibular schwannomas by GammaKnife and obtained

0.77 \pm 0.08 Gy

, too.…”

Section: Discussionmentioning

confidence: 95%

Comparison of volumetric‐modulated arc therapy and dynamic conformal arc treatment planning for cranial stereotactic radiosurgery

Molinier¹,

Kerr²,

Simeon³

et al. 2016

J Applied Clin Med Phys

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The aim was to analyze arc therapy techniques according to the number and position of the brain lesions reported by comparing dynamic noncoplanar conformal arcs (DCA), two coplanar full arcs (RAC) with volumetric‐modulated arc therapy (VMAT), multiple noncoplanar partial arcs with VMAT (RANC), and two full arcs with VMAT and 10° table rotation (RAT). Patients with a single lesion (n = 10), multiple lesions (n = 10) or a single lesion close to organs at risk (n = 5) and previously treated with DCA were selected. For each patient, the DCA treatment was replanned with all VMAT techniques. All DCA plans were compared with VMAT plans and evaluated in regard to the different quality indices and dosimetric parameters. For single lesion, homogeneity index (HI) better results were found for the RANC technique (0.17±0.05) compared with DCA procedure (0.27±0.05). Concerning conformity index (CI), the RAT technique gave higher and better values (0.85±0.04) compared with those obtained with the DCA technique (0.77±0.05). DCA improved healthy brain protection (8.35±5.61 cc vs. 10.52±6.40 cc for RANC) and reduced monitor unit numbers (3046±374 MU vs. 4651±736 for RANC), even if global room occupation was higher. For multiple lesions, VMAT techniques provided better HI (0.16) than DCA (0.24±0.07). The CI was improved with RAT (0.8±0.08 for RAT vs. 0.71±0.08 for DCA). The normalV10Gy healthy brain was better protected with DCA (9.27±4.57 cc). Regarding the MU numbers: RANC

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The impact of target positioning error and tumor size on radiobiological parameters in robotic stereotactic radiosurgery for metastatic brain tumors

Takizawa

Tanabe

Nakano

et al. 2022

Radiol Phys Technol

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Experience with the CyberKnife for intracranial stereotactic radiosurgery: Analysis of dosimetry indices

Cited by 6 publications

References 19 publications

A Dose–Volume Response Model for Brain Metastases Treated With Frameless Single-Fraction Robotic Radiosurgery: Seeking to Better Predict Response to Treatment

A Dose–Volume Response Model for Brain Metastases Treated With Frameless Single-Fraction Robotic Radiosurgery: Seeking to Better Predict Response to Treatment

Comparison of volumetric‐modulated arc therapy and dynamic conformal arc treatment planning for cranial stereotactic radiosurgery

The impact of target positioning error and tumor size on radiobiological parameters in robotic stereotactic radiosurgery for metastatic brain tumors

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