Experiencia a largo plazo con condroitín sulfato sódico en pacientes con síndrome de vejiga dolorosa

Tornero, Julia; Olarte, Hugo; Escudero, Fuensanta; Gómez, G.

doi:10.1016/j.acuro.2013.01.008

Cited by 3 publications

(1 citation statement)

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“…Chondroitin was used in the linkage with 5-ASA in order to create this novel molecule, a polymeric prodrug. Although chondroitin’s spread usage is an adjuvant for the treatment of osteoarthritis, some studies have proven that it is also efficacious for the treatment of radiation cystitis 26 . The exact mechanism is still unknown, but it is clear that it repairs the defect in the glucosamina-glycane coat in the bladder 27 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in rats

et al. 2021

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Purpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats. Methods: Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups: control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of the findings: inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis. Results: The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C. Conclusion: Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.

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Section: Discussionmentioning

confidence: 99%