EXPERIMENT ON THE GENETIC TOXICITY OF TARTRAZINE YELLOW AND BEHAVIORAL EFFECTS ON Drosophila melanogaster

El-Keredy, Amira

doi:10.21608/ejgc.2018.9497

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Ordinarily, 4–5 sister chromatid exchanges occur for a chromosome pair over one mitosis, whilst 14–100 (SCEs) is not a normal variable and can present a hazard to the organism. A recent study, [27] demonstrated that this synthetic food additive increases the toxicity rate, genotoxicity, mutations and disruption of sex ratio in Drosophila melanogaster model. However, other studies have shown that tartrazine has a potential genotoxic [28] and clastogenic activity.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of blackthorn fruits (Prunus spinosa) against tartrazine toxicity development in albino Wistar rats

et al. 2019

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Background Tartrazine (Yellow 5 or E102) is a synthetic food dye able to modify perception and behavior, causing agitation, confusion, rhinitis and can produce hyperactivity syndrome in children when is combined with benzoates. Additionally, it can trigger oxidative stress which consequently generates metabolic disorders. Therefore, the study was designed to evaluate the harmful effects of the food additive tartrazine and to observe beneficial properties of blackthorn fruits ( Prunus spinosa ) on the blood and organs of albino Wistar rats. Materials and methods This study was carried out on 20 mature Wistar rats, randomly divided into four groups of five animals. Over the course of the experiment, the control group received only food and drinking water, group I received 75 mg of tartrazine dissolved in (250 ml) water group II was given 75 mg of tartrazine and 200 mg of dried blackthorn fruit powder 200 mg dissolved simultaneously in (250 ml) of tartrazine-water mixture (aiming to reduce the tartrazine toxicity) and group III received a higher dose of tartrazine (100 mg) in (250 ml) of water. Results At the end of the experiment, values regarding kidney and liver weight were significantly increased, while the weight of the spleen was slightly decreased compared with the weight of the control group. Biochemical and hematological assays, of the blood samples show that the addition of tartrazine in the diet of rats caused significant changes in all biochemical and hematological parameters of the blood. In the group II, which received ( P. spinosa ) powder combined with tartrazine, the biochemical and hematological parameters had average values similar to the control group. Conclusions Histopathological assay showed that the application of tartrazine in the group I, II and III produced lesions of the kidneys, spleen and the liver for all rodents. Tartrazine was able to generate histopathological changes, which caused significantly tissue lesions of the liver and significant changes in blood parameters. Blackthorn powder showed a promising protective role for the blood parameters but demonstrated no significant benefits for the organs.

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Section: Introductionmentioning

confidence: 99%