Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique

Douarin, Nicole M. Le; Teillet, Marie-Aimée

doi:10.1016/0012-1606(74)90291-7

Cited by 619 publications

(261 citation statements)

References 21 publications

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“…The second is the dorsolateral pathway between the overlying ectoderm and the somites, where cells give rise to Melanocytes (Le Douarin and Teillet, 1974;Le Douarin and Kalcheim, 1999). The NC cells are thought to lose their multipotency before or soon after they emerge from the neural tube becoming restricted in their differentiation abilities depending on the direction of their migration.…”

Section: Introductionmentioning

confidence: 99%

Neural crest cells retain their capability for multipotential differentiation even after lineage‐restricted stages

Motohashi

Yamanaka

Chiba

et al. 2011

Developmental Dynamics

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Multipotency of neural crest cells (NC cells) is thought to be a transient phase at the early stage of their generation; after NC cells emerge from the neural tube, they are specified into the lineage‐restricted precursors. We analyzed the differentiation of early‐stage NC‐like cells derived from Sox10‐IRES‐Venus ES cells, where the expression of Sox10 can be visualized with a fluorescent protein. Unexpectedly, both the Sox10+/Kit− cells and the Sox10+/Kit+ cells, which were restricted in vivo to the neuron (N)‐glial cell (G) lineage and melanocyte (M) lineage, respectively, generated N, G, and M, showing that they retain multipotency. We generated mice from the Sox10‐IRES‐Venus ES cells and analyzed the differentiation of their NC cells. Both the Sox10+/Kit− cells and Sox10+/Kit+ cells isolated from these mice formed colonies containing N, G, and M, showing that they are also multipotent. These findings suggest that NC cells retain multipotency even after the initial lineage‐restricted stages. Developmental Dynamics 240:1681–1693, 2011. © 2011 Wiley‐Liss, Inc.

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Section: Introductionmentioning

confidence: 99%

Neural crest cells retain their capability for multipotential differentiation even after lineage‐restricted stages

Motohashi

Yamanaka

Chiba

et al. 2011

Developmental Dynamics

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“…The neural crest cells in the trunk region migrate through either the ventral or dorsolateral route and differentiate according to their presumptive fate (Le Douarin and Kalcheim 2009). The former cells, which migrate through the ventral pathway, become sensory and autonomic neurons, adrenomedullary cells, and Schwann cells (Weston 1963;Le Douarin and Teillet 1974).…”

mentioning

confidence: 99%

Gene Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs (Fibromelanosis) in Silky Chickens

et al. 2012

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During early development in vertebrates, pluripotent cells are generated from the neural crest and migrate according to their presumptive fate. In birds and mammals, one of the progeny cells, melanoblasts, generally migrate through a dorsolateral route of the trunk region and differentiate to melanocytes. However, Silky is an exceptional chicken in which numerous melanoblasts travel via a ventral pathway and disperse into internal organs. Finally, these ectopic melanocytes induce heavy dermal and visceral melanization known as Fibromelanosis (Fm). To identify the genetic basis of this phenotype, we confirmed the mode of inheritance of Fm as autosomal dominant and then performed linkage analysis with microsatellite markers and sequence-tagged site markers. Using 85 backcross progeny from crossing Black Minorca chickens (BM-C) with F 1 individuals between White Silky (WS) and BM-C Fm was located on 10.2-11.7 Mb of chicken chromosome 20. In addition, we noticed a DNA marker that all Silky chickens and the F 1 individuals showed heterozygous genotyping patterns, suggesting gene duplication in the Fm region. By quantitative real-time PCR assay, Silky line-specific gene duplication was detected as an 130-kb interval. It contained five genes including endothelin 3 (EDN3), which encoded a potent mitogen for melanoblasts/melanocytes. EDN3 with another three of these duplicated genes in Silky chickens expressed almost twofold of those in BM-C. Present results strongly suggest that the increase of the expression levels resulting from the gene duplication in the Fm region is the trigger of hypermelanization in internal organs of Silky chickens.

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“…and Teillet, 1974). However, these cells may also form cartilaginous structures which normally do not receive contribution from the crest.…”

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confidence: 99%

Cyclopamine, a steroidal alkaloid, disrupts development of cranial neural crest cells in Xenopus

Dunn

Mercola

Moore

1995

Developmental Dynamics

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Cyclopamine is a steroidal alkaloid which causes limb and craniofacial defects in many vertebrate species. We have used Xenopus Zaeuis as a model system to characterize the defects caused by cyclopamine at the cellular level. The most dramatic consequence of cyclopamine treatment in the Xenopus embryo is a defect in formation of craniofacial cartilage. Much of this cartilage is absent in treated animals. As in avian and mammalian species, Xenopus craniofacial cartilage is derived primarily from cells of the cranial neural crest. Grafting experiments show that development of the cartilaginous derivatives of the cranial neural crest is impaired after cyclopamine treatment, and this is at least partially due to a direct effect on presumptive crest cells. A culture system was used to determine the cellular response to the drug. Cyclopamine did not block the initial emigration of cells from a neural plate explant. However, cell death is seen in treated cultures after 4 days. Trunk neural crest cells and transformed cell lines are resistant to cyclopamine. We therefore conclude that cyclopamine specifically causes death of cranial neural crest cells and that lethality is likely to account for the teratogenic effects of this compound. 0 1995 Wiley-Liss, Inc.

show abstract

Experimental analysis of the migration and differentiation of neuroblasts of the autonomic nervous system and of neurectodermal mesenchymal derivatives, using a biological cell marking technique

Cited by 619 publications

References 21 publications

Neural crest cells retain their capability for multipotential differentiation even after lineage‐restricted stages

Neural crest cells retain their capability for multipotential differentiation even after lineage‐restricted stages

Gene Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs (Fibromelanosis) in Silky Chickens

Cyclopamine, a steroidal alkaloid, disrupts development of cranial neural crest cells in Xenopus

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