Experimental and computational evaluation of capacitive hyperthermia

Beck, Marcus; Wust, Peter; Oberacker, Eva; Rattunde, Alexander; Päßler, Tom; Chrzon, Benjamin; Veltsista, Paraskevi D.; Nadobny, Jacek; Pellicer-Guridi, Rubén; Herz, Enrico; Winter, Lukas; Budach, Volker; Zschaeck, Sebastian; Ghadjar, Pirus

doi:10.1080/02656736.2022.2048093

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…These preclinical dosages can be compared with clinically achievable doses. An SAR of 20 W/kg (E = 200 V/m) is realistic in the pelvis and abdomen with capacitive systems [ 35 ]. Therefore, a dose of 12,000 V∙min/m can be estimated for a clinical treatment of 60 min.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency Electromagnetic Fields Cause Non-Temperature-Induced Physical and Biological Effects in Cancer Cells

Wust

Veltsista

Oberacker

et al. 2022

Cancers

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Non-temperature-induced effects of radiofrequency electromagnetic fields (RF) have been controversial for decades. Here, we established measurement techniques to prove their existence by investigating energy deposition in tumor cells under RF exposure and upon adding amplitude modulation (AM) (AMRF). Using a preclinical device LabEHY-200 with a novel in vitro applicator, we analyzed the power deposition and system parameters for five human colorectal cancer cell lines and measured the apoptosis rates in vitro and tumor growth inhibition in vivo in comparison to water bath heating. We showed enhanced anticancer effects of RF and AMRF in vitro and in vivo and verified the non-temperature-induced origin of the effects. Furthermore, apoptotic enhancement by AM was correlated with cell membrane stiffness. Our findings not only provide a strategy to significantly enhance non-temperature-induced anticancer cell effects in vitro and in vivo but also provide a perspective for a potentially more effective tumor therapy.

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Section: Discussionmentioning

confidence: 99%