Experimental and computational studies of the interaction of gemifloxacin and manganese (II) gemifloxacin complex with DNA

Firuzabadi, Fahimeh Dehghani; Asadi, Zahra

doi:10.1016/j.molstruc.2020.129248

Cited by 12 publications

(8 citation statements)

References 63 publications

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“…The coordination of the drug to the metal center has caused the stretching vibrations of pyridone and carboxyl groups to be shifted to the lower frequencies of 1612 and 1553 cm −1 , respectively. 33,56 Coordination interactions of the ZIF-8 framework with guests have already been reported. 21,57 The high load value is the result of these interactions.…”

Section: Resultsmentioning

confidence: 94%

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Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria

Soltani

Akhbari

2022

New J. Chem.

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Section: Resultsmentioning

confidence: 94%

“…38,55 In pure drug, the bands at 1628 and 1712 cm À1 belong to the stretching frequencies of the pyridone n(CQO) and carboxyl groups, respectively. 33,56 These two frequencies provide useful information about the drug loading state. As marked in Fig.…”

Section: Fourier-transform Infrared (Ft-ir)mentioning

confidence: 99%

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria

Soltani

Akhbari

2022

New J. Chem.

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“…7(a)), an antibacterial agent to examine whether the complex exhibits better efficacy towards antibacterial activities than the ligand itself. 123 Expectedly, the planarity of the…”

Section: Interaction Of Mn(ii/iii) Complexes Of Drug Molecules With Dnamentioning

confidence: 99%

Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment

Mallick Ganguly,

Moulik

2023

Dalton Trans.

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“…Gemifloxacin is the fourth generation of quinolones (or quinolonecarboxylic acids) that are an essential group of antibacterial agents containing 4-oxo-1,4-dihydroquinoline skeletons and are widely utilized in the medicament of many infections [11][12][13]. The addendum of the fluorine atom to the main quinolones produces fluoroquinolones, which have a much wider range of activity and improved pharmacokinetics [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Characterization of New Gemifloxacin Schiff Base (GMFX-o-phdn) Metal Complexes and Evaluation of Their Antimicrobial Activity against Some Phyto- or Human Pathogens

Elshafie

Sadeek

Camele

et al. 2022

IJMS

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Four novel ligand-metal complexes were synthesized through the reaction of Fe(III), pleaseCo(II), Zn(II), and Zr(IV) with Schiff base gemifloxacin reacted with ortho-phenylenediamine (GMFX-o-phdn) to investigate their biological activities. Elemental analysis, FT-IR, 1H NMR, UV-visible, molar conductance, melting points, magnetic susceptibility, and thermal analyses have been carried out for insuring the chelation process. The antimicrobial activity was carried out against Monilinia fructicola, Aspergillus flavus, Penicillium italicum, Botrytis cinerea, Escherichia coli, Bacillus cereus, Pseudomonas fluorescens, and P. aeruginosa. The radical scavenging activity (RSA%) was in vitro evaluated using ABTS method. FT-IR spectra indicated that GMFX-o-phdn chelated with metal ions as a tetradentate through oxygen of carboxylate group and nitrogen of azomethine group. The data of infrared, 1HNMR, and molar conductivity indicate that GMFX–o-phdn reacted as neutral tetra dentate ligand (N2O2) with metal ions through the two oxygen atoms of the carboxylic group (oxygen containing negative charge) and two nitrogen atoms of azomethine group (each nitrogen containing a lone pair of electrons) (the absent of peak corresponding to ν(COOH) at 1715 cm−1, the shift of azomethine group peak from 1633 cm−1 to around 1570 cm−1, the signal at 11 ppm of COOH and the presence of the chloride ions outside the complex sphere). Thermal analyses (TG-DTG/DTA) exhibited that the decaying of the metal complexes exists in three steps with the final residue metal oxide. The obtained data from DTA curves reflect that the degradation processes were exothermic or endothermic. Results showed that some of the studied complexes exhibited promising antifungal activity against most of the tested fungal pathogens, whereas they showed higher antibacterial activity against E. coli and B. cereus and low activity against P. fluorescens and P. aeruginosa. In addition, GMFX-o-phdn and its metal complexes showed strong antioxidant effect. In particular, the parent ligand and Fe(III) complex showed greater antioxidant capacity at low tested concentrations than that of other metal complexes where their IC50 were 169.7 and 164.6 µg/mL, respectively.

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Experimental and computational studies of the interaction of gemifloxacin and manganese (II) gemifloxacin complex with DNA

Cited by 12 publications

References 63 publications

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria

Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment

Biochemical Characterization of New Gemifloxacin Schiff Base (GMFX-o-phdn) Metal Complexes and Evaluation of Their Antimicrobial Activity against Some Phyto- or Human Pathogens

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Experimental and computational studies of the interaction of gemifloxacin and manganese (II) gemifloxacin complex with DNA

Cited by 12 publications

References 63 publications

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H2O2-sensitive release and potency against infectious bacteria

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H2O2-sensitive release and potency against infectious bacteria

Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment

Biochemical Characterization of New Gemifloxacin Schiff Base (GMFX-o-phdn) Metal Complexes and Evaluation of Their Antimicrobial Activity against Some Phyto- or Human Pathogens

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Product

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Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria

Embedding an extraordinary amount of gemifloxacin antibiotic in ZIF-8 framework with one-step synthesis and measurement of its H₂O₂-sensitive release and potency against infectious bacteria