Experimental and theoretical structural study of 2,9-bis-(4-fluorophenyl)-azaadamantan-4-one ethylene ketal

Assessable Consequences of Through‐Bond Donor–Acceptor Interactions in β‐Aminoketones

“…We have chosen instead to discuss and analyze bond lengths (Figure 5 and Table 2) and angles (Figure 6 and Table 3) in the context of related aza‐ and deaza‐adamantane crystal structures (with crystallographic R factors <0.05) 23. Included in Table 2 is the average bond length data for 6 and 7 , along side data for analogous structures available in the literature (the di‐ (CSD code KOLSIN24) and mono‐ (OCAYEW25) ketones 23 and 24 , respectively) and a saturated aza‐adamantane 25 (EJIQUJ26). 27 Also shown are average bond lengths for three adamantanediones (DESVIG ( 26 ),28 LIXFIH ( 27 ),29 and LIXFUT ( 28 )29), a selected adamantanone (FITPED ( 29 )30), and variously substituted adamantanes ( AD ).…”

Facile construction of the all-bridge-position-functionalized 2,4,6,8-tetraazaadamantane skeleton and conversion of its N-functionalities

“…Considerable progress has also been made in the post-synthesis of azaadamantanes. For example, azaadamantanes with multiple substituents including 4-substituted, 3 a ,13 2,4-, 14 2,6-, 4 3,5- 15 disubstituted, and polysubstituted 3 b ,9 c , d ,11 c ,16 1-azaadamantanes, as well as 2-, 17 4- 18 substituted, 2,6-disubstituted, 19 and polysubstituted 9 b ,17 a ,20 2-azaadamantanes have been simply synthesized. Diazaadamantanes such as 2,6-disubstituted 21 and polysubstituted 20 b ,22 2,6-diazaadamantanes, as well as 4-substituted 23 and polysubstituted 6 b , c ,7 b ,23,24 1,3-diazaadamantanes have also been masterly prepared.…”