Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

Rivera, Antonio; Yáñez, Antonio; León-Tello, Gloria; Gil, Constantino; Giono, S; Barba, Eduardo; Cedillo, Lilia

doi:10.1186/1471-2474-3-15

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…fermentans P-140 was used in the adherence inhibition assays since it showed a greater adherence to HEp-2 cells than PG-18 and also showed the highest virulence in inducing experimental arthritis [20] and experimental pneumonia [21]. Pathogenic mycoplasmas induce acute or chronic debilitating diseases and mayalter immune function.…”

Section: Discussionmentioning

confidence: 99%

“…Mycoplasmal products could stimulate the secretion of cytokines involved in the development of arthritis [20] and could create the basis for further damage to the joint.…”

Section: Fermentans Adherence To Cultured Epithelial Cellsmentioning

confidence: 99%

“…M. fermentans is currently being examined as an agent potentially associated with human diseases, including infectious processes affecting immunocompromised individuals and patients with rheumatoid arthritis [17]- [19]. In a previous study, we induced experimental arthritis injecting the bacteria (M. fermentans P-140) in the knee joints of rabbits, which resulted in a systemic infection demonstrating the microorganism's ability to disseminate throughout the animal [20]. In a recent paper we have shown that M. fermentans is able to produce severe respiratory disease in a hamster model [21].…”

Section: Introductionmentioning

confidence: 99%

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Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells

Rosales-Pérez¹,

Cerezo²,

Girón³

et al. 2014

AiM

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This study compares the kinetics of adherence of both the prototype strain PG-18 and the recently clinically isolated strain P-140 of Mycoplasma fermentans to HEp-2 cells. M. fermentans may induce respiratory and genitourinary tract infections. We investigated the presence of putative adhesins from strain P-140. A surface protein of 47 kDa, labeled SP47, isolated from M. fermentans P-140, seems to be involved in acterial adherence on HEp-2 cells; this study could allow helping understand the interaction between mycoplasmas and their hosts. Anti-SP47 antibodies inhibited the formation of bacterial clusters and adherence to cultured cells, quantified by ELISA. M. fermentans P-140 was more efficient at adhering to cultured HEp-2 cells than PG-18.

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Section: Discussionmentioning

confidence: 99%

“…Mycoplasmal products could stimulate the secretion of cytokines involved in the development of arthritis [20] and could create the basis for further damage to the joint.…”

Section: Fermentans Adherence To Cultured Epithelial Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells

Rosales-Pérez¹,

Cerezo²,

Girón³

et al. 2014

AiM

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“…fermentans injected into the joints of rabbits [15]. Outbreaks of rheumatic disease, such as polyarthritis, have been traced to infections by Mycoplasma species [16].…”

Section: Letter To Editormentioning

confidence: 99%

“…For example, infections with Mycoplasma species, Borrelia species and other intracellular bacteria have been linked to various forms of rheumatic disease [1][2][3][4][6][7][8][9][10][11][12][13]. In addition, animal models of rheumatic disease have been established by infection with Mycoplasma species [13][14][15]. In one of these contributions experimental arthritis was induced by a clinical isolate from M.…”

Section: Letter To Editormentioning

confidence: 99%

Mycoplasma and other Intracellular Bacterial Infections in Rheumatic Diseases: Comorbid Condition or Cause?

Nicolson¹

2017

Open J Trop Med

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Antigens: Lipids

Matsuda¹

2011

Encyclopedia of Life Sciences

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Molecular mechanisms of lipid‐antigen recognition are important in the frontier of immunology. Possible pathogeneses of autoimmune diseases and tumours now include infections with microorganisms. Therefore, the role of vaccines is increasingly important, as advancing technology has now broadened the targets of vaccination to include a greater number of infectious diseases, tumours, chronic infections, autoimmune diseases and allergies. To prevent infectious diseases through vaccination, it is important to identify specific antigens, which often exist in the cell membrane and capsule and also become the centre of host–pathogen interactions. Structural analysis of lipid‐antigens is critical for understanding the mechanisms of molecular interactions involved in the pathogenesis of immune abnormalities, and for devising strategies surrounding immune system regulation and drug discovery. Key Concepts: Until recently, it had been the paradigm that T cells recognise peptide antigens that are presented by major histocompatibility complex (MHC) class I or II molecules. It has now been demonstrated that lipids can be presented by antigen‐presenting cells (APC) through the CD1 family of molecules. The structures of the CD1 family of molecules are similar to those of MHC class I and II molecules. It is now recognised that continued immunological stimulus by chronic or repetitive infections with microorganisms can result in disease mechanisms that are seen in autoimmune diseases and tumours. Glycolipids and phospholipids are major components of biomembranes (lipid bilayers) in which hydrophobic tail groups aggregate and form micelles with head groups facing towards the outside membrane. Glycolipids and phospholipids play important roles in intracellular vesicular trafficking; for example, in the endoplasmic reticulum. Some human diseases are caused by antiphospholipid antibodies (antiphospholipid syndrome) and by antiglycolipid antibodies (antiglycolipid syndrome). Microbial cell walls, which contain glycolipids and phospholipids, are rich in antigens. Such antigens are located on the surface of the microbial cell membranes and are therefore important in the host recognition of microbial infections and subsequent immune responses in higher organisms. Although there are exceptions to these generalisations, Gram‐negative bacteria contain lipopolysaccharide (LPS) anchored by lipid A, Gram‐positive bacteria contain lipoteichoic acid (LTA) structures consisting mainly of glycerolipids, mycobacteria contain lipoarabinomannan (LAM), and mammalian cells contain glycerolipids and sphingolipids. Autoreactivity is much more common than autoimmune disease and does not always results in illness. Autoimmune diseases can best be understood as being a result of multistep processes with a loss of self‐tolerance. Autoimmune diseases require development of autoreactivity as well as initiation of effector mechanisms. Since mycoplasmas are contained only by a plasma membrane, it has been thought that lipid antigens in the cell membrane play an important role in the immune response against them. Mycoplasma lipid‐antigens (mycoplasma‐mimic particles) present carbohydrates as specific antigens for antibody‐mediated humoral immunity and present lipid‐antigen‐specific characters for cellular immunity. Key lipid‐antigens and their structures can be used to understand the mechanisms of molecular interactions and pathogenesis of immune abnormalities, and can be used to devise strategies for immune system regulation and drug discovery. The role of vaccines is increasingly important in medicine because advancing technology has broadened the targets of vaccination to include a greater number of infectious diseases, autoimmune diseases, tumours, chronic infections and allergies.

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Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

Cited by 16 publications

References 19 publications

Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells

Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells

Mycoplasma and other Intracellular Bacterial Infections in Rheumatic Diseases: Comorbid Condition or Cause?

Antigens: Lipids

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Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

Cited by 16 publications

References 19 publications

Adherence of a Clinical Strain of &lt;i&gt;Mycoplasma fermentans&lt;/i&gt; to Human Cultured Epithelial Cells

Adherence of a Clinical Strain of &lt;i&gt;Mycoplasma fermentans&lt;/i&gt; to Human Cultured Epithelial Cells

Mycoplasma and other Intracellular Bacterial Infections in Rheumatic Diseases: Comorbid Condition or Cause?

Antigens: Lipids

Contact Info

Product

Resources

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Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells

Adherence of a Clinical Strain of <i>Mycoplasma fermentans</i> to Human Cultured Epithelial Cells