Experimental assignment of long-range magnetic communication through Pd &amp; Pt metallophilic contacts

Larsen, Emil M. H.; Bonde, Niels A.; Weihe, Høgni; Ollivier, Jacques; Vosch, Tom; Lohmiller, Thomas; Holldack, K.; Schnegg, Alexander; Perfetti, Mauro; Bendix, Jesper

doi:10.1039/d2sc05201f

Cited by 2 publications

(1 citation statement)

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“…Heterometallic coordination compounds are of high interest in various fields, spanning from catalysis [20][21][22][23] to molecular magnetism [24][25][26][27][28]. Obtaining such structures is not a trivial task, and a tailored design of employed ligands, eventually heterotopic ones [29][30][31], is often necessary.…”

Section: Introductionmentioning

confidence: 99%

Structural and Magnetic Properties of the {Cr(pybd)3[Cu(cyclen)]2}(BF4)4 Heteronuclear Complex

et al. 2023

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Heterotopic ligands containing chemically different binding centers are appealing candidates for obtaining heteronuclear metal complexes. By exploiting this strategy, it is possible to introduce different paramagnetic centers characterized by specific anisotropic magnetic properties that make them distinguishable when weakly magnetically coupled. This molecular approach has great potential to yield multi-spin adducts capable of mimicking logical architectures necessary for quantum information processing (QIP), i.e., quantum logic gates. A possible route for including a single-ion magnetic center within a finite-sized heterometallic compound uses the asymmetric (1-pyridyl)-butane-1,3-dione (pybd) ligand reported in the literature for obtaining Cr3+−Cu2+ metallo-cages. To avoid the formation of cages, we adopted the cyclen (1,4,7,10-tetraazacyclododecane) ligand as a “capping” agent for the Cu2+ ions. We report here the structural and magnetic characterization of the unprecedented adduct {Cr(pybd)3[Cu(cyclen)]2}(BF4)4, whose structure is characterized by a central Cr3+ ion in a distorted octahedral coordination environment and two peripheral Cu2+ ions with square-pyramidal coordination geometries. As highlighted by Continuous Wave Electron Paramagnetic Resonance (EPR) spectroscopy and Direct Current (DC) magnetometry measurements, this adduct shows negligible intramolecular magnetic couplings, and it maintains the characteristic EPR signals of Cr3+ and Cu2+ moieties when diluted in frozen solutions.

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Section: Introductionmentioning

confidence: 99%

Structural and Magnetic Properties of the {Cr(pybd)3[Cu(cyclen)]2}(BF4)4 Heteronuclear Complex

et al. 2023

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Comparison of metagenomic and targeted methods for sequencing human pathogenic viruses from wastewater

Child,

Airey,

Maloney

et al. 2023

mBio

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Wastewater-based epidemiology is a powerful tool for monitoring the emergence and spread of viral pathogens at the population scale. Typical polymerase chain reaction (PCR)-based methods of quantitative and genomic monitoring of viruses in wastewater provide high sensitivity and specificity. However, these methods are limited to the surveillance of target viruses in a single assay and require prior knowledge of the target genome(s). Metagenomic sequencing methods may represent a target-agnostic approach to viral wastewater monitoring, allowing for the detection of a broad range of target viruses, including potentially novel and emerging pathogens. In this study, targeted and untargeted metagenomic sequencing methods were compared with tiled-PCR sequencing for the detection and genotyping of viral pathogens in wastewater samples. Deep shotgun metagenomic sequencing was unable to generate sufficient genome coverage of human pathogenic viruses for robust genomic epidemiology, with samples dominated by bacteria. Hybrid-capture enrichment of shotgun libraries for respiratory viruses led to significant increases in genome coverage for a range of targets. Tiled-PCR sequencing led to further improvements in genome coverage compared to hybrid capture for severe acute respiratory syndrome coronavirus 2, enterovirus D68, norovirus GII, and human adenovirus F41 in wastewater samples. In conclusion, untargeted shotgun sequencing was unsuitable for genomic monitoring of the low virus concentrations in wastewater samples analyzed in this study. Hybrid-capture enrichment represented a viable method for simultaneous genomic epidemiology of a range of viral pathogens, while tiled-PCR sequencing provided the optimal genome coverage for individual viruses with the minimum sequencing depth. IMPORTANCE Most public health initiatives that monitor viruses in wastewater have utilized quantitative polymerase chain reaction (PCR) and whole genome PCR sequencing, mirroring techniques used for viral epidemiology in individuals. These techniques require prior knowledge of the target viral genome and are limited to monitoring individual or small groups of viruses. Metagenomic sequencing may offer an alternative strategy for monitoring a broad spectrum of viruses in wastewater, including novel and emerging pathogens. In this study, while amplicon sequencing gave high viral genome coverage, untargeted shotgun sequencing of total nucleic acid samples was unable to detect human pathogenic viruses with enough sensitivity for use in genomic epidemiology. Enrichment of shotgun libraries for respiratory viruses using hybrid-capture technology provided genotypic information on a range of viruses simultaneously, indicating strong potential for wastewater surveillance. This type of targeted metagenomics could be used for monitoring diverse targets, such as pathogens or antimicrobial resistance genes, in environmental samples.

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Experimental assignment of long-range magnetic communication through Pd & Pt metallophilic contacts

Abstract: Record-breaking magnetic exchange interactions have previously been reported for 3d-metal dimers of the form [M(Pt(SAc)4)(pyNO2)]2 (M=Ni or Co) that are linked in the solid state via metallophilic Pt···Pt bridges. This...

Cited by 2 publications

References 48 publications

Structural and Magnetic Properties of the {Cr(pybd)3[Cu(cyclen)]2}(BF4)4 Heteronuclear Complex

Structural and Magnetic Properties of the {Cr(pybd)3[Cu(cyclen)]2}(BF4)4 Heteronuclear Complex

Comparison of metagenomic and targeted methods for sequencing human pathogenic viruses from wastewater

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