Experimental bacterial prostatitis in rats

Goto, Toshihiro; Kawahara, Masashi; Kawahara, Kazuya; Mahinose, S.; Mizuma, Yoshihiro; Sakamoto, Nobuaki; Ohi, Yoshiaki

doi:10.1007/bf00368193

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…Microorganisms gain access to renal tubules by a calicotubular reflux or via the blood or lymphatic vessels. This most likely correlates, as stated before, with a relatively higher incidence of prostate and bladder changes in males (Goto et al 1991) and is also observed experimentally. This was attributed to ureter obstruction since, if released soon after being created, the consequences are alleviated (Claesson et al 1987).…”

Section: Biologic Featuressupporting

confidence: 85%

Urinary System

1998

Monographs on Pathology of Laboratory Animals

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Section: Biologic Featuressupporting

confidence: 85%

Urinary System

1998

Monographs on Pathology of Laboratory Animals

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“…Experimental chronic bacterial prostatitis was induced by the instillation of a bacterial suspension ( Escherichia coli , 10 8 colony-forming units [CFU]/mL) into the prostatic urethra. Previous studies have suggested that intraurethral inoculation is the best method of producing bacterial prostatitis in rats [11]. …”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory and Antimicrobial Effects of a Novel Herbal Formulation (WSY-1075) in a Chronic Bacterial Prostatitis Rat Model

Park

Jeong

Moon

et al. 2016

World J Mens Health

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PurposeThe aim of this study was to investigate the anti-inflammatory and anti-oxidative effects of a multi-herbal formula known as WSY-1075 in the treatment of chronic bacterial prostatitis in a rat model.Materials and MethodsExperimental chronic bacterial prostatitis was induced in 32 Wistar rats by instillation of a bacterial suspension (Escherichia coli, 108 colony-forming units [CFU]/mL) into the prostatic urethra. After the induction of prostatitis, the rats were randomly divided into one of 4 treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (400 mg/kg) (n=8), and WSY-1075 (400 mg/kg)+ciprofloxacin (n=8). After 4 weeks of treatment, microbiological data from prostate tissue cultures, level of prostatic pro-inflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin [IL]-6, and IL-8), anti-oxidant effects (superoxide dismutase [SOD]), and histological findings were noted.ResultsThe WSY-1075, ciprofloxacin, and WSY-1075+ciprofloxacin groups showed fewer CFUs in prostate tissue cultures than the control group. The WSY-1075, ciprofloxacin and WSY-1075+ciprofloxacin groups showed statistically significantly lower levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-8 than the control group. SOD levels in the WSY-1075, ciprofloxacin and WSY-1075+ciprofloxacin groups were significantly higher than in the control group.ConclusionsThis study found that WSY-1075 had anti-microbial effects, anti-inflammatory effects, and anti-oxidative effects in a chronic bacterial prostatitis rat model. We expect the WSY-1075 may be useful for the clinical treatment of chronic bacterial prostatitis.

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“…Інфекційні агенти потрапляють до передміхурової залози гематогенним та лімфогенним шляхами або через систему вивідних протоків залози з уретрального каналу, а також ретроградно через рефлюкси з сечового міхура (Johnston, Kamolpatana, Root-Kustritz, & Johnston, 2000;Tsvetkov, Makarova, & Mkhytarov, 2013 (Nickel еt al., 1990) та відтворена (Goto et al, 1991).…”

Section: сумской национальный аграрный университет сумы украинаunclassified

Microflora of the urinal channel of dogs for prostatitis and sensitivity to antibiotics

Bondar¹

2019

VTTP

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The results of microflora research of urinal canal of dogs with prostatitis and its sensitiveness to the antibiotics are shown. The aim of researches was to set the microflora of nephrogonoduct in clinically healthy dogs and microflora of urethral excretions at chronic prostatitis, and also its sensitiveness to the different groups of antibiotics. With the aim of research of biological properties of microflora of nephrogonoduct and urethral excretions at chronic prostatitis were selected 20 animals that were divided into 2 groups. The first group was laid down clinically by healthy animals, (n=10) and second-diseases with chronic prostatitis (n=10). Both patients and clinically healthy dogs was taken microbal material that was sown by a superficial and deep way on the agar nourishing environments of two types-МРА and environment of Еndo. Family belonging was found out on morphological and biological properties. The sensitiveness of microorganisms to the antibiotics was determined by the method of diffusion in an agar with the use of paper disks after the sizes of zones of oppression of height round a disk, on the methodology accepted in general lines. For research it was used 10 preparations: ceftriaxon, cefazolin, cefalexin, tylosin, gentamicin, tetracyclinum, enrofloxacinn, erythromysin, amoxycillin and penbex. The analysis of the obtained data asserted that the mixed urethral microflora distinguished from dogs with prostatitis showed an insignificant sensitiveness to the gentamicin and tetracyclinum, as a diameter of zone of detention of height of microorganisms of the mixed culture was very small or is quite absent, that is why expediency of their use is under a question, obviously, unjustified, taking into account considerable course duration of antibiotic therapy of chronic prostatitis. It is able to do a bactericidal and bacteriostatix action among antibiotics.

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Experimental bacterial prostatitis in rats

Cited by 8 publications

References 6 publications

Urinary System

Urinary System

Anti-Inflammatory and Antimicrobial Effects of a Novel Herbal Formulation (WSY-1075) in a Chronic Bacterial Prostatitis Rat Model

Microflora of the urinal channel of dogs for prostatitis and sensitivity to antibiotics

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