Experimental Bacteroides fragilis endocarditis in rabbits

Carrizosa, Jaime; Tanphaichitra, D; Levison, Matthew E.

doi:10.1128/iai.15.3.871-873.1977

Cited by 17 publications

(8 citation statements)

References 4 publications

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“…This investigation has used the rabbit model for aspergillus endocarditis (Carrizosa, Kohn & Levison, 1975) to investigate the efficacy of treatment with three antifungal agents. The assessment of endocarditis differed from that reported previously (Carrizosa et al, 1975) in that no attempt was made to estimate the quantity of aspergillus in the vegetations. In an extensive series of initial investigations (M. V. Martin & L. P. Longman, unpublished work) the number of colony-forming units recovered from infected vegetations was not proportional to thrombus weight.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the efficacy of itraconazole, amphotericin B and 5-fluorocytosine in the treatment of Aspergillus fumigatus endocarditis in the rabbit

Longman

Martin

1987

J Antimicrob Chemother

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The efficacy of amphotericin B, 5-fluorocytosine and itraconazole was compared for the treatment of experimental rabbit Aspergillus fumigatus endocarditis. Therapy with amphotericin B or 5-fluorocytosine, at dosages of 3.0 and 35 mg/kg body weight respectively, failed to eradicate aspergillus from the cardiac vegetations in all but one of the animals tested; none of these animals survived for longer than nine treatment days. When similar doses of amphotericin and 5-fluorocytosine were administered concomittantly, 30% of the animals had sterile vegetations. Itraconazole at 2.5 and 3.5 mg/kg body weight was not successful; all the animals tested had infected vegetations and did not survive beyond nine days of therapy. In contrast, itraconazole at 5.0 mg/kg sterilised the endocardial vegetations and all these animals survived for 14 days. It is concluded that itraconazole may be useful in the treatment of aspergillus endocarditis.

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Section: Discussionmentioning

confidence: 99%

A comparison of the efficacy of itraconazole, amphotericin B and 5-fluorocytosine in the treatment of Aspergillus fumigatus endocarditis in the rabbit

Longman

Martin

1987

J Antimicrob Chemother

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“…Culture methods. For inoculation of rabbits, E. corrodens was grown in broth (CS3) containing the following ingredients per liter of distilled water: Trypticase (BBL), 17.0 g; Phytone (BBL), 3.0 g; potassium nitrate, 1.0 g; sodium formate, 1.0 g; and hemin, 3 mg. Hemin was added as 1 ml of a 0.3% sterile solution in 1 M sodium carbonate. Incubation of all cultures was at 370C under an atmosphere of 80% Ar, 10% CO2, and 10% H2, in a gas-replacement jar containing Pd catalyst.…”

Section: Methodsmentioning

confidence: 99%

Experimental Eikenella corrodens endocarditis in rabbits

Badger¹,

Bütler²,

Kim³

et al. 1979

Infect Immun

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The ability of Eikenella corrodens to cause endocarditis in catheterized rabbits was studied. E. corrodens 1073, the serum-resistant strain used in the study, was isolated from a human periodontitis lesion. Thirty-four rabbits, surgically catheterized across the aortic valve and injected intravenously 24 to 48 h later with 107 to 109 log-phase organisms, were studied. Only three rabbits developed positive

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“…Models of systemic fungal infection have also been described in rabbits and include C. albicans [62], A. fumigatus [63Á66] and S. prolificans [67]. Other models including pulmonary aspergillosis [68,69], candidiasis [70,71] and cryptococcosis [72], sinusitis [73Á75], endocarditis caused by Aspergillus [76] or Candida [77,78]. Rabbit models of Aspergillus have been reviewed in greater detail elsewhere [35,79Á81].…”

Section: Types Of Animalsmentioning

confidence: 99%

Animal models: an important tool in mycology

2007

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Animal models of fungal infections are, and will remain, a key tool in the advancement of the medical mycology. Many different types of animal models of fungal infection have been developed, with murine models the most frequently used, for studies of pathogenesis, virulence, immunology, diagnosis, and therapy. The ability to control numerous variables in performing the model allows us to mimic human disease states and quantitatively monitor the course of the disease. However, no single model can answer all questions and different animal species or different routes of infection can show somewhat different results. Thus, the choice of which animal model to use must be made carefully, addressing issues of the type of human disease to mimic, the parameters to follow and collection of the appropriate data to answer those questions being asked. This review addresses a variety of uses for animal models in medical mycology. It focuses on the most clinically important diseases affecting humans and cites various examples of the different types of studies that have been performed. Overall, animal models of fungal infection will continue to be valuable tools in addressing questions concerning fungal infections and contribute to our deeper understanding of how these infections occur, progress and can be controlled and eliminated.

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Experimental Bacteroides fragilis endocarditis in rabbits

Cited by 17 publications

References 4 publications

A comparison of the efficacy of itraconazole, amphotericin B and 5-fluorocytosine in the treatment of Aspergillus fumigatus endocarditis in the rabbit

A comparison of the efficacy of itraconazole, amphotericin B and 5-fluorocytosine in the treatment of Aspergillus fumigatus endocarditis in the rabbit

Experimental Eikenella corrodens endocarditis in rabbits

Animal models: an important tool in mycology

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