Experimental datasets on the immunohistological assessment of δ-cells in the islet organs of the endocrine pancreas of Japanese medaka (Oryzias latipes) fish exposed to graphene oxide

A systematic review of the evaluation of endocrine-disrupting chemicals in the Japanese medaka (Oryzias latipes) fish

“…In addition, several of the unclassified EDCs have potential as ESR agonists (CMP, DIBP, and FU) or antagonists (CYN, PHT, and RLX), and the ESR agonist and ARβ agonist (INT) and ESR agonist and ARβ antagonist (CMP) were observed in in vitro RGA with medaka esr1 and arβ genes ( Onishi et al, 2021 ; Kawashima et al, 2022 ). Moreover, the nanocarbon, GO, was evaluated in 10 articles targeting the gonads, thyroid, interrenal glands, and pancreas in adults; and gonads, thyroids, and interrenal glands in larvae ( Dasmahapatra et al, 2020a ; Dasmahapatra et al, 2020b ; Dasmahapatra and Tchounwou, 2022a ; Dasmahapatra and Tchounwou, 2022b ; Dasmahapatra and Tchounwou, 2023a ; Dasmahapatra and Tchounwou, 2023b ; Asala et al, 2021 ; 2022 ; Myla et al, 2021a ; b ). Despite the histopathological alterations and cellular disruptions induced in the gonads, liver, kidneys, thyroid, interrenal glands, and pancreas of the adults and larvae of Japanese medaka by GO, due to the lack of specific Tier 1 and Tier 2 tests, GO remained unclassified without identifying any EATS-specific pathways ( Dasmahapatra et al, 2020a ; Dasmahapatra et al, 2020b ; Dasmahapatra and Tchounwou, 2022a ; Dasmahapatra and Tchounwou, 2022b ; Dasmahapatra and Tchounwou, 2023a ; Dasmahapatra and Tchounwou, 2023b ; Asala et al, 2021 ; 2022 ; Myla et al, 2021a ; b ).…”

“…Due to the lack of validated in vivo or in vitro methods and the availability of the appropriate literature in the public databases, the evaluation of EDCs targeting non-EATS modalities of Japanese medaka is not properly focused on this review. Our literature search on the effects of EDCs on the endocrine pancreas and interrenal glands of Japanese medaka found only four articles, two for pancreas ( Dasmahapatra and Tchounwou, 2023a ; Dasmahapatra and Tchounwou, 2023b ), and two for interrenal glands ( Dasmahapatra and Tchounwou, 2022a ; Dasmahapatra and Tchounwou, 2022b ) ( Tables 2 , 11 ) in PubMed ( www.ncbi.gov ). Therefore, despite the significant importance of non-EATS modalities in Japanese medaka, due to the lack of sufficient literature and standard methods, the evaluation of EDCs mediated through non-EATS pathways is not appropriately described in this review article.…”

“…Moreover, the nanocarbon, GO, was evaluated in 10 articles targeting the gonads, thyroid, interrenal glands, and pancreas in adults; and gonads, thyroids, and interrenal glands in larvae (Dasmahapatra et al, 2020a;Dasmahapatra et al, 2020b;Dasmahapatra and Tchounwou, 2022a;Dasmahapatra and Tchounwou, 2022b;Dasmahapatra and Tchounwou, 2023a;Dasmahapatra and Tchounwou, 2023b;Asala et al, 2021;Myla et al, 2021a;. Despite the histopathological alterations and cellular disruptions induced in the gonads, liver, kidneys, thyroid, interrenal glands, and pancreas of the adults and larvae of Japanese medaka by GO, due to the lack of specific Tier 1 and Tier 2 tests, GO remained unclassified without identifying any EATS-specific pathways (Dasmahapatra et al, 2020a;Dasmahapatra et al, 2020b;Dasmahapatra and Tchounwou, 2022a;Dasmahapatra and Tchounwou, 2022b;Dasmahapatra and Tchounwou, 2023a;Dasmahapatra and Tchounwou, 2023b;Asala et al, 2021;Myla et al, 2021a;. Therefore, we think that, before excluding the potential of these unclassified chemicals as an ED, further validations using tier-based approaches are necessary.…”

“…Moreover, 45 unidentified EDCs in 60 sorted articles indicated that one chemical remained unidentified in 1.33 articles reviewed (4 articles:3 chemicals). Among these chemicals, the ED potential of GO was described in the maximum number of articles (10 articles) targeting the gonads, thyroid, interrenal glands, and endocrine pancreas of Japanese medaka (Dasmahapatra et al, 2020a;Dasmahapatra et al, 2020b;Myla et al, 2021;Asala et al, 2021;Myla et al, 2021;Dasmahapatra and Tchounwou, 2022a;Asala et al, 2022;Dasmahapatra and Tchounwou, 2022b;Dasmahapatra and Tchounwou, 2023a;Dasmahapatra and Tchounwou, 2023b). Moreover, TBT, a biocide used in agriculture, has been studied in six articles and showed the potential to inhibit brain aromatase in Japanese medaka (Nozaka et al, 2004;Khul and Brouwer, 2006;Hano et al, 2007;Zhang et al, 2008;Horie et al, 2018;Horie et al, 2022a).…”

“…In this review, we summarized the data on EDCs available in public databases, highlighting the links between molecular, phenotypic, and physiological endpoints using Japanese medaka as a single fish species. Although majority of the data refer to interfering with reproductive and thyroid hormone signaling pathways (EATS), limited information about the disruption of other endocrine organs, like the endocrine pancreas and interrenal gland (fish homolog of the adrenal gland), is also available ( Dasmahapatra and Tchounwou, 2022a ; b , 2023a ; b ). We evaluated the selective effects of 128 EDCs reported in 205 articles.…”