Experimental design-based development of a rapid capillary electrophoresis method for determining impurities in the tetrapeptide H-Tyr-(d)Arg-Phe-Phe-NH2

Brunnkvist, Helena; Karlberg, Bo; Astervik, Åsa; Granelli, Ingrid

doi:10.1016/j.jchromb.2004.04.031

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Cited by 5 publications

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References 18 publications

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“…Factorial experiments allow experiments to take place over the whole range of the factor space. They show a high degree of precision in exchange for a minimum experimental effort, and they enable factor interactions to be detected [1,2]. In order to increase efficiency of method development, we used a systemic design in establishing one analytical method.…”

Section: Introductionmentioning

confidence: 99%

Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics

Lin

Yang

2007

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics

Lin

Yang

2007

Journal of Pharmaceutical and Biomedical Analysis

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Application of Chemometric Methods in Drug Purity Determination by Capillary Electrophoresis

Scriba

2009

Chemometric Methods in Capillary Electrophoresis

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Development of a CZE method for the determination of mizolastine and its impurities in pharmaceutical preparations using response surface methodology

et al. 2007

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A fast and selective CZE method for the determination of mizolastine and related impurities is described. Response surface methodology was applied to study the influence of phosphate/triethanolamine (TEA) buffer concentration, heptakis(2,3,6-tri-O-methyl)-beta-CD (TMbetaCD) concentration, voltage and temperature. The optimum conditions were: 105 mM phosphate/TEA buffer (pH 3.0) containing 10 mM TMbetaCD, temperature 19 degrees C and voltage 30 kV. Validation of the method was performed in drug substance and drug product. Robustness was evaluated using a Plackett-Burman design, including pH among the considered factors. Applying the optimal conditions, the nine peaks were baseline separated in about 10 min. The method was applied to the quality control of mizolastine in controlled-release tablets.

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Experimental design-based development of a rapid capillary electrophoresis method for determining impurities in the tetrapeptide H-Tyr-(d)Arg-Phe-Phe-NH2

Cited by 5 publications

References 18 publications

Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics

Experimental design and capillary electrophoresis for simultaneous analysis of arbutin, kojic acid and hydroquinone in cosmetics

Application of Chemometric Methods in Drug Purity Determination by Capillary Electrophoresis

Development of a CZE method for the determination of mizolastine and its impurities in pharmaceutical preparations using response surface methodology

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