Experimental design for functional MRI of scene memory encoding

Narayan, Veena M.; Kimberg, Daniel Y.; Tang, Kathy Z.; Detre, John A.

doi:10.1016/j.yebeh.2004.12.006

Cited by 16 publications

(19 citation statements)

References 27 publications

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“…The present block design to manipulate novelty was chosen because it represents one of the most robust means to elicit reliable MTL responses with fMRI in individual participants (Narayan et al, 2005;Westmacott et al, 2008). This approach allowed us to reveal direct signs of functional integrity in NB's spared left hippocampus and to specify viable neuroanatomical mechanisms that could support hippocampal functioning in the presence of partial de-afferentiation.…”

Section: Discussionmentioning

confidence: 99%

“…We used a novelty paradigm in combination with a block design, because this approach represents one of the most robust means to elicit reliable hippocampal responses with fMRI in individual participants (Narayan et al, 2005;Westmacott et al, 2008). Moreover, novelty signals in the hippocampus have specifically been linked to processing of the types of relationships between stimuli and their context that are critical for episodic recollection, i.e., the process that operates normally in NB (Ranganath and Rainer, 2003;Nyberg, 2005;Kumaran and Maguire, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Preserved hippocampal novelty responses following anterior temporal‐lobe resection that impairs familiarity but spares recollection

et al. 2011

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Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of a lesion to perirhinal cortex that produces noticeable memory impairments. This question is intriguing as the MTL forms a hierarchical system, in which perirhinal cortex represents one of the critical nodes in the reciprocal projections between neocortical association areas and the hippocampus. Here, we used functional magnetic resonance imaging to examine whether NB, an individual who underwent surgical resection of the left anterior temporal lobe that included large aspects of perirhinal and entorhinal cortex but spared the hippocampus, exhibits intact hippocampal novelty responses to auditory sentences. Our results revealed such evidence in NB's left and right hippocampus. They complement previous behavioral work in NB, indicating that recollective processes considered to rely on hippocampal integrity are also preserved. Further analyses revealed intact novelty responses in structures that provide neuroanatomical input to the hippocampus, including remaining perirhinal cortex and surgically spared parahippocampal cortex. These findings point to viable neuroanatomical mechanisms as to how functional integrity in the hippocampus may be maintained in the face of widespread, but incomplete removal of its input structures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preserved hippocampal novelty responses following anterior temporal‐lobe resection that impairs familiarity but spares recollection

et al. 2011

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“…The sensitivity and specificity of language activation maps depend largely on how well the activation and control tasks are designed. In addition, sensitivity may vary when event-related designs are compared to traditional block designs, with block designs yielding greater sensitivity (Narayan et al 2005) Event-related single trial designs provide a means for segregating activation trials based on response accuracy or later recall of the stimulus. This has particular relevance in identifying the integrity of functional circuits, e.g., memory encoding circuits.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Functional Magnetic Resonance Imaging of Language in Epilepsy

et al. 2007

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Functional magnetic resonance imaging (fMRI) has revolutionized our understanding of functional networks and cerebral organization in both normal and pathological brains. In the present review, we describe the use of fMRI for mapping language in epilepsy patients prior to surgical intervention including a discussion of methodological issues and task design, comparisons between fMRI and the intracarotid sodium amobarbital test, fMRI studies of language reorganization, and the use of fMRI laterality indexes to predict outcome after anterior temporal lobectomy.

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“…Previous fMRI studies have mainly reported results at a group level (Powell et al 2005;Narayan et al 2005). Group results may be satisfactory for neuroscientific questions, but in a clinical setting individual data is crucial (Jansen et al 2009).…”

Section: Introductionmentioning

confidence: 99%

fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level

Strandberg

Elfgren

Mannfolk

et al. 2010

Brain Imaging and Behavior

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We present a comprehensive and clinically applicable fMRI test-including both a verbal and a visuospatial task-for assessment of hemispheric specific memory in the medial temporal lobe (MTL). fMRI data was collected from 15 healthy right-handed volunteers. Whole-brain activation was analyzed as well as activation in two regions of interest: the MTL and the anterior speech area. Laterality indices (LI) and LI-curves were calculated using the LI toolbox of Wilke and Lidzba, 2007. The fMRI paradigms successfully visualized memory-related activity in the MTL, the verbal memory measure also provided information of language lateralization. Eleven subjects showed left lateralized verbal encoding in the MTL, visuospatial memory activation was divided equally between left and right, and 14/15 subjects had left lateralized language. Lateralization data at the group level were consistent with previous studies, but a variety of activation effects were found at the individual level indicating differences in strategy during verbal and visuospatial processing. Further studies using the presented method are needed to determine its clinical usefulness.

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Experimental design for functional MRI of scene memory encoding

Cited by 16 publications

References 27 publications

Preserved hippocampal novelty responses following anterior temporal‐lobe resection that impairs familiarity but spares recollection

Preserved hippocampal novelty responses following anterior temporal‐lobe resection that impairs familiarity but spares recollection

Functional Magnetic Resonance Imaging of Language in Epilepsy

fMRI memory assessment in healthy subjects: a new approach to view lateralization data at an individual level

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