Experimental design in supercritical fluid extraction of cocaine from coca leaves

Brachet, Anne; Christen, Philippe; Gauvrit, Jean‐Yves; Longeray, R.; Lantéri, Pierre; Veuthey, Jean‐Luc

doi:10.1016/s0165-022x(00)00062-2

Cited by 37 publications

(11 citation statements)

References 9 publications

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“…The mixture was centrifuged at 1 700 g for 5 minutes. Extracts were analysed without any further purification by GC-FID and the identification of the cocaine peak was confirmed by GC-MS, as described elsewhere [20].…”

Section: Discussionmentioning

confidence: 99%

“…CO 2 /MeOH/H 2 O, 90/9/1 v/v/v, 20 MPa and 40°C for cocaine; CO 2 /MeOH, 80/20 v/v, 20 MPa and 70°C for hyoscyamine and scopolamine) in order to assess extraction times and flow rates for the complete extraction of compounds of interest. 10 minutes with a flow rate of 2 ml/min were sufficient to extract quantitatively cocaine [20], while 20 minutes with a flow rate of 1 ml/min were sufficient to extract completely hyoscyamine and scopolamine. Therefore, extraction time was set at 15 min for cocaine and 30 min for hyoscyamine and scopolamine, in order not to take into account the time as factor.…”

Section: Supercritical Fluid Extraction (Sfe)mentioning

confidence: 99%

“…Central composite designs were applied to optimise the selected SFE factors. For hyoscyamine and scopolamine extractions, all the results are reported, whereas for cocaine, the complete development was described elsewhere [20] and some results only are reported here. Hairy root extracts were analysed by micellar electrokinetic chromatography (MEKC), as already described [21].…”

Section: Introductionmentioning

confidence: 99%

“…Hairy root extracts were analysed by micellar electrokinetic chromatography (MEKC), as already described [21]. Coca extracts were analysed by capillary GC-FID [20].…”

Section: Introductionmentioning

confidence: 99%

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Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

et al. 1999

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Abstract. Central composite designs were used in the study of supercritical fluid extraction (SFE) of three tropane alkaloids : hyoscyamine and scopolamine from Datura candida x D. aurea hairy roots and cocaine from coca leaves (Erythroxylum coca). Several SFE parameters, such as pressure, temperature, the nature and percentage of the polar modifier were examined. The tropane alkaloid extraction yield was established as response. A comparison between the predicted and the experimental extraction yields was established in order to assess the prediction quality of the model. Response surfaces were drawn from the mathematical models and enabled to determine the optimal conditions and to visualise the method robustness. The behaviour of the compounds investigated was discussed in relation with the selected SFE parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Supercritical Fluid Extraction (Sfe)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Hairy root extracts were analysed by micellar electrokinetic chromatography (MEKC), as already described [21]. Coca extracts were analysed by capillary GC-FID [20].…”

Section: Introductionmentioning

confidence: 99%

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Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

et al. 1999

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“…Supercritical fluids behave like gases although they have the density of liquids and as a result, they have a high diffusivity, low viscosity, good penetration capability and adjustable density (Goncalves et al, 2006). In comparison to soxhlet extraction, supercritical fluid extraction (SFE) offers several advantages such as shorter extraction times, lower solvent consumption (hence environmentally friendly), suitability for thermally labile compounds and reduced working temperature (Brachet et al, 2000).…”

Section: Supercritical Fluid Extraction (Sfe)mentioning

confidence: 99%

Modern Sample Preparation Techniques for Pesticide Analysis

Mmualefe¹,

Mpofu²,

Torto³

2011

Pesticides in the Modern World - Trends in Pesticides Analysis

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Current Awareness

2001

Phytochem. Anal.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of phytochemical analysis. Each bibliography is divided into 13 sections: 1 Books, Reviews & Symposia; 2 General; 3 Nucleic Acids; 4 Amino Acids, Proteins & Enzymes; 5 Carbohydrates; 6 Lipids; 7 Secondary Products; 8 Growth Regulators; 9 Industrially‐Important Products; 10 Toxins/Allergens; 11 Pigments; 12 Vitamins; 13 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Experimental design in supercritical fluid extraction of cocaine from coca leaves

Cited by 37 publications

References 9 publications

Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

Application of central composite designs in the supercritical fluid extraction of tropane alkaloids in plant extracts

Modern Sample Preparation Techniques for Pesticide Analysis

Current Awareness

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