Experimental Exposure to Methyltertiary-Butyl Ether

Nihlén, Annsofi; Wålinder, Robert; Löf, Agneta; Johanson, Gunnar

doi:10.1006/taap.1997.8342

Cited by 77 publications

(47 citation statements)

References 24 publications

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“…Exposure to a mixture of VOC (12-24 mg/m 3 ) resulted in a dose or time-dependent increase in blink frequency that was associated with eye irritation (83). However, such dependencies were not found for exposure to ethyl-, methyl tbutyl ether or propylene glycol monoethylether (84)(85)(86). Blink frequency has been found to increase from about 21 to 35 blinks/minute after 35 minutes of continuous exposure to formaldehyde, from 0.04 to 4 mg/m 3 (most clearly at 1.4 to 4 mg/m 3 ); in the same interval, eye irritation was reported to increase from 1.3 to just above 2 on a scale from 1 (not at all) to 4 (strong) (62).…”

Section: Trigeminal Stimulation By Indoor Pollutantsmentioning

confidence: 99%

Eye irritation and environmental factors in the office environment-hypotheses, causes and a physiological model

Wolkoff¹,

Skov²,

Franck³

et al. 2003

Scand J Work Environ Health

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Section: Trigeminal Stimulation By Indoor Pollutantsmentioning

confidence: 99%

Eye irritation and environmental factors in the office environment-hypotheses, causes and a physiological model

Wolkoff¹,

Skov²,

Franck³

et al. 2003

Scand J Work Environ Health

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“…Answers were given on a 100-mm visual analogue rating scale (VAS-scale) based on the Borg-scale (Nihlen et al 1998). The scale has endpoints graded from "no perceived symptoms at all" (0), to "unbearable symptoms" (100).…”

Section: Medical Investigationmentioning

confidence: 99%

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Wieslander

Fabjan

Vogrincic

et al. 2011

Tohoku J. Exp. Med.

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Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 ( p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol ( p < 0.001) and HDL-cholesterol ( p < 0.001) during the study period, with improved lung vital capacity ( p < 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.Keywords: antioxidant experiment; buckwheat; cholesterol; inflammation; lung function Tohoku J. Exp. Med., 2011, 225 (2), 123-130. © Tohoku University Medical PressThere is an increased interest in the beneficial health effects of dietary antioxidants intake, because they can help to prevent different types of diseases. Buckwheat is a good source of antioxidants, biologically high-valued amino acids (Krkoškova and Mrazova 2005;Jiang et al. 2007), dietary fiber (Bonafaccia et al. 2003), and minerals such as zinc, copper and manganese (Ikeda and Yamashita 1994). In Shanxi province, China, both common (Fagopyrum esculentum) and tartary (Fagopyrum tataricum) buckwheats are used to improve the health of patients with diabetes and cardiovascular diseases (Wieslander et al. 2000). A previous experimental buckwheat study concluded that intake of common buckwheat leaf tea could prevent further development of leg edema (Ihme et al. 1996), and a study by He et al. (1995) showed a cholesterol-lowering effect of buckwheat. However, there are very few studies on the health effects of buckwheat, especially buckwheat products in humans. Japanese studies indicate that some of the beneficial effects of buckwheat may be related to the low digestibility of buckwheat (Ikeda and Yamashita 1994). Skrabanja et al. (2001) reported beneficial effects of starch in common buckwheat with respect to insulin response. Buckwheat is also a good source of r...

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“…Most MTBE absorbed by the body is metabolized by the liver and then eliminated in urine, primarily as 2-hydroxyisobutyrate with tert-butyl alcohol and 2-methyl-1,2-propanediol as minor urinary metabolites (Amberg et al, 1999;Amberg et al, 2001). Depending upon the dose, more than one third of inhaled MTBE may be excreted in exhaled air (ATSDR, 1996;Nihlen et al, 1998).…”

Section: General Informationmentioning

confidence: 99%

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

Huber

Blount

Mage

et al. 2010

J Expo Sci Environ Epidemiol

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Experimental Exposure to Methyltertiary-Butyl Ether

Cited by 77 publications

References 24 publications

Eye irritation and environmental factors in the office environment-hypotheses, causes and a physiological model

Eye irritation and environmental factors in the office environment-hypotheses, causes and a physiological model

Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs

Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data

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