Experimental fragmentation studies with 12C therapy beams

Haettner, E.; Iwase, Hiroshi; Schardt, D.

doi:10.1093/rpd/ncl402

Cited by 94 publications

(120 citation statements)

References 6 publications

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“…The Monte Carlo calculations were performed both with and without taking into account nuclear fragmentation reactions. Experimental data by Schardt et al [16] are also shown for comparison. Our calculated position of the Bragg peak is about 5 mm (2%) deeper than predicted by simulations and observed by the experiment.…”

Section: Ion Passage Through the Mediummentioning

confidence: 96%

“…Indeed, it is estimated [17] as 5-15% of the total projectile energy loss. [16] So far our consideration neglects the fact that the projectile energy loss is a stochastic process, and |dT /dx| was calculated as the average LET. Therefore, we introduced the energy-loss straggling which essentially improves the agreement with the MCHIT results obtained taking into account the stochastics of energy-loss process.…”

Section: Ion Passage Through the Mediummentioning

confidence: 99%

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Ion-induced electron production in tissue-like media and DNA damage mechanisms

et al. 2008

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Abstract. We propose an inclusive approach for calculating characteristics of secondary electrons produced by ions/protons in tissue-like media. This approach is based on an analysis of the projectile's interaction with the medium on the microscopic level. It allows us to obtain the energy spectrum and abundance of secondary electrons as functions of the projectile kinetic energy. The physical information obtained in this analysis is related to biological processes responsible for the irrepearable DNA damage induced by the projectile. In particular, we consider double strand breaks of DNA caused by secondary electrons and free radicals, and local heating in the ion's track. The heating may enhance the biological effectiveness of electron/free radical interactions with the DNA and may even be considered as an independent mechanism of DNA damage. Numerical estimates are performed for the case of carbon-ion beams. The obtained dosedepth curves are compared with results of the MCHIT model based on the GEANT4 toolkit.PACS. 61.80.-x Physical radiation effects, radiation damage -87.53.-j Effects of ionizing radiation on biological systems -41.75.Aki Positive-ion beams -34.50.Bw Energy loss and stopping power

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Section: Ion Passage Through the Mediummentioning

confidence: 96%

Section: Ion Passage Through the Mediummentioning

confidence: 99%

Ion-induced electron production in tissue-like media and DNA damage mechanisms

et al. 2008

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“…Instead, we choose to fit the parameterization with measurements of the LET dependence on the penetration depth in liquid water. These depths have been measured at GSI [24,25]. This not only provides several curves at different initial energies, but also a direct comparison with the carbon ion data.…”

Section: B Semi-empirical Model Extensions For Liquid Watermentioning

confidence: 99%

“…[25] and MC simulations [22] (where no nuclear fragmentation is considered). The zoom in the inset shows also the experimental penetration depth.…”

Section: B Semi-empirical Model Extensions For Liquid Watermentioning

confidence: 99%

Spectra of secondary electrons generated in water by energetic ions

2010

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The energy distributions of secondary electrons produced by energetic carbon ions (in the energy range used, e.g., in hadron therapy) , incident on liquid water, are discussed. For low-energy ions, a new parameterization of the singly-differential ionization cross sections is introduced, based on tuning the position of the Bragg peak. The resulting parameterization allows a fast calculation of the energy spectra of secondary electrons at different depths along the ion's trajectory, especially near the Bragg peak. At the same time, this parameterization provides penetration depths for a broad range of initial-ion energies within the therapeutically-accepted error. For high-energy ions, the energy distribution is obtained with a use of the dielectric response function approach.Different models are compared and discussed. *

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“…Another example are the light fragments produced beyond the Bragg peak in tissues when hadron beams of carbon or neon at 200 400 MeV/u are used in radiotherapy [2]: the knowledge of the dierential cross-sections of various fragments in medical applications is mandatory to constrain treatment plan codes and to spare doses to healthy tissues.…”

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confidence: 99%

From Light to Heavy Nuclear Systems, Production and Decay of Fragments Studied with Powerful Arrays

Casini

Morelli²,

Barlini³

et al. 2015

Acta Phys. Pol. A

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Reactions between heavy-ions at various energy regimes produce many nuclear fragments which can be populated in highly excited states. The study of these fragments, detected at the end of their particle decay, is important to investigate nuclear forces and structure eects. In recent years there have been many eorts to extend these studies towards the drip-lines, i.e. to systems far from the β-stability valley, by using accelerated radioactive beams. The development of such infrastructures is accompanied by the development of more powerful detectors and associated electronics, capable to identify ions with very dierent sizes and kinetic energies. Here we give two examples which show how advanced arrays can contribute to the studies on nuclear phenomena. The examples come from the European FAZIA collaboration and from recent campaigns with the GARFIELD apparatus, the latter in operation at the INFN Legnaro Laboratory (Italy) where the SPES RIB facility is under construction.

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Experimental fragmentation studies with 12C therapy beams

Cited by 94 publications

References 6 publications

Ion-induced electron production in tissue-like media and DNA damage mechanisms

Ion-induced electron production in tissue-like media and DNA damage mechanisms

Spectra of secondary electrons generated in water by energetic ions

From Light to Heavy Nuclear Systems, Production and Decay of Fragments Studied with Powerful Arrays

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