Experimental immunology Expression levels of CD47 on red blood cells during their storage in blood bank

Gmerek, Katarzyna; Stachurska, Anna; Fabijańska-Mitek, Jadwiga

doi:10.5114/ceji.2013.35205

Cited by 2 publications

(1 citation statement)

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“…Infection is a serious complication of total hip arthroplasty. The rate of infection is 0.3-2.2%, despite attempts to prevent it [ 1 , 2 ]. The immune system plays a critical role in preventing infection, and red blood cells (RBCs) are an important part of the immune response [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical immunology Impact on red blood cell immunity patterns in postoperative phase following total hip arthroplasty

Yu¹,

Yin²,

Fu³

et al. 2014

cejoi

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ObjectiveIn this study, we aimed to measure changes in red blood cell (RBC) immunity and cytokine levels after performing total hip replacement surgery.Material and methodsTwenty patients receiving total hip arthroplasty were investigated by measuring presurgical and postoperative RBC natural tumor erythrocyte rosette rate (NTERR), RBC C3b receptor rosette rate (RC3bRR), RBC membrane CD35, CD58 and CD59 expression and cytokine levels [including tumor necrosis factor α (TNF-α), interleukin 2 (IL-2), interferon γ (IFN-γ), interleukin 10 (IL-10) and prostaglandin E2 (PGE2)]. Blood samples were collected on the day before surgery and on the first day after hip arthroplasty.ResultsPostoperative NTERR and RC3bRR were significantly lower than presurgical levels (p < 0.05). The RBC membrane CD35, CD58 and CD59 expressions were significantly decreased in the postoperative phase compared to pre-operative levels. Importantly, RBC promoting lymphocyte proliferation rates were significantly reduced after surgery. In addition, postoperative TNF-α, IL-2 and IFN-γ levels in RBC and lymphocyte culture fluid were lower than those pre-operation, whereas IL-10 and PGE2 were significantly increased compared to presurgical levels (p < 0.05).ConclusionsThe modification of RBC immune function may be involved in the occurrence and development of the infection following hip arthroplasty, and this suggests a novel strategy to prevent such infection.

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