Experimental investigation on the operating variables of a near-field electrospinning process via response surface methodology

Padmanabhan, Thirumalpathy; Kamaraj, Vivekanand; Magwood, Leroy; Starly, Binil

doi:10.1016/j.jmapro.2011.01.003

Cited by 35 publications

(17 citation statements)

References 19 publications

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“…Several studies have focused on NFES to evaluate substrate effects [15] , patterns [16] , and parameters optimization [17] . However, these achievements are only limited to 2D graphic and patterning applications.…”

Section: Introductionmentioning

confidence: 99%

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Liu¹,

Vijayavenkataraman²,

Wang³

et al. 2017

ijb

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Abstract:One of the important constituents in tissue engineering is scaffold, which provides structural support and suitable microenvironment for the cell attachment, growth and proliferation. To fabricate micro/nano structures for soft tissue repair and three-dimensional (3D) cell culture, the key is to improve fibre-based scaffold fabrication. Electrohydrodynamic (EHD) jetting is capable of producing and orientating submicron fibres for 3D scaffold fabrication. In this work, an EHD-jetting system was developed to explore the relationship between vital processing parameters and fibre characteristics. In this study, polycaprolactone (PCL) solution prepared by dissolving PCL pellets in acetic acid was used to fabricate the scaffolds. The influence of voltage, motorized stage speed, solution feed rate, and solution concentration on fibre characteristics and scaffold pattern were studied. Morphology of the EHD-jetted PCL fibres and scaffolds were analysed using optical microscope images and scanning electron microscope (SEM) images. Multi-layer scaffolds with the varied coiled pattern were fabricated and analysed. Cell attachment and proliferation have to be investigated in the future by further cell culture studies on these multi-layer coiled scaffolds.

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Section: Introductionmentioning

confidence: 99%

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Liu¹,

Vijayavenkataraman²,

Wang³

et al. 2017

ijb

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“…Processing parameters investigated were the solution concentration, applied voltage, take‐up rate, and distance of the center between the needles and the take‐up unit. RSM has been applied recently to analyze the effect of electrospinning parameters on the final properties of nanofibers . Using this method, an empirical relationship between independent variables and one or more response variables is obtained.…”

Section: Introductionmentioning

confidence: 99%

“…Using this method, an empirical relationship between independent variables and one or more response variables is obtained. Moreover, the use of this model allows a straightforward and systematic representation of the processing parameters inflencing fiber and yarn formation, and can be used to predict the results of the experiments applying different combinations …”

Section: Introductionmentioning

confidence: 99%

The influence of process parameters on the properties of electrospun PLLA yarns studied by the response surface methodology

Maleki

Gharehaghaji

Criscenti

et al. 2014

J of Applied Polymer Sci

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Poly (l‐lactide) (PLLA) fibrous yarns were prepared by electrospinning of polymer solutions in 2,2,2‐trifluoroethanol. Applying spinning from two oppositely charged needles the spontaneous formed triangle of fibers at a grounded substrate could be assembled into fibrous yarns using a device consisting of a take‐up roller and twister. The effect of processing parameters on the morphology, diameter and mechanical properties of PLLA yarns was investigated by the response surface methodology (RSM). This method allowed evaluating a quantitative relationship between polymer concentration, voltage, take‐up rate and distance between the needles' center and the take‐up unit on the properties of the electrospun fibers and yarns. It was found that at increasing concentrations up to 9 wt % uniform fibers were obtained with increasing mean diameters. Conversely, the fiber diameter decreased slightly when the applied voltage was increased. The take‐up rate had a significant influence on the yarn diameter, which increased as the take‐up rate decreased. The tensile strength and modulus of the yarns were correlated with these variables and it was found that the polymer concentration had the largest influence on the mechanical properties of the yarns. By applying the RSM, it was possible to obtain a relationship between processing parameters which are important in the fabrication of electrospun yarns. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41388.

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“…In investigating electrospun fibre properties with respect to the multivariate nature of electrospinning, the RSM approach has been applied in numerous electrospinning studies of various materials [ 26 , 32 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. These investigations demonstrated that this technique could develop a predictive model along with confirmation of validity.…”

Section: Introductionmentioning

confidence: 99%

“…Mostly, fibre diameter was the response under investigation. Although these studies were conducted using different materials and experimental conditions, they appeared to be in good agreement, in which the most influential factors for fibre diameter are material content or concentration [ 26 , 32 , 34 , 36 , 37 , 38 , 39 , 40 ] and voltage [ 26 , 32 , 34 , 35 , 36 , 37 , 40 ]. Only a few studies examined the effect on mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology

Anindyajati¹,

Boughton²,

Ruys³

2018

Materials

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Electrospun fibres have gained broad interest in biomedical applications, including tissue engineering scaffolds, due to their potential in mimicking extracellular matrix and producing structures favourable for cell and tissue growth. The development of scaffolds often involves multivariate production parameters and multiple output characteristics to define product quality. In this study on electrospinning of polycaprolactone (PCL), response surface methodology (RSM) was applied to investigate the determining parameters and find optimal settings to achieve the desired properties of fibrous scaffold for acetabular labrum implant. The results showed that solution concentration influenced fibre diameter, while elastic modulus was determined by solution concentration, flow rate, temperature, collector rotation speed, and interaction between concentration and temperature. Relationships between these variables and outputs were modelled, followed by an optimization procedure. Using the optimized setting (solution concentration of 10% w/v, flow rate of 4.5 mL/h, temperature of 45 °C, and collector rotation speed of 1500 RPM), a target elastic modulus of 25 MPa could be achieved at a minimum possible fibre diameter (1.39 ± 0.20 µm). This work demonstrated that multivariate factors of production parameters and multiple responses can be investigated, modelled, and optimized using RSM.

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Experimental investigation on the operating variables of a near-field electrospinning process via response surface methodology

Cited by 35 publications

References 19 publications

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

Influence of electrohydrodynamic jetting parameters on the morphology of PCL scaffolds

The influence of process parameters on the properties of electrospun PLLA yarns studied by the response surface methodology

Modelling and Optimization of Polycaprolactone Ultrafine-Fibres Electrospinning Process Using Response Surface Methodology

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