Experimental Mandibular Regrowth by Distraction Osteogenesis: Long-term Results

Costantino, Peter D.; Friedman, Craig D.; Shindo, Maise L.; Houston, Glenn D.; Sisson, George A.

doi:10.1001/archotol.1993.01880170035007

Cited by 113 publications

(29 citation statements)

References 9 publications

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“…Bone elongation begins when the callus formed after the osteotomy is slowly distracted. Tensile stresses acting on the bone tissue are thought to stimulate bone re-growth in the direction of applied forces [14]. Mandibular transversal distraction osteogenesis is therefore based on the "law of tension-stress" proposed by Ilizarov [26], which states that progressive tensioning of vital tissues will create stresses that induce and maintain growth and proliferation of the tissue.…”

Section: Introductionmentioning

confidence: 99%

Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period

Boccaccio

Prendergast

Pappalettere

et al. 2007

Med Biol Eng Comput

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Mandibular symphyseal distraction osteogenesis is a common clinical procedure to modify the geometrical shape of the mandible for correcting problems of dental overcrowding and arch shrinkage. In spite of consolidated clinical use, questions remain concerning the optimal latency period and the influence of mastication loading on osteogenesis within the callus prior to the first distraction of the mandible. This work utilized a mechano-regulation model to assess bone regeneration within the callus of an osteotomized mandible. A 3D model of the mandible was reconstructed from CT scan data and meshed using poroelastic finite elements. The stimulus regulating tissue differentiation within the callus was hypothesized to be a function of the strain and fluid flow computed by the finite element model. This model was then used to analyse tissue differentiation during a fifteen day latency period, defined as the time between the day of the osteotomy and the day when the first distraction is given to the device. The following predictions are made: (i) the mastication forces generated during the latency period support osteogenesis in certain regions of the callus, and that during the latency period the percentage of progenitor cells differentiating into osteoblasts increases; (ii) reducing the mastication load by 70% during the latency period increases the number of progenitor cells differentiating into osteoblasts; (iii) the stiffness of new tissue increases at a slower rate on the side of bone callus next to the occlusion of the mandibular ramus which could cause asymmetries in the bone tissue formation with respect to the middle sagittal plane. Although the model predicts that the mastication loading generates such asymmetries, their effects on the spatial distribution of callus mechanical properties are insignificant for typical latency periods used clinically. It is also predicted that a latency period of longer than a week will increase the risk of premature bone union across the callus.

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Section: Introductionmentioning

confidence: 99%

Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period

Boccaccio

Prendergast

Pappalettere

et al. 2007

Med Biol Eng Comput

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“…More interestingly, histologic and angiographic studies have suggested inferior alveolar artery recanalization within the bone regenerate. 3 Although a large series of mandibular reconstruction by distraction osteogenesis is lacking, there are several case reports in the literature validating the clinical applicability of this principle. Costantino et al 4 in 1995 reported a case in which the authors successfully reconstructed a mandibular body segmental defect by bifocal distraction osteogenesis.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of segmental mandibular defects by distraction osteogenesis for mandibular reconstruction

2003

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“…This is a physiologic based treatment consistent with regional acceleratory phenomenon and maintaining an adequate blood supply is essential. 5 PAOO is an effective treatment approach in adults to decrease treatment time and reduce the risk of root resorption. Selected corticotomy limited to the buccal and labial aspects also significantly reduces treatment time.…”

Section: Wilckodontics/ Accelerated Osteogenic Orthodontics Technique:-mentioning

confidence: 99%

Wilckodontics: How and Why?

Vaidya¹,

Chandra²,

Jyothikiran³

et al. 2017

IJAR

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Experimental Mandibular Regrowth by Distraction Osteogenesis: Long-term Results

Cited by 113 publications

References 9 publications

Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period

Tissue differentiation and bone regeneration in an osteotomized mandible: a computational analysis of the latency period

Reconstruction of segmental mandibular defects by distraction osteogenesis for mandibular reconstruction

Wilckodontics: How and Why?

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