Experimental Models of Itch

Pereira, Ulysse; Miséry, Laurent

doi:10.1007/978-1-84882-322-8_9

Cited by 2 publications

(1 citation statement)

References 108 publications

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“…At the same time, the specific expression pattern of Pirt, which is limited to sensory neurons, indicates its potential use as a target for itch therapeutics. There are a number of mouse models to investigate various aspects of medical itch [53] – [58] that can be utilized to see if Pirt plays a role in any facet of itch in its various pathological manifestations such as inflammatory, dermatitis, etc. Our results establish a critical role for Pirt in sensing itch and generate new questions to advance knowledge of itch from both basic science and clinical perspectives.…”

Section: Discussionmentioning

confidence: 99%

Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch

et al. 2011

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Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work has begun to identify genes that contribute to detecting itch at the molecular level. Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (TRPV1) channel, is also necessary for proper itch sensation. Pirt−/− mice exhibit deficits in cellular and behavioral responses to various itch-inducing compounds, or pruritogens. Pirt contributes to both histaminergic and nonhistaminergic itch and, crucially, is involved in forms of itch that are both TRPV1-dependent and -independent. Our findings demonstrate that the function of Pirt extends beyond nociception via TRPV1 regulation to its role as a critical component in several itch signaling pathways.

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Section: Discussionmentioning

confidence: 99%