Experimental motion sickness induced in squirrel monkeys by continuous off-axis horizontal rotation

Wilpizeski, Chester R.; Lowry, Louis D.; Raheb, Magda El; Eyyunni, Uma; Contrucci, Robert B.; Goldman, Wendy S.

doi:10.1016/s0196-0709(85)80002-8

Cited by 24 publications

(3 citation statements)

References 20 publications

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“…Experimental evidence for motion sickness in nonhuman primates (e.g., Johnson et al, 1962; Wilpizeski et al, 1985; Wilpizeski, Lowry, Green, Smith & Melnick, 1987), cats and dogs (e.g., Borison & Borison, 1986; Money & Friedberg, 1964), and musk shrews (e.g., Javid & Naylor, 1999; Ueno, Matsuki & Saito, 1988) is well established when an emetic response is used as the criterion. There also is evidence for the occurrence of motion sickness in animals, such as rats, which do not possess an emetic reflex (Hatcher, 1924).…”

mentioning

confidence: 99%

Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats.

Ossenkopp¹,

Parker²,

Limebeer³

et al. 2003

Behavioral Neuroscience

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Pairing a novel taste with provocative vestibular stimulation results in conditioned taste aversions in both rats and humans. Vestibular system involvement in gustatory conditioning was examined in sham-lesioned or labyrinthectomized rats. Three conditioning trials consisted of 30 min access to asaccharin (0.1%) solution followed by 30 min of rotation (70 rpm) or sham rotation. In a taste reactivity test with saccharin, rotated sham-lesioned rats, but not labyrinthectomized rats, exhibited increased oral rejection reactions compared with control rats. When conditioned with lithium chloride, both labyrinthectomized and sham-lesioned rats displayed robust conditioned rejection reactions. The finding that normal vestibular function is necessary in obtaining rotation-induced conditioned taste aversions supports the face and construct validity of a rat model of motion sickness.

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mentioning

confidence: 99%

Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats.

Ossenkopp¹,

Parker²,

Limebeer³

et al. 2003

Behavioral Neuroscience

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“…That is why in an airplane pilot's safety instructions it is recommended to fix the head orientation in an up-right position in the situation when the pilot is experiencing vestibular illusions and/or motion sickness. Various experimental studies for flight ergonomics and sea navigation conditions have shown that motion sickness can be reduced if the head is stabilized [201,204,21].…”

Section: Non-stabilized Headmentioning

confidence: 99%

Modeling Verticality Estimation During Locomotion

Farkhatdinov

Michalska

Berthoz

et al. 2013

Romansy 19 – Robot Design, Dynamics and Control

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In this thesis, a nonlinear model of the vestibular system is proposed, with special reference to humans and other locomoting animals. The vestibular system is essential for stable locomotion since it provides idiothetic measurements of spatial orientation that are needed for postural control. The model was constructed from general considerations regarding the Newton-Euler dynamics governing the three-dimensional movements of bodies constrained to oscillate in non-inertial frames, such as the otoliths, which were modeled as spherical damped pendula. Two configurations were considered. The medial model considered only one inner ear located in the center of a head. The lateral model considered two inner ears located laterally with respect to the center of rotation of the head. The differences between these two models were analyzed and the importance of having two vestibular organs discussed. To this end, a nonlinear algebraic observability test was used to verify whether the reconstruction of the head orientation with respect to the gravitational vertical was possible from otoliths measurements only. It could be shown that in order for the head vertical orientation to be observable, the head had to be stabilized during locomotion. Moreover, it was shown that the gravitoinertial ambiguity inherent to inertial idiothetic sensing could be resolved if the head was horizontally stabilized. These results were applied to solve the head vertical orientation estimation problem in the linearized case (Luenberger observer, Kalman filter) as well as in the nonlinear case (Extended Kalman filter, Newton method based observation). These observers were designed and tested in simulations. The simulations indicated that the estimation errors were smaller and the observers converged faster when head was stabilized during locomotion, leading to a nonlinear, combined observation-control system that could be stabilized with respect to the gravitational vertical based on no other information than the prior knowledge of the Newton-Euler dynamics. The results were further tested with a specifically designed experimental setup that comprised an actuated gimbal mechanism to represent the head-neck articulation and a liquid-based inclinometer that represented the otoliths organs. The findings derived from this research would be helpful for analyzing spatial perception in humans and animals, and for improving the perceptual capabilities of robotic systems, such as humanoid robots, rough terrain vehicles, or free-moving drones.Keywords: vestibular system, head-neck system, nonlinear system, observation, estimation, verticality, spatial perception, locomotion, humanoid robot. 3 RésuméDans cette thèse, nous proposons un modèle non-linéaire du système vestibulaire, en particulier chez l'humain et autres animaux mobiles. Le système vestibulaire est essentiel pour une locomotion stable dans la mesure où il fournit des mesures idiothétiques d'orientation spatiale nécessairesà la stabilité posturale. Le développement du modèle est basé sur l...

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“…But when the otolith organ was destructed on only one side, sensitivity recovered 4.4 months after surgery, suggesting that the reorganization occurred in the central nervous system. Motion sickness can be evoked by eccentric rotation [137,139,[147][148][149]. The latencies from the stimulus onset to vomiting formed a Poisson distribution with a median value of 32.25 min (nϭ29; Bolivian), and 91% of the squirrel monkeys vomited in less than 130 min.…”

Section: Motion Sickness or Space Motion Sicknessmentioning

confidence: 99%

Squirrel Monkeys and Space Motion Sickness

Matsunami¹

2002

Jpn.J.Physiol

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Experimental motion sickness induced in squirrel monkeys by continuous off-axis horizontal rotation

Cited by 24 publications

References 20 publications

Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats.

Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats.

Modeling Verticality Estimation During Locomotion

Squirrel Monkeys and Space Motion Sickness

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