Experimental observation on antihypertensive ability of total flavonoids from Jumi in spontaneously hypertensive rats

Abstract

We observed the level of lowering blood pressure (BP) and heart rate (HR) of SHR by total falconoid from Jumi. We used SHR models, intervene them by total falconoid from Jumi, and rats were divided into SHR control groups, nifedipine control group, total falconoid high dose groups, total falconoid medium dose groups and total falconoid low dose groups. We observed the level of Bp and HR by non-invasive blood pressure. Total falconoid from Jumi significantly reduced the levels of Bp and HR when after 3 h treating by single dose test. Total falconoid from Jumi reduced the levels of them and lasted four hours and it took slower effect than nifedipine in successive administration. Effect of lowering Bp and HR among three dose groups of total falconoid wasn't significant difference. Total flavonoids from Jumi could reduce Bp and HR of SHR, and it had a better long-term effect for mild-to-moderate hypertension.