Experimental procedures for sensitive and reproducible in situ EPR tooth dosimetry

Williams, Benjamin B.; Sucheta, Artur; Dong, Ruhong; Sakata, Yasuko; Iwasaki, Akinori; Burke, Gregory C.; Grinberg, Oleg Y.; Lesniewski, Piotr; Kmiec, Maciej M.; Swartz, Harold M.

doi:10.1016/j.radmeas.2007.05.001

Cited by 23 publications

(25 citation statements)

References 22 publications

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“…The other two operated the electronics and computer interface. Operators were members of the research team and operated the in vivo EPR dosimetry system on a daily basis for the purpose of clinical studies, described elsewhere (Williams et al 2007, 2010). One additional person was in charge of greeting patients and stakeholders, as well as handling consent forms and questionnaires.…”

Section: Methodsmentioning

confidence: 99%

“…Details regarding the in vivo EPR dosimetry technique and its associated safety, reliability and accuracy have been reported elsewhere (Salikhov and Swartz 2005; Swartz et al 2005, 2006, 2007; Williams et al 2007, 2010). The methodology described here is based on a participatory-design approach that involves key stakeholders early in the development phase of the technology through the use of a simulation exercise.…”

Section: Introductionmentioning

confidence: 99%

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The View From the Trenches: Part 2–technical Considerations for Epr Screening

Nicolalde¹,

Gougelet²,

Rea³

et al. 2010

Health Physics

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There is growing awareness of the need for methodologies that can be used retrospectively to provide the biodosimetry needed to carry out screening and triage immediately after an event in which large numbers of people have potentially received clinically significant doses of ionizing radiation. The general approach to developing such methodologies has been a technology centric one, often ignoring the system integrations considerations that are key to their effective use. In this study an integrative approach for the evaluation and development of a physical biodosimetry technology was applied based on in vivo electron paramagnetic resonance (EPR) dosimetry. The EPR measurements are based on physical changes in tissues whose magnitudes are not affected by the factors that can confound biologically-based assessments. In this study the use of a pilot simulation exercise to evaluate an experimental EPR system and gather stakeholders’ feedback early on in the development process is described. The exercise involved: ten non-irradiated participants, representatives from a local fire department; Department of Homeland Security certified exercise evaluators, EPR experts, physicians; and a human factors engineer. Stakeholders were in agreement that the EPR technology in its current state of development could be deployed for the screening of mass casualties. Furthermore, stakeholders’ recommendations will be prioritized and incorporated in future developments of the EPR technique. While the results of this exercise were aimed specifically at providing feedback for the development of EPR dosimetry for screening mass casualties, the methods and lessons learned are likely to be applicable to other biodosimetric methods.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The View From the Trenches: Part 2–technical Considerations for Epr Screening

Nicolalde¹,

Gougelet²,

Rea³

et al. 2010

Health Physics

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“…Other studies included radiotherapy patients. Williams et al (2007) examined reproducibility of the technique, primarily due to tooth placement within the resonator cavity. Measurements on volunteer patients who had not undergone irradiation and patients that had undergone total body irradiation treatments have produced encouraging results and development of this approach continues.…”

Section: In Vivo Dosimetrymentioning

confidence: 99%

Retrospective and emergency dosimetry in response to radiological incidents and nuclear mass-casualty events: A review

Bailiff

Sholom

McKeever

2016

Radiation Measurements

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Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. HIGHLIGHTSReview of the use of luminescence and electron paramagnetic resonance in retrospective and emergency dosimetry.Optically stimulated luminescence (OSL), thermoluminescence (TL) and Electron Paramagnetic Resonance (EPR) results on biological and physical materials.Descriptions of use in emergency and retrospective dosimetry, following large-scale radiological events.http://www.sciencedirect.com/science/article/pii/S1350448716302359 ABSTRACTThis paper reviews recent research on the application of the physical dosimetry techniques of electron paramagnetic resonance (EPR) and luminescence (optically stimulated luminescence, OSL, and thermoluminescence, TL) to determine radiation dose following catastrophic, large-scale radiological events. Such data are used in dose reconstruction to obtain estimates of dose due to the exposure to external sources of radiation, primarily gamma radiation, by individual members of the public and by populations. The EPR and luminescence techniques have been applied to a wide range of radiological studies, including nuclear bomb detonation (e.g., Hiroshima and Nagasaki) nuclear power plant accidents (e.g., Chernobyl), radioactive pollution (e.g., Mayak plutonium facility), and in the future could include terrorist events involving the dispersal of radioactive materials. In this review we examine the application of these techniques in 'emergency' and 'retrospective' modes of operation that are conducted on two distinct timescales. For emergency dosimetry immediate action to evaluate dose to individuals following radiation exposure is required to assess deterministic biological effects and to enable rapid medical triage. Retrospective dosimetry, on the other hand, contributes to the reconstruction of doses to populations and individuals following external exposure, and contributes to the long-term study of stochastic processes and the consequential epidemiological effects. Although internal exposure, via ingestion of radionuclides for example, can be a potentially significant contributor to dose, this review is confined to those dose components arising from exposure to external radiation, which in most studies is gamma radiation.The nascent emergency dosimetry measurement techniques aim to perform direct dose evaluations for individuals who, as members of the public, are most unlikely to be carrying a dosimeter issued for radiation monitoring purposes in the event of a radiation incident. Hence attention has focused on b...

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“…The materials used in constructing and testing the tooth models include: Details of the EPR in vivo tooth dosimetry device have been reported elsewhere (1)(2)(3)(8)(9)(10)(11)(12)(13)(14) . The tooth being queried by the device reported here was one or both of central incisors in the maxillary jaw.…”

Section: Materials and Instrumentsmentioning

confidence: 99%

Evolution and Optimization of Tooth Models for TestingIn VivoEPR Tooth Dosimetry

Kobayashi¹,

Dong²,

Nicolalde³

et al. 2016

Radiat Prot Dosimetry

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Testing and verification are an integral part of any cycle to design, manufacture and improve a novel device intended for use in humans. In the case of testing Dartmouth's electron paramagnetic resonance (EPR) in vivo tooth dosimetry device, in vitro studies are needed throughout its development to test its performance, i.e. to verify its current capability for assessing dose in individuals potentially exposed to ionizing radiation. Since the EPR device uses the enamel of human teeth to assess dose, models that include human teeth have been an integral mechanism to carry out in vitro studies during development and testing its ability to meet performance standards for its ultimate intended in vivo use. As the instrument improves over time, new demands for in vitro studies change as well. This paper describes the tooth models used to perform in vitro studies and their evolution to meet the changing demands for testing in vivo EPR tooth dosimetry.

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Experimental procedures for sensitive and reproducible in situ EPR tooth dosimetry

Cited by 23 publications

References 22 publications

The View From the Trenches: Part 2–technical Considerations for Epr Screening

The View From the Trenches: Part 2–technical Considerations for Epr Screening

Retrospective and emergency dosimetry in response to radiological incidents and nuclear mass-casualty events: A review

Evolution and Optimization of Tooth Models for TestingIn VivoEPR Tooth Dosimetry

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